Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD   Type   Regulator
Locus tag   EL140_RS09535 Genome accession   NZ_LR134336
Coordinates   1926908..1928227 (-) Length   439 a.a.
NCBI ID   WP_000054555.1    Uniprot ID   A0A1X1H723
Organism   Streptococcus oralis ATCC 35037 strain NCTC 11427     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1921908..1933227
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL140_RS09510 (NCTC11427_01881) - 1922597..1925251 (-) 2655 WP_000472066.1 YhgE/Pip domain-containing protein -
  EL140_RS09515 (NCTC11427_01882) - 1925379..1925921 (+) 543 WP_000665080.1 TetR/AcrR family transcriptional regulator -
  EL140_RS09530 (NCTC11427_01885) comE 1926159..1926911 (-) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  EL140_RS09535 (NCTC11427_01886) comD 1926908..1928227 (-) 1320 WP_000054555.1 competence system sensor histidine kinase ComD Regulator
  EL140_RS09540 (NCTC11427_01887) comC/comC1 1928248..1928373 (-) 126 WP_002874960.1 competence-stimulating peptide ComC Regulator
  EL140_RS09550 (NCTC11427_01889) rlmH 1928655..1929134 (-) 480 WP_000694221.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EL140_RS09555 (NCTC11427_01890) htrA 1929320..1930516 (+) 1197 WP_000681805.1 S1C family serine protease Regulator
  EL140_RS09560 (NCTC11427_01891) spo0J 1930574..1931332 (+) 759 WP_000410357.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 439 a.a.        Molecular weight: 50976.92 Da        Isoelectric Point: 6.5044

>NTDB_id=1121877 EL140_RS09535 WP_000054555.1 1926908..1928227(-) (comD) [Streptococcus oralis ATCC 35037 strain NCTC 11427]
MSLLGFGIVILHIFILTISYELICKVTKKERYLFIACIFVYQSVAEFFFDFISLAGLGIEKFIFPFILYTSIVVLKKYDK
HKGMFISLLLSLLYHSTHTFLSVTLSSITGDAFVIEHEVMFYLGVLLLTYFIIKKIITYFHLELTYFDKDYLYPFLKKVI
VAFFGLHILLFISDIVSTTHHLNSFGSILSTIVFICLLLIFFAMNSHKVQIEKEIALKQKKFEQKHLQTYTDEIVELYNE
IRGFRHDYAGMLVSMQMAIDSGDLQEINRVYNEVLVKANQKLRSEKYTYFDLNNIEDSALRSLIAQSIVYARKNDVEFTL
EVKDIITRLSIDLLDLVRIMSILLNNAVEGAADSYLKQMEVAVIKMDFETVIVIQNSCKITMTPSEDLFALGFSTKGRNR
GLGLNNVKEILDKYDNIILETEMEDNTFRQIIRFKREFE

Nucleotide


Download         Length: 1320 bp        

>NTDB_id=1121877 EL140_RS09535 WP_000054555.1 1926908..1928227(-) (comD) [Streptococcus oralis ATCC 35037 strain NCTC 11427]
ATGAGTTTATTAGGATTTGGAATAGTTATTCTTCATATTTTTATTTTAACAATAAGCTATGAATTAATTTGTAAAGTAAC
TAAAAAAGAAAGATATTTATTTATAGCTTGTATATTTGTATATCAGTCTGTAGCTGAATTTTTCTTTGACTTTATTTCAT
TAGCTGGGTTAGGGATTGAAAAGTTTATATTTCCTTTTATTCTATATACTTCTATAGTAGTTTTAAAGAAGTATGATAAG
CATAAAGGAATGTTTATCAGTTTACTATTGTCTTTATTATATCATAGTACACATACTTTTTTATCAGTAACCCTATCCTC
TATAACAGGTGATGCTTTTGTGATAGAACATGAAGTGATGTTTTATTTAGGAGTACTATTACTAACATATTTTATTATTA
AAAAAATTATTACTTATTTCCATTTAGAACTTACCTATTTTGATAAAGATTATCTGTATCCTTTTTTAAAAAAAGTAATA
GTTGCTTTCTTTGGTTTACATATCTTATTGTTTATTTCAGATATAGTAAGTACAACTCATCATTTAAATAGTTTCGGAAG
TATTTTATCAACCATTGTTTTTATTTGCTTGTTATTGATTTTCTTTGCAATGAATTCTCACAAGGTTCAAATTGAAAAAG
AGATTGCTCTAAAACAAAAGAAATTTGAACAAAAACATTTACAGACTTATACTGATGAAATTGTGGAGTTATATAATGAA
ATTCGCGGTTTTCGTCATGACTATGCAGGGATGCTTGTTAGCATGCAAATGGCGATTGACAGTGGAGATTTACAAGAAAT
TAACAGGGTTTACAATGAAGTCTTAGTAAAAGCAAATCAGAAATTGAGGTCAGAAAAATATACTTACTTTGATTTAAATA
ATATAGAAGATTCTGCTTTACGAAGTTTAATTGCTCAATCGATTGTCTATGCACGAAAAAATGATGTAGAGTTTACATTG
GAAGTAAAGGATATCATTACTAGACTGTCAATAGATTTACTTGATCTTGTTCGTATCATGAGCATTTTATTAAACAATGC
TGTTGAAGGTGCTGCAGATAGTTATTTGAAACAAATGGAAGTTGCAGTCATTAAAATGGATTTTGAAACAGTTATAGTTA
TCCAGAATTCATGCAAAATTACTATGACGCCTTCAGAGGATCTATTTGCCTTAGGTTTCTCTACCAAGGGAAGAAATAGA
GGTCTAGGACTTAATAATGTCAAGGAGATTTTAGATAAGTATGACAACATTATTTTAGAAACAGAGATGGAAGACAACAC
ATTTAGACAAATTATTAGATTTAAGAGGGAATTCGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(333-432)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1X1H723

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD Streptococcus mitis NCTC 12261

75.737

100

0.761
  comD/comD2 Streptococcus pneumoniae TIGR4

74.603

100

0.749
  comD Streptococcus mitis SK321

74.376

100

0.747
  comD/comD1 Streptococcus pneumoniae R6

73.923

100

0.743
  comD/comD1 Streptococcus pneumoniae Rx1

73.923

100

0.743
  comD/comD1 Streptococcus pneumoniae D39

73.923

100

0.743
  comD/comD2 Streptococcus gordonii strain NCTC7865

50.798

85.649

0.435
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

50.267

85.194

0.428

Multiple sequence alignment