Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA/cilD   Type   Machinery gene
Locus tag   ACE2AN_RS09520 Genome accession   NZ_CP169564
Coordinates   1866407..1867348 (-) Length   313 a.a.
NCBI ID   WP_000249567.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 6_2F1     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1861407..1872348
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACE2AN_RS09480 comYH 1861893..1862846 (-) 954 WP_081528454.1 class I SAM-dependent methyltransferase Machinery gene
  ACE2AN_RS09485 - 1862907..1863501 (-) 595 Protein_1842 class I SAM-dependent methyltransferase -
  ACE2AN_RS09490 comGG/cglG 1863638..1864051 (-) 414 WP_050102600.1 competence type IV pilus minor pilin ComGG Machinery gene
  ACE2AN_RS09495 comGF/cglF 1864029..1864490 (-) 462 WP_000250544.1 competence type IV pilus minor pilin ComGF Machinery gene
  ACE2AN_RS09500 comGE/cglE 1864453..1864755 (-) 303 WP_000413380.1 competence type IV pilus minor pilin ComGE Machinery gene
  ACE2AN_RS09505 comGD/cglD 1864718..1865122 (-) 405 WP_000588020.1 competence type IV pilus minor pilin ComGD Machinery gene
  ACE2AN_RS09510 comGC/cglC 1865115..1865441 (-) 327 WP_000738632.1 comG operon protein ComGC Machinery gene
  ACE2AN_RS09515 comGB/cglB 1865443..1866459 (-) 1017 WP_078132093.1 competence type IV pilus assembly protein ComGB Machinery gene
  ACE2AN_RS09520 comGA/cglA/cilD 1866407..1867348 (-) 942 WP_000249567.1 competence type IV pilus ATPase ComGA Machinery gene
  ACE2AN_RS09525 - 1867424..1867789 (-) 366 WP_000286415.1 DUF1033 family protein -
  ACE2AN_RS09530 - 1867940..1868998 (-) 1059 WP_000649468.1 zinc-dependent alcohol dehydrogenase family protein -
  ACE2AN_RS09535 nagA 1869161..1870312 (-) 1152 WP_001134457.1 N-acetylglucosamine-6-phosphate deacetylase -
  ACE2AN_RS09540 - 1870465..1872282 (-) 1818 WP_001220922.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35573.48 Da        Isoelectric Point: 6.0083

>NTDB_id=1052219 ACE2AN_RS09520 WP_000249567.1 1866407..1867348(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain 6_2F1]
MVQEIAQEIIRSARKKGTQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYA
YDQKIASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFANRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=1052219 ACE2AN_RS09520 WP_000249567.1 1866407..1867348(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain 6_2F1]
ATGGTTCAAGAAATTGCACAAGAAATCATTCGTTCAGCTCGGAAAAAAGGGACGCAGGATATCTATTTTGTCCCTAAGTT
AGACGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGCTGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCG
TTATCAGTCACTTTAAGTTTGTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
TATGACCAGAAGATAGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGGCATGAGAGTTTGGTTATCCGTTTGTT
GCACGATGAGGAGCAGGACCTGCATTTTTGGTTTCAGGATATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCT
ATCTTTTTGCTGGTCCGGTTGGGAGTGGTAAGACGACCTTGATGCATGAATTGTCCAAGTCACTCTTTAAAGGACAGCAA
GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGACATGCTTCAGTTGCAGTTGAACGAAGCAATCGGCCTAAC
CTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCAGATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGG
CGCGTGCAGTGGTCAGAGCTAGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTTTGCAAGGAGTCTGCTACCAGAGATTAATCGG
GGGAGGAGGAATCGTTGACTTTGCAAACAGAGATTATCAAGAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGC
TTCTTAAAGATGGACATATCACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

99.361

100

0.994
  comGA/cglA/cilD Streptococcus pneumoniae D39

99.361

100

0.994
  comGA/cglA/cilD Streptococcus pneumoniae R6

99.361

100

0.994
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

99.361

100

0.994
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

96.486

100

0.965
  comYA Streptococcus gordonii str. Challis substr. CH1

77.742

99.042

0.77
  comYA Streptococcus mutans UA159

65.916

99.361

0.655
  comYA Streptococcus mutans UA140

65.916

99.361

0.655
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

62.581

99.042

0.62
  comGA Lactococcus lactis subsp. cremoris KW2

54.808

99.681

0.546
  comGA Latilactobacillus sakei subsp. sakei 23K

42.642

84.665

0.361

Multiple sequence alignment