Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC1   Type   Regulator
Locus tag   EL140_RS09540 Genome accession   NZ_LR134336
Coordinates   1928248..1928373 (-) Length   41 a.a.
NCBI ID   WP_002874960.1    Uniprot ID   O33689
Organism   Streptococcus oralis ATCC 35037 strain NCTC 11427     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 1923248..1933373
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL140_RS09515 (NCTC11427_01882) - 1925379..1925921 (+) 543 WP_000665080.1 TetR/AcrR family transcriptional regulator -
  EL140_RS09530 (NCTC11427_01885) comE 1926159..1926911 (-) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  EL140_RS09535 (NCTC11427_01886) comD 1926908..1928227 (-) 1320 WP_000054555.1 competence system sensor histidine kinase ComD Regulator
  EL140_RS09540 (NCTC11427_01887) comC/comC1 1928248..1928373 (-) 126 WP_002874960.1 competence-stimulating peptide ComC Regulator
  EL140_RS09550 (NCTC11427_01889) rlmH 1928655..1929134 (-) 480 WP_000694221.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EL140_RS09555 (NCTC11427_01890) htrA 1929320..1930516 (+) 1197 WP_000681805.1 S1C family serine protease Regulator
  EL140_RS09560 (NCTC11427_01891) spo0J 1930574..1931332 (+) 759 WP_000410357.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4987.71 Da        Isoelectric Point: 9.8680

>NTDB_id=1121878 EL140_RS09540 WP_002874960.1 1928248..1928373(-) (comC/comC1) [Streptococcus oralis ATCC 35037 strain NCTC 11427]
MKNTEKLEQFKEVTEAELQEIRGGDKRLPYFFKHLFSNRTK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=1121878 EL140_RS09540 WP_002874960.1 1928248..1928373(-) (comC/comC1) [Streptococcus oralis ATCC 35037 strain NCTC 11427]
ATGAAAAATACAGAAAAGTTGGAACAATTTAAAGAAGTAACAGAGGCAGAATTGCAGGAGATTCGAGGTGGAGATAAAAG
ACTACCTTACTTTTTTAAACATCTTTTTTCAAATAGGACAAAGTAG

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-31)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB O33689

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC1 Streptococcus pneumoniae R6

51.22

100

0.512
  comC/comC1 Streptococcus pneumoniae G54

51.22

100

0.512
  comC/comC1 Streptococcus pneumoniae D39

51.22

100

0.512
  comC/comC1 Streptococcus pneumoniae Rx1

51.22

100

0.512
  comC Streptococcus mitis SK321

65.517

70.732

0.463
  comC/comC2 Streptococcus pneumoniae A66

55.172

70.732

0.39
  comC/comC2 Streptococcus pneumoniae TIGR4

55.172

70.732

0.39
  comC/blpC Streptococcus mutans UA159

44.118

82.927

0.366

Multiple sequence alignment