Detailed information NTG1121876

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EL140_RS09530
• Genome accession: NZ_LR134336
• Coordinates: 1926159..1926911 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866079.1
• Uniprot ID: A0A081R422
• Organism: Streptococcus oralis ATCC 35037 strain NCTC 11427
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1921159..1931911

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL140_RS09510 (NCTC11427_01881)	-	1922597..1925251 (-)	2655	WP_000472066.1	YhgE/Pip domain-containing protein	-
EL140_RS09515 (NCTC11427_01882)	-	1925379..1925921 (+)	543	WP_000665080.1	TetR/AcrR family transcriptional regulator	-
EL140_RS09530 (NCTC11427_01885)	comE	1926159..1926911 (-)	753	WP_000866079.1	competence system response regulator transcription factor ComE	Regulator
EL140_RS09535 (NCTC11427_01886)	comD	1926908..1928227 (-)	1320	WP_000054555.1	competence system sensor histidine kinase ComD	Regulator
EL140_RS09540 (NCTC11427_01887)	comC/comC1	1928248..1928373 (-)	126	WP_002874960.1	competence-stimulating peptide ComC	Regulator
EL140_RS09550 (NCTC11427_01889)	rlmH	1928655..1929134 (-)	480	WP_000694221.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EL140_RS09555 (NCTC11427_01890)	htrA	1929320..1930516 (+)	1197	WP_000681805.1	S1C family serine protease	Regulator
EL140_RS09560 (NCTC11427_01891)	spo0J	1930574..1931332 (+)	759	WP_000410357.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29884.23 Da
• Isoelectric Point: 6.9755

>NTDB_id=1121876 EL140_RS09530 WP_000866079.1 1926159..1926911(-) (comE) [Streptococcus oralis ATCC 35037 strain NCTC 11427]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYCSHKSFLVNVGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=1121876 EL140_RS09530 WP_000866079.1 1926159..1926911(-) (comE) [Streptococcus oralis ATCC 35037 strain NCTC 11427]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTAAATGAAATCTCGGAAGAATC
GAATATTCCTATTTCATATAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTCCTAGATATCGATATTCATGGAATCGAGAAAAAAGGCTTTGAAGTGGCTCAGTTTATCCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACCAGTCGATCTGAATTTGCTACCTTAACTTACAAATACCAGGTATCAGCTCTAGATTT
TGTAGACAAAGACATCAATGATGAATTGTTCAAAAAACGTATCGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAAGGAAATGATTTGAAAATTCCTTACCATGACATTTTGTAT
ATCGAAACCACAGGAGTTTCTCATAAACTTCGGATTATTGGTAAGAATTTTGCTAAAGAATTCTATGGAACTATGACAGA
TATTCAGGAAAAGGACAAACATACCCAGCGATTTTATTGCTCCCATAAATCTTTCCTTGTCAATGTGGGAAATGTGAGAG
AAATTGATCGAAAGAATTTAGAAGTTGTCTTTTATGAAGATCATCGTTGCCCGATTACCCGTTTGAAAGTTCGCAAACTA
AAAGATATTCTAGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: A0A081R422

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	95.6	100	0.956
comE	Streptococcus mitis SK321	94.8	100	0.948
comE	Streptococcus pneumoniae Rx1	94	100	0.94
comE	Streptococcus pneumoniae D39	94	100	0.94
comE	Streptococcus pneumoniae R6	94	100	0.94
comE	Streptococcus pneumoniae TIGR4	94	100	0.94
comE	Streptococcus infantis strain Atu-4	93.6	100	0.936
comE/comE2	Streptococcus gordonii strain NCTC7865	63.2	100	0.632
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.2	100	0.632
comE/blpR	Streptococcus mutans UA159	40.486	98.8	0.4