ICEberg
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ICE family: Tn5253
Tn5253 is a composite structure of two conjugative transposons, Tn5251 and Tn5252. We selected it as a reference and defined Tn5253 family. We classified ICE that has significant sequence alignment and syntenic 'core' structure with Tn5253 into the Tn5253 family, including Tn5252 and Tn5252-like ICEs.

#IDICE nameStrainReplicon
184 in_silico ICESpn11930Streptococcus pneumoniae 11930-
288 in_silico ICESpn11876Streptococcus pneumoniae 11876-
395 experimental Tn5252 (part of Tn5253)Streptococcus pneumoniae BM6001-
4165 experimental ICE6094Streptococcus pneumoniae Pn19-
5230 in_silico ICESp23FST81Streptococcus pneumoniae ATCC 700669NC_011900
6317 in_silico Tn2008Streptococcus pneumoniae CGSP14NC_010582
7362 experimental Tn1311Streptococcus pneumoniae SpnF21-
8363 experimental ICESpnA213Streptococcus pneumoniae SpnA213-
9364 Tn5253Streptococcus pneumoniae DP1322-
10365 experimental ICESpnKD6Streptococcus pneumoniae KD6-
11366 experimental ICESpnN24Streptococcus pneumoniae N24-
12367 experimental ICESpnJ93183Streptococcus pneumoniae J93/183-
13368 experimental ICESpnJ93292Streptococcus pneumoniae J93/292-
14369 experimental ICESpn2531Streptococcus pneumoniae PN02/2531-
15370 experimental Tn5252(SP1000)Streptococcus pneumoniae SP1000-
16371 Tn5252-likeStreptococcus pneumoniae-
17372 in_silico ICESpnP1031-1Streptococcus pneumoniae P1031NC_012467
18373 in_silico ICESpn6706B-1Streptococcus pneumoniae 670-6BNC_014498
19815 in_silico ICESpn22664Streptococcus pneumoniae 22664-
20816 in_silico ICESpn529IQStreptococcus pneumoniae Spn529-
21817 in_silico ICESpn6BST273Streptococcus pneumoniae PMEN22-
22818 in_silico ICESpn6BST90Streptococcus pneumoniae PMEN2-
23819 in_silico ICESpnDCC1524Streptococcus pneumoniae DCC1524-
24820 in_silico ICESpnDCC1738Streptococcus pneumoniae DCC1738-
25821 in_silico ICESpnDCC1902Streptococcus pneumoniae DCC1902-
26822 in_silico ICESpnSPN8332Streptococcus pneumoniae SPN8332-
27826 experimental ICESpy005IQStreptococcus pyogenes Spy005-
28828 in_silico ICESpy029IQStreptococcus pyogenes Spy029-
experimental Data derived from experimental literature
in_silico Putative ICEs predicted by bioinformatic methods
(1) Morici E et al. (2017). A new mosaic integrative and conjugative element from Streptococcus agalactiae carrying resistance genes for chloramphenicol (catQ) and macrolides [mef(I) and erm(TR)]. J Antimicrob Chemother. 72(1):64-67. [PudMed:27621174] experimental
(2) Del Grosso M et al. (2016). ICESpy009, a Conjugative Genetic Element Carrying mef(E) in Streptococcus pyogenes. Antimicrob Agents Chemother. 60(7):3906-12. [PudMed:27067338] in_silico
(3) Mingoia M et al. (2014). Genetic basis of the association of resistance genes mef(I) (macrolides) and catQ (chloramphenicol) in streptococci. Front Microbiol. 0.727083333. [PudMed:25610433]
(4) Mingoia M et al. (2014). Tn5253 family integrative and conjugative elements carrying mef(I) and catQ determinants in Streptococcus pneumoniae and Streptococcus pyogenes. Antimicrob Agents Chemother. 58(10):5886-93. [PudMed:25070090] experimental in_silico
(5) Croucher NJ et al. (2014). Variable recombination dynamics during the emergence, transmission and 'disarming' of a multidrug-resistant pneumococcal clone. BMC Biol. 12:49. [PudMed:24957517] experimental
(6) Croucher NJ et al. (2011). Rapid pneumococcal evolution in response to clinical interventions. Science. 331(6016):430-4. [PudMed:21273480] experimental
(7) Mingoia M et al. (2011). Heterogeneity of Tn5253-like composite elements in clinical Streptococcus pneumoniae isolates. Antimicrob Agents Chemother. 55(4):1453-9. [PudMed:21263055] experimental
(8) Ding F et al. (2009). Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant Streptococcus pneumoniae serotype 14. BMC Genomics. 0.526388889. [PudMed:19361343]
(9) Croucher NJ et al. (2009). Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniaeSpain23F ST81. J Bacteriol. 191(5):1480-9. [PudMed:19114491]
(10) Henderson-Begg SK et al. (2009). Diversity of putative Tn5253-like elements in Streptococcus pneumoniae. Int J Antimicrob Agents. 33(4):364-7. [PudMed:19097761] experimental
(11) Srinivas P et al. (2000). Genetic and transcriptional analysis of a regulatory region in streptococcal conjugative transposon Tn5252. Plasmid. 44(3):262-74. [PudMed:11078652] experimental
(12) Munoz-Najar U et al. (1999). An operon that confers UV resistance by evoking the SOS mutagenic response in streptococcal conjugative transposon Tn5252. J Bacteriol. 181(9):2782-8. [PudMed:10217768] experimental
(13) Sampath J et al. (1998). Identification of a DNA cytosine methyltransferase gene in conjugative transposon Tn5252. Plasmid. 39(1):63-76. [PudMed:9473447] experimental
(14) Srinivas P et al. (1997). Site-specific nicking in vitro at ori T by the DNA relaxase of Tn5252. Plasmid. 37(1):42-50. [PudMed:9073581] experimental
(15) Vijayakumar MN et al. (1995). Genetic organization of streptococcal conjugative transposon Tn5252. Dev Biol Stand. 85:63-9. [PudMed:8586242] experimental
(16) Vijayakumar MN et al. (1993). Nucleotide sequence analysis of the termini and chromosomal locus involved in site-specific integration of the streptococcal conjugative transposon Tn5252. J Bacteriol. 175(9):2713-9. [PudMed:8386725] experimental
(17) Kilic AO et al. (1994). Identification and nucleotide sequence analysis of a transfer-related region in the streptococcal conjugative transposon Tn5252. J Bacteriol. 176(16):5145-50. [PudMed:8051031] experimental
(18) Ayoubi P et al. (1991). Tn5253, the pneumococcal omega (cat tet) BM6001 element, is a composite structure of two conjugative transposons, Tn5251 and Tn5252. J Bacteriol. 173(5):1617-22. [PudMed:1847905] experimental
 
experimental experimental literature
in_silico in silico analysis literature

Genomics & Bioinformatics Group in MML, SJTU