Detailed information NTG1120408

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: EL092_RS10740
• Genome accession: NZ_LR134291
• Coordinates: 2194435..2195628 (+)
• Length: 397 a.a.
• NCBI ID: WP_012131081.1
• Uniprot ID: A0AB34SBT8
• Organism: Streptococcus gordonii strain NCTC7868
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2189435..2200628

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL092_RS10700 (NCTC7868_02138)	ychF	2189746..2190861 (-)	1116	WP_012131077.1	redox-regulated ATPase YchF	-
EL092_RS10715 (NCTC7868_02141)	comE/comE2	2191183..2191950 (-)	768	WP_008808031.1	competence system response regulator transcription factor ComE	Regulator
EL092_RS10720 (NCTC7868_02142)	comD/comD1	2191947..2193308 (-)	1362	WP_012131078.1	competence system sensor histidine kinase ComD	Regulator
EL092_RS10725 (NCTC7868_02143)	comC/comC1	2193324..2193476 (-)	153	WP_012131079.1	bacteriocin	Regulator
EL092_RS10735 (NCTC7868_02145)	rlmH	2193762..2194241 (-)	480	WP_012131080.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EL092_RS10740 (NCTC7868_02146)	htrA	2194435..2195628 (+)	1194	WP_012131081.1	S1C family serine protease	Regulator
EL092_RS10745 (NCTC7868_02147)	spo0J	2195694..2196458 (+)	765	WP_012131082.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 397 a.a.
• Molecular weight: 42183.77 Da
• Isoelectric Point: 4.9802

>NTDB_id=1120408 EL092_RS10740 WP_012131081.1 2194435..2195628(+) (htrA) [Streptococcus gordonii strain NCTC7868]
MKNSSNFFKKTLQVFIVLLVGFIGGVAGTWGFSYFSTPHSATNNNQKTATTVTTSYKNSNSTTEAVDKVKDAVVSVITYS
ESNSDAIFDNNNSGNENDQVASEGSGVIYRKDKDYAYLVTNTHVINGAKKVDIRLADGNKVPGEIVGTDTYSDISVVRIP
ADKVKNVAEFGDSSKLTVGETAIAIGSPLGSDYANTVTQGIVSSLSRNVSSRSEDGQTIATQAIQTDAAINPGNSGGPLV
NIQGQVIGITSSKIANTNNGSTSVEGMGFAIPSNDVVNIIEQLEKNGKVIRPALGIQMVNLSSLSSSSSDRLKLPDNVKN
GVVVRSTQTGMPADGKLEKYDVITKIDDTEISSASDIQSALYKHSINEEIKVTYYRDGKEQTTTIKLTKSTDDLSSE

Nucleotide

• Length: 1194 bp

>NTDB_id=1120408 EL092_RS10740 WP_012131081.1 2194435..2195628(+) (htrA) [Streptococcus gordonii strain NCTC7868]
ATGAAAAACTCTTCAAATTTCTTTAAAAAAACATTGCAAGTTTTCATTGTTTTGTTAGTTGGTTTTATAGGTGGTGTTGC
TGGAACATGGGGATTTTCTTATTTTTCAACACCTCATTCAGCCACAAATAATAATCAGAAAACAGCGACTACAGTAACAA
CATCCTATAAAAATAGTAATTCTACAACAGAGGCTGTTGATAAAGTAAAAGATGCGGTTGTCTCTGTCATTACATATTCT
GAATCTAATTCAGATGCTATTTTCGACAACAATAATTCAGGAAATGAAAATGATCAGGTAGCTAGCGAAGGATCTGGTGT
TATCTATAGAAAAGATAAGGATTATGCTTACTTAGTTACCAATACACACGTTATCAATGGAGCAAAAAAAGTTGATATCC
GTCTTGCTGATGGGAATAAGGTTCCTGGTGAAATAGTCGGGACTGATACATATTCTGATATTTCTGTAGTCAGAATTCCT
GCCGATAAAGTTAAAAATGTGGCAGAATTTGGGGATTCTAGTAAATTAACTGTTGGGGAAACTGCCATTGCAATCGGAAG
TCCTCTTGGATCTGATTATGCTAATACAGTGACTCAGGGAATTGTTTCTAGTCTAAGCCGTAATGTTTCTTCACGATCAG
AAGATGGTCAGACAATTGCTACTCAAGCTATTCAAACTGATGCAGCAATTAATCCAGGTAACTCTGGTGGTCCTCTTGTA
AACATTCAAGGTCAAGTTATTGGTATTACCTCTAGTAAAATTGCTAACACCAATAATGGTAGTACTTCTGTTGAGGGAAT
GGGATTTGCAATCCCATCCAATGATGTTGTAAATATCATTGAACAATTAGAAAAGAATGGTAAAGTCATTCGACCAGCAT
TAGGAATTCAAATGGTCAACTTAAGTAGTTTGTCTTCTTCAAGCTCTGATCGATTAAAACTTCCAGACAATGTTAAAAAT
GGTGTCGTTGTTCGTTCAACACAAACTGGAATGCCTGCTGATGGTAAGTTAGAAAAATATGATGTGATTACAAAAATTGA
TGATACAGAAATATCATCTGCTAGCGATATTCAATCAGCTCTTTATAAACATTCAATTAATGAAGAAATTAAAGTTACTT
ATTATCGTGATGGAAAAGAGCAAACAACAACTATTAAACTAACTAAATCAACTGATGATTTAAGCTCTGAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (292-387)

• Peptidase family M50 (Peptidase_M50) (236-391)

• Trypsin-like peptidase domain (Trypsin_2) (104-249)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	100	100	1
htrA	Streptococcus mitis NCTC 12261	66.332	100	0.665
htrA	Streptococcus pneumoniae Rx1	66.414	99.748	0.662
htrA	Streptococcus pneumoniae D39	66.414	99.748	0.662
htrA	Streptococcus pneumoniae R6	66.414	99.748	0.662
htrA	Streptococcus pneumoniae TIGR4	66.414	99.748	0.662
htrA	Streptococcus mutans UA159	56.14	100	0.564