Detailed information NTG0098156

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: R8586_RS11355
• Genome accession: NZ_AP026922
• Coordinates: 2165168..2165920 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PZ900700038
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2160168..2170920

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8586_RS11330	-	2161181..2162528 (-)	1348	Protein_2193	IS3 family transposase	-
R8586_RS11335	-	2162601..2164204 (-)	1604	Protein_2194	YhgE/Pip family protein	-
R8586_RS11340 (PC0038_22200)	-	2164383..2164925 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
R8586_RS11355 (PC0038_22210)	comE	2165168..2165920 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
R8586_RS11360 (PC0038_22220)	comD/comD1	2165917..2167242 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
R8586_RS11365 (PC0038_22230)	comC/comC1	2167263..2167388 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
R8586_RS11375 (PC0038_22240)	rlmH	2167670..2168149 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
R8586_RS11380 (PC0038_22250)	htrA	2168332..2169513 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
R8586_RS11385 (PC0038_22260)	spo0J	2169571..2170329 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=98156 R8586_RS11355 WP_000866065.1 2165168..2165920(-) (comE) [Streptococcus pneumoniae strain PZ900700038]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=98156 R8586_RS11355 WP_000866065.1 2165168..2165920(-) (comE) [Streptococcus pneumoniae strain PZ900700038]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408