Detailed information NTG1120285

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EL087_RS09190
• Genome accession: NZ_LR134288
• Coordinates: 1851373..1852122 (-)
• Length: 249 a.a.
• NCBI ID: WP_003029521.1
• Uniprot ID: A0A4V0A713
• Organism: Streptococcus milleri strain NCTC11169
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1846373..1857122

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL087_RS09170 (NCTC11169_01887)	-	1847427..1850003 (+)	2577	WP_126408097.1	YfhO family protein	-
EL087_RS09175 (NCTC11169_01888)	-	1850047..1850904 (-)	858	WP_126408099.1	transposase	-
EL087_RS09190 (NCTC11169_01891)	comE	1851373..1852122 (-)	750	WP_003029521.1	competence system response regulator transcription factor ComE	Regulator
EL087_RS09195 (NCTC11169_01892)	comD/comD2	1852122..1853444 (-)	1323	WP_218969867.1	sensor histidine kinase	Regulator
EL087_RS09200 (NCTC11169_01893)	-	1853465..1853611 (-)	147	WP_003029519.1	bacteriocin	-
EL087_RS09210 (NCTC11169_01895)	rlmH	1853893..1854372 (-)	480	WP_049533214.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EL087_RS09215 (NCTC11169_01896)	htrA	1854565..1855755 (+)	1191	WP_126408101.1	S1C family serine protease	Regulator
EL087_RS09220 (NCTC11169_01897)	spo0J	1855810..1856577 (+)	768	WP_126408103.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29216.88 Da
• Isoelectric Point: 8.6042

>NTDB_id=1120285 EL087_RS09190 WP_003029521.1 1851373..1852122(-) (comE) [Streptococcus milleri strain NCTC11169]
MKVLVLEDEISHQVRMETTLAEIAKEMGITIKVKVTGKVREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLSDIAFKKHIKDSIEYTKATLIENKDMVDYFEYSFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDKETRRFFSPHKSYLVNIGNIKGYDKKMREIIFYEDHRCPITRMKIGKL
KAILEELKG

Nucleotide

• Length: 750 bp

>NTDB_id=1120285 EL087_RS09190 WP_003029521.1 1851373..1852122(-) (comE) [Streptococcus milleri strain NCTC11169]
ATGAAAGTATTAGTATTAGAAGATGAAATTTCACATCAAGTAAGAATGGAAACAACTTTGGCAGAGATTGCGAAAGAAAT
GGGAATTACGATAAAAGTTAAAGTAACTGGCAAAGTAAGAGAATTTAAAGAATATATTGAAAATGATGAGGTGAATCAAT
TATATTTTTTAGATATTGATATCAAAGGAGAGGAAACAAAAGGTTTAGAAATAGCAAAATTTATACGTCATCACAATCCG
TATGCTATTATTGTTTTTGTTACAACGAAATCAGAATTTGCTACGATGACATTTAAATATAAAGTATCTGCACTGGATTT
TGTTGATAAAAATTTGAGTGATATTGCTTTTAAAAAACATATAAAAGACAGCATTGAGTATACAAAAGCGACATTGATTG
AAAATAAAGATATGGTGGATTATTTTGAATATAGCTTTCGTGGCGGAGAGGTTAGAATGCCTTTTAATGACATTTTATAT
ATTGAAACGACAGGCTCTTCTCATAAATTAAGAATTGTCGGTAAAAACTTTTTTAAAGAATTTTATGGTACTATTGCAGA
TATTCAAGAAAAAGATAAAGAAACAAGACGTTTCTTTTCACCTCATAAATCTTATCTAGTCAATATTGGAAACATCAAAG
GTTATGACAAAAAAATGCGAGAAATAATTTTTTATGAAGATCATCGTTGTCCGATTACTCGAATGAAAATTGGAAAGTTA
AAGGCTATTTTAGAGGAATTAAAAGGATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: A0A4V0A713

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	70.612	98.394	0.695
comE/comE2	Streptococcus gordonii strain NCTC7865	70.492	97.992	0.691
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	70.492	97.992	0.691
comE	Streptococcus infantis strain Atu-4	69.796	98.394	0.687
comE	Streptococcus mitis SK321	69.796	98.394	0.687
comE	Streptococcus pneumoniae Rx1	69.388	98.394	0.683
comE	Streptococcus pneumoniae D39	69.388	98.394	0.683
comE	Streptococcus pneumoniae R6	69.388	98.394	0.683
comE	Streptococcus pneumoniae TIGR4	69.388	98.394	0.683
comE/blpR	Streptococcus mutans UA159	40.486	99.197	0.402
comE/comE2	Streptococcus equinus JB1	35.019	100	0.361