Detailed information NTG1120405

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: EL092_RS10715
• Genome accession: NZ_LR134291
• Coordinates: 2191183..2191950 (-)
• Length: 255 a.a.
• NCBI ID: WP_008808031.1
• Uniprot ID: P75031
• Organism: Streptococcus gordonii strain NCTC7868
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2186183..2196950

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL092_RS10695 (NCTC7868_02137)	pth	2189103..2189672 (-)	570	WP_012131076.1	aminoacyl-tRNA hydrolase	-
EL092_RS10700 (NCTC7868_02138)	ychF	2189746..2190861 (-)	1116	WP_012131077.1	redox-regulated ATPase YchF	-
EL092_RS10715 (NCTC7868_02141)	comE/comE2	2191183..2191950 (-)	768	WP_008808031.1	competence system response regulator transcription factor ComE	Regulator
EL092_RS10720 (NCTC7868_02142)	comD/comD1	2191947..2193308 (-)	1362	WP_012131078.1	competence system sensor histidine kinase ComD	Regulator
EL092_RS10725 (NCTC7868_02143)	comC/comC1	2193324..2193476 (-)	153	WP_012131079.1	bacteriocin	Regulator
EL092_RS10735 (NCTC7868_02145)	rlmH	2193762..2194241 (-)	480	WP_012131080.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EL092_RS10740 (NCTC7868_02146)	htrA	2194435..2195628 (+)	1194	WP_012131081.1	S1C family serine protease	Regulator
EL092_RS10745 (NCTC7868_02147)	spo0J	2195694..2196458 (+)	765	WP_012131082.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 255 a.a.
• Molecular weight: 30225.48 Da
• Isoelectric Point: 7.0651

>NTDB_id=1120405 EL092_RS10715 WP_008808031.1 2191183..2191950(-) (comE/comE2) [Streptococcus gordonii strain NCTC7868]
MKVLVLEDTIEHQVRIENVFEEISRELNLEIKAKVTGKIHEFKEYVESDEVNQLYFLDIDIKGEEQKGLEMAQFIRQHNP
YAIIVFVTSHSEFATLTFKYKVSALDFIDKDINDNSFKKRVKDCIVYTRNNLIENTDIVDFFEYSFRGNEIRIPFRDILY
IETTGSPYKLRVVGKNFFKEFYGTIAEIQEQDKELGYFFSPHKSYLSNISNISGYDKKTKDVLYYDGHRSPISRLRVRYL
KEILKAKSKKEENKK

Nucleotide

• Length: 768 bp

>NTDB_id=1120405 EL092_RS10715 WP_008808031.1 2191183..2191950(-) (comE/comE2) [Streptococcus gordonii strain NCTC7868]
ATGAAAGTATTAGTGCTAGAAGATACTATTGAACATCAAGTGAGAATTGAAAATGTCTTCGAAGAAATTTCTCGCGAACT
TAATCTTGAAATTAAAGCAAAAGTAACAGGAAAAATTCATGAATTTAAAGAATATGTTGAGTCAGACGAGGTAAATCAAC
TTTATTTCTTAGATATAGATATTAAAGGAGAAGAACAAAAAGGTCTAGAAATGGCGCAATTTATACGCCAACATAATCCC
TATGCTATCATTGTTTTTGTCACGAGTCATTCAGAATTTGCGACTTTAACTTTTAAGTATAAAGTATCAGCGTTAGATTT
TATAGATAAAGACATAAATGATAATTCTTTTAAGAAAAGAGTTAAAGATTGCATCGTTTATACACGAAATAATTTAATTG
AAAATACAGATATTGTTGACTTTTTTGAGTATAGTTTTAGAGGAAACGAAATTCGAATTCCTTTTAGAGATATTCTATAT
ATTGAGACGACAGGAAGTCCTTATAAATTAAGAGTTGTTGGAAAAAATTTCTTTAAGGAATTTTATGGGACAATAGCAGA
AATTCAAGAACAAGATAAAGAACTTGGATATTTTTTCTCACCACATAAGTCATACCTATCTAATATTAGCAACATTAGTG
GATACGACAAAAAGACAAAAGATGTTTTATATTATGATGGTCATCGTTCACCGATTTCTCGATTACGTGTCAGATACTTG
AAAGAAATACTGAAAGCCAAAAGTAAAAAAGAAGAAAATAAAAAATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: P75031

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus gordonii strain NCTC7865	100	100	1
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	100	100	1
comE	Streptococcus infantis strain Atu-4	64	98.039	0.627
comE	Streptococcus mitis NCTC 12261	64	98.039	0.627
comE	Streptococcus mitis SK321	63.2	98.039	0.62
comE	Streptococcus pneumoniae Rx1	62.8	98.039	0.616
comE	Streptococcus pneumoniae D39	62.8	98.039	0.616
comE	Streptococcus pneumoniae R6	62.8	98.039	0.616
comE	Streptococcus pneumoniae TIGR4	62.8	98.039	0.616
comE/blpR	Streptococcus mutans UA159	37.551	96.078	0.361