Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   FGL12_RS10875 Genome accession   NZ_LR594041
Coordinates   2219202..2220563 (-) Length   453 a.a.
NCBI ID   WP_012131078.1    Uniprot ID   P95767
Organism   Streptococcus gordonii strain NCTC9124     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2214202..2225563
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGL12_RS10850 (NCTC9124_02189) pth 2216358..2216927 (-) 570 WP_012131076.1 aminoacyl-tRNA hydrolase -
  FGL12_RS10855 (NCTC9124_02190) ychF 2217001..2218116 (-) 1116 WP_012131077.1 redox-regulated ATPase YchF -
  FGL12_RS10870 (NCTC9124_02193) comE/comE2 2218438..2219205 (-) 768 WP_008808031.1 competence system response regulator transcription factor ComE Regulator
  FGL12_RS10875 (NCTC9124_02194) comD/comD1 2219202..2220563 (-) 1362 WP_012131078.1 competence system sensor histidine kinase ComD Regulator
  FGL12_RS10880 (NCTC9124_02195) comC/comC1 2220579..2220731 (-) 153 WP_012131079.1 bacteriocin Regulator
  FGL12_RS10890 (NCTC9124_02197) rlmH 2221017..2221496 (-) 480 WP_012131080.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  FGL12_RS10895 (NCTC9124_02198) htrA 2221690..2222883 (+) 1194 WP_012131081.1 S1C family serine protease Regulator
  FGL12_RS10900 (NCTC9124_02199) spo0J 2222949..2223713 (+) 765 WP_012131082.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 453 a.a.        Molecular weight: 53636.59 Da        Isoelectric Point: 6.4089

>NTDB_id=1127539 FGL12_RS10875 WP_012131078.1 2219202..2220563(-) (comD/comD1) [Streptococcus gordonii strain NCTC9124]
MIFTIILSLFPVIIQVFSYDFFYNKINRKKKINIKLIILFWGLIMVISFLYSLFLLLPDYWKIFRDIFHYLFLLIQPLIF
YKYFLIKRKEYENYLNLFLSFVIYLSVETSETFLSVIISSITGDSFVKQHYDIFYIIINLLSLFIILKVVDFFDFYFEYY
KEPIYKNDLYNVNKSYIVIHILLNISHWFSENAHLNSFASMIATIGFIMFLSTLFYLKSAREQYEKAKEIQQKKEEQRQL
QLYTDEIVGLYNEIRGFRHDYAGMLTSLQTGINSGDMKEVERIFHNVLSQANISLRSDDYTFFELNNVQDTALRSVLIQT
IFKARECGVEIVFEMKDVIETLPMKLLDLVRVASVLLNNAVEGAAESPSKTMNVSLVKLDKEIVFVIQNSRQSRYINLEE
IYEVGFSTKGENRGLGLNNVKEIIDKYDEVILETDIETNYFIQVVRFKRKEKI

Nucleotide


Download         Length: 1362 bp        

>NTDB_id=1127539 FGL12_RS10875 WP_012131078.1 2219202..2220563(-) (comD/comD1) [Streptococcus gordonii strain NCTC9124]
ATGATATTTACAATAATACTGTCTTTATTTCCAGTTATAATACAAGTTTTTTCCTATGATTTTTTTTACAATAAAATTAA
TAGAAAAAAGAAAATTAATATTAAACTCATTATTCTATTTTGGGGTTTAATAATGGTAATATCATTTCTTTATTCTCTAT
TCTTATTATTACCAGATTATTGGAAAATTTTTCGAGATATTTTTCATTATTTATTTTTACTTATTCAGCCTCTTATTTTC
TACAAATATTTTCTTATTAAAAGAAAAGAGTATGAAAATTACTTGAATTTGTTTTTATCGTTTGTTATCTATTTATCTGT
GGAGACTTCTGAAACTTTTTTATCTGTCATTATTTCTTCAATAACAGGAGATTCTTTTGTAAAACAACATTATGATATTT
TTTACATTATAATTAATCTTTTATCTTTGTTTATTATTTTAAAGGTTGTTGATTTTTTTGACTTTTATTTTGAGTACTAT
AAAGAACCAATTTATAAAAATGATCTATATAATGTCAATAAGTCATATATAGTAATCCATATCCTATTAAATATTTCTCA
TTGGTTCAGCGAAAATGCACATCTTAATAGCTTTGCTAGTATGATTGCAACTATAGGATTTATTATGTTTTTGTCGACTT
TATTTTATCTGAAGTCTGCTCGTGAACAATATGAAAAAGCTAAAGAAATTCAGCAAAAAAAGGAAGAACAAAGACAACTA
CAACTTTATACAGATGAAATTGTAGGTCTTTATAACGAAATTCGAGGTTTTCGTCACGATTATGCTGGTATGTTAACAAG
TTTGCAAACCGGAATTAACTCAGGTGATATGAAAGAAGTAGAGCGAATCTTTCATAATGTTTTAAGTCAAGCTAATATTT
CCCTTCGATCAGATGACTATACTTTTTTTGAGTTAAATAATGTTCAAGACACTGCCTTGAGAAGTGTGTTAATTCAAACT
ATATTTAAGGCTCGAGAGTGTGGAGTAGAGATCGTATTTGAAATGAAGGATGTTATTGAGACATTACCTATGAAACTTTT
AGATTTAGTTCGAGTAGCTAGTGTATTGCTCAATAATGCAGTTGAAGGGGCAGCTGAAAGTCCCTCAAAAACAATGAACG
TGTCTTTAGTAAAGCTAGATAAAGAAATTGTTTTTGTAATTCAGAATTCTCGTCAAAGCCGTTACATTAATTTAGAAGAA
ATTTATGAAGTAGGCTTCTCAACAAAAGGAGAAAATCGAGGATTAGGTTTAAATAATGTCAAAGAAATTATTGACAAATA
TGATGAAGTTATTCTGGAAACAGATATAGAAACAAATTATTTTATACAAGTTGTAAGATTTAAAAGAAAGGAAAAAATAT
GA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(344-445)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P95767

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

100

100

1
  comD/comD2 Streptococcus gordonii strain NCTC7865

89.845

100

0.898
  comD/comD2 Streptococcus pneumoniae TIGR4

47.17

93.598

0.442
  comD/comD1 Streptococcus pneumoniae D39

47.17

93.598

0.442
  comD/comD1 Streptococcus pneumoniae R6

47.17

93.598

0.442
  comD/comD1 Streptococcus pneumoniae Rx1

47.17

93.598

0.442
  comD Streptococcus mitis SK321

46.682

93.157

0.435
  comD Streptococcus mitis NCTC 12261

45.647

93.819

0.428

Multiple sequence alignment