Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   EL140_RS09555 Genome accession   NZ_LR134336
Coordinates   1929320..1930516 (+) Length   398 a.a.
NCBI ID   WP_000681805.1    Uniprot ID   A0A7H9FDH2
Organism   Streptococcus oralis ATCC 35037 strain NCTC 11427     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1924320..1935516
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL140_RS09515 (NCTC11427_01882) - 1925379..1925921 (+) 543 WP_000665080.1 TetR/AcrR family transcriptional regulator -
  EL140_RS09530 (NCTC11427_01885) comE 1926159..1926911 (-) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  EL140_RS09535 (NCTC11427_01886) comD 1926908..1928227 (-) 1320 WP_000054555.1 competence system sensor histidine kinase ComD Regulator
  EL140_RS09540 (NCTC11427_01887) comC/comC1 1928248..1928373 (-) 126 WP_002874960.1 competence-stimulating peptide ComC Regulator
  EL140_RS09550 (NCTC11427_01889) rlmH 1928655..1929134 (-) 480 WP_000694221.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EL140_RS09555 (NCTC11427_01890) htrA 1929320..1930516 (+) 1197 WP_000681805.1 S1C family serine protease Regulator
  EL140_RS09560 (NCTC11427_01891) spo0J 1930574..1931332 (+) 759 WP_000410357.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 398 a.a.        Molecular weight: 42014.80 Da        Isoelectric Point: 6.3580

>NTDB_id=1121879 EL140_RS09555 WP_000681805.1 1929320..1930516(+) (htrA) [Streptococcus oralis ATCC 35037 strain NCTC 11427]
MKHLQKFYKKGVKVLVIILIGFLSGALGSFVTLQLYQKQGNQATNNNSGTVTQTSYKNENSTTQAVNKVKDAVVSIITYS
SSSSRQSSVFNADDTNSDSDNQQIASEGSGVIYKKDDKDAYLVTNTHVINGASKVDIRLADGTKVPGEIVGSDTFSDIAV
VKISSEKVTTVAEFGDSSQLSVGETAIAIGSPLGSEYANTVTQGIISSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSG
GPLVNIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDAQNIIKQLESDGKVTRPALGIQMVNLSNVGASDLRKLNIPSGL
TSGVVVRSVQNNMPANGHLQKYDVITKVDDKEIASSTDLQHALYNHAIGDTIKVTYYRNGKEETTSIKLDKNSSDLES

Nucleotide


Download         Length: 1197 bp        

>NTDB_id=1121879 EL140_RS09555 WP_000681805.1 1929320..1930516(+) (htrA) [Streptococcus oralis ATCC 35037 strain NCTC 11427]
ATGAAACACTTACAAAAATTTTACAAAAAAGGAGTTAAAGTTCTAGTAATCATTCTAATCGGATTTTTAAGTGGTGCCTT
AGGAAGTTTCGTAACATTACAACTTTATCAAAAACAAGGAAATCAAGCTACAAATAATAATTCTGGCACTGTCACTCAAA
CATCCTATAAGAATGAAAATTCAACCACTCAAGCAGTAAATAAAGTTAAGGATGCTGTTGTCTCAATCATTACTTATTCT
TCTTCTAGCAGTAGACAAAGTAGTGTATTTAATGCTGACGACACTAATTCTGATTCAGACAATCAACAAATCGCAAGTGA
GGGATCAGGTGTTATCTATAAAAAGGATGATAAAGATGCCTATCTTGTAACTAATACTCACGTTATCAATGGAGCTTCAA
AAGTTGATATACGCTTAGCTGATGGTACCAAGGTTCCTGGTGAAATTGTCGGATCTGATACCTTCTCTGATATTGCTGTC
GTTAAAATTTCTTCAGAAAAAGTTACAACAGTAGCAGAATTTGGGGATTCAAGTCAACTTAGTGTTGGAGAAACAGCGAT
TGCTATCGGTAGTCCTCTAGGTTCAGAATATGCTAATACAGTTACACAGGGGATTATTTCAAGTCTTAATCGGAATGTTT
CTCTAAAATCTGAAGATGGTCAAGCTATTTCAACAAAAGCCATTCAAACAGATACAGCCATTAACCCTGGTAACTCTGGT
GGTCCACTTGTAAACATTCAAGGACAAGTAATTGGTATTACATCAAGTAAAATTGCAAGTAATGGTGGGACATCTGTAGA
AGGTCTTGGTTTTGCAATTCCTTCAAACGATGCACAAAATATCATTAAACAGCTTGAAAGTGATGGTAAAGTGACTCGTC
CTGCTCTTGGAATTCAAATGGTCAATCTGTCAAATGTTGGAGCTAGTGATCTTAGAAAACTTAACATTCCAAGTGGCCTC
ACTTCAGGTGTAGTTGTTCGATCTGTTCAAAACAATATGCCAGCAAATGGACATCTTCAAAAATACGATGTCATTACCAA
AGTTGACGATAAAGAGATTGCTTCATCAACAGACCTACAACACGCTCTTTACAATCATGCTATTGGAGATACTATCAAAG
TAACCTACTACCGTAATGGTAAGGAGGAAACAACCTCAATTAAACTAGATAAGAATTCTAGTGATTTAGAGTCTTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(229-393)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)

PDZ domain (PDZ_2)

(294-389)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7H9FDH2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

83.668

100

0.837
  htrA Streptococcus pneumoniae Rx1

82.915

100

0.829
  htrA Streptococcus pneumoniae D39

82.915

100

0.829
  htrA Streptococcus pneumoniae R6

82.915

100

0.829
  htrA Streptococcus pneumoniae TIGR4

82.915

100

0.829
  htrA Streptococcus gordonii str. Challis substr. CH1

66.667

100

0.673
  htrA Streptococcus mutans UA159

54.315

98.995

0.538

Multiple sequence alignment