Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   FGL22_RS02655 Genome accession   NZ_LR594048
Coordinates   498151..498900 (+) Length   249 a.a.
NCBI ID   WP_046159788.1    Uniprot ID   -
Organism   Streptococcus dysgalactiae subsp. equisimilis strain NCTC11556     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 493151..503900
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGL22_RS02620 (NCTC11556_00539) - 493351..494610 (-) 1260 Protein_457 ABC transporter transmembrane domain-containing protein -
  FGL22_RS02625 (NCTC11556_00540) - 494914..495141 (+) 228 WP_003062179.1 hypothetical protein -
  FGL22_RS02630 (NCTC11556_00541) - 495190..495507 (+) 318 WP_002994587.1 hypothetical protein -
  FGL22_RS02635 (NCTC11556_00542) - 495891..496154 (+) 264 WP_255306607.1 Blp family class II bacteriocin -
  FGL22_RS02640 (NCTC11556_00543) - 496168..496353 (+) 186 WP_003054392.1 hypothetical protein -
  FGL22_RS10860 (NCTC11556_00544) - 496607..496777 (+) 171 WP_014612080.1 hypothetical protein -
  FGL22_RS02650 - 496796..497902 (-) 1107 Protein_463 IS3 family transposase -
  FGL22_RS02655 (NCTC11556_00548) comE/blpR 498151..498900 (+) 750 WP_046159788.1 response regulator transcription factor Regulator
  FGL22_RS02660 (NCTC11556_00549) - 498901..500235 (+) 1335 WP_046159787.1 GHKL domain-containing protein -
  FGL22_RS02665 (NCTC11556_00550) - 500296..500421 (-) 126 WP_011017462.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  FGL22_RS02670 (NCTC11556_00551) - 500512..501855 (-) 1344 WP_138129334.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29211.53 Da        Isoelectric Point: 5.6520

>NTDB_id=1005965 FGL22_RS02655 WP_046159788.1 498151..498900(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC11556]
MNIFILEDDFLQQSRIEKIIYKILTDNKWEINHLGVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNRD
PYAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFTNVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide


Download         Length: 750 bp        

>NTDB_id=1005965 FGL22_RS02655 WP_046159788.1 498151..498900(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC11556]
ATGAATATTTTTATTTTGGAAGATGATTTTTTACAACAAAGCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTGGGAGATTAACCACTTGGGAGTTTATGGTAAACCTAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAGATTGCTGTGGAGATTAGAAATAGAGAT
CCGTACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTGTCTTTTCAATATCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTACTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTGATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterProScan.

LytTr DNA-binding domain (LytTR)

(150-239)

Response regulator receiver domain (Response_reg)

(3-119)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.918

97.992

0.538
  comE/comE1 Streptococcus equinus JB1

42.857

95.582

0.41
  comE/comE2 Streptococcus gordonii strain NCTC7865

40.476

100

0.41
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

40.476

100

0.41
  comE/comE2 Streptococcus equinus JB1

40.984

97.992

0.402
  comE Streptococcus mitis NCTC 12261

39.6

100

0.398
  comE Streptococcus mitis SK321

39.6

100

0.398
  comE Streptococcus pneumoniae Rx1

39.2

100

0.394
  comE Streptococcus pneumoniae D39

39.2

100

0.394
  comE Streptococcus pneumoniae R6

39.2

100

0.394
  comE Streptococcus pneumoniae TIGR4

39.2

100

0.394
  comE Streptococcus infantis strain Atu-4

39.113

99.598

0.39
  agrA Staphylococcus aureus N315

36.585

98.795

0.361