Detailed information NTG1127541

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: FGL12_RS10895
• Genome accession: NZ_LR594041
• Coordinates: 2221690..2222883 (+)
• Length: 397 a.a.
• NCBI ID: WP_012131081.1
• Uniprot ID: A0AB34SBT8
• Organism: Streptococcus gordonii strain NCTC9124
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2216690..2227883

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL12_RS10855 (NCTC9124_02190)	ychF	2217001..2218116 (-)	1116	WP_012131077.1	redox-regulated ATPase YchF	-
FGL12_RS10870 (NCTC9124_02193)	comE/comE2	2218438..2219205 (-)	768	WP_008808031.1	competence system response regulator transcription factor ComE	Regulator
FGL12_RS10875 (NCTC9124_02194)	comD/comD1	2219202..2220563 (-)	1362	WP_012131078.1	competence system sensor histidine kinase ComD	Regulator
FGL12_RS10880 (NCTC9124_02195)	comC/comC1	2220579..2220731 (-)	153	WP_012131079.1	bacteriocin	Regulator
FGL12_RS10890 (NCTC9124_02197)	rlmH	2221017..2221496 (-)	480	WP_012131080.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
FGL12_RS10895 (NCTC9124_02198)	htrA	2221690..2222883 (+)	1194	WP_012131081.1	S1C family serine protease	Regulator
FGL12_RS10900 (NCTC9124_02199)	spo0J	2222949..2223713 (+)	765	WP_012131082.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 397 a.a.
• Molecular weight: 42183.77 Da
• Isoelectric Point: 4.9802

>NTDB_id=1127541 FGL12_RS10895 WP_012131081.1 2221690..2222883(+) (htrA) [Streptococcus gordonii strain NCTC9124]
MKNSSNFFKKTLQVFIVLLVGFIGGVAGTWGFSYFSTPHSATNNNQKTATTVTTSYKNSNSTTEAVDKVKDAVVSVITYS
ESNSDAIFDNNNSGNENDQVASEGSGVIYRKDKDYAYLVTNTHVINGAKKVDIRLADGNKVPGEIVGTDTYSDISVVRIP
ADKVKNVAEFGDSSKLTVGETAIAIGSPLGSDYANTVTQGIVSSLSRNVSSRSEDGQTIATQAIQTDAAINPGNSGGPLV
NIQGQVIGITSSKIANTNNGSTSVEGMGFAIPSNDVVNIIEQLEKNGKVIRPALGIQMVNLSSLSSSSSDRLKLPDNVKN
GVVVRSTQTGMPADGKLEKYDVITKIDDTEISSASDIQSALYKHSINEEIKVTYYRDGKEQTTTIKLTKSTDDLSSE

Nucleotide

• Length: 1194 bp

>NTDB_id=1127541 FGL12_RS10895 WP_012131081.1 2221690..2222883(+) (htrA) [Streptococcus gordonii strain NCTC9124]
ATGAAAAACTCTTCAAATTTCTTTAAAAAAACATTGCAAGTTTTCATTGTTTTGTTAGTTGGTTTTATAGGTGGTGTTGC
TGGAACATGGGGATTTTCTTATTTTTCAACACCTCATTCAGCCACAAATAATAATCAGAAAACAGCGACTACAGTAACAA
CATCCTATAAAAATAGTAATTCTACAACAGAGGCTGTTGATAAAGTAAAAGATGCGGTTGTCTCTGTCATTACATATTCT
GAATCTAATTCAGATGCTATTTTCGACAACAATAATTCAGGAAATGAAAATGATCAGGTAGCTAGCGAAGGATCTGGTGT
TATCTATAGAAAAGATAAGGATTATGCTTACTTAGTTACCAATACACACGTTATCAATGGAGCAAAAAAAGTTGATATCC
GTCTTGCTGATGGGAATAAGGTTCCTGGTGAAATAGTCGGGACTGATACATATTCTGATATTTCTGTAGTCAGAATTCCT
GCCGATAAAGTTAAAAATGTGGCAGAATTTGGGGATTCTAGTAAATTAACTGTTGGGGAAACTGCCATTGCAATCGGAAG
TCCTCTTGGATCTGATTATGCTAATACAGTGACTCAGGGAATTGTTTCTAGTCTAAGCCGTAATGTTTCTTCACGATCAG
AAGATGGTCAGACAATTGCTACTCAAGCTATTCAAACTGATGCAGCAATTAATCCAGGTAACTCTGGTGGTCCTCTTGTA
AACATTCAAGGTCAAGTTATTGGTATTACCTCTAGTAAAATTGCTAACACCAATAATGGTAGTACTTCTGTTGAGGGAAT
GGGATTTGCAATCCCATCCAATGATGTTGTAAATATCATTGAACAATTAGAAAAGAATGGTAAAGTCATTCGACCAGCAT
TAGGAATTCAAATGGTCAACTTAAGTAGTTTGTCTTCTTCAAGCTCTGATCGATTAAAACTTCCAGACAATGTTAAAAAT
GGTGTCGTTGTTCGTTCAACACAAACTGGAATGCCTGCTGATGGTAAGTTAGAAAAATATGATGTGATTACAAAAATTGA
TGATACAGAAATATCATCTGCTAGCGATATTCAATCAGCTCTTTATAAACATTCAATTAATGAAGAAATTAAAGTTACTT
ATTATCGTGATGGAAAAGAGCAAACAACAACTATTAAACTAACTAAATCAACTGATGATTTAAGCTCTGAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (292-387)

• Peptidase family M50 (Peptidase_M50) (236-391)

• Trypsin-like peptidase domain (Trypsin_2) (104-249)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	100	100	1
htrA	Streptococcus mitis NCTC 12261	66.332	100	0.665
htrA	Streptococcus pneumoniae Rx1	66.414	99.748	0.662
htrA	Streptococcus pneumoniae D39	66.414	99.748	0.662
htrA	Streptococcus pneumoniae R6	66.414	99.748	0.662
htrA	Streptococcus pneumoniae TIGR4	66.414	99.748	0.662
htrA	Streptococcus mutans UA159	56.14	100	0.564