Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   R9C51_RS09570 Genome accession   NZ_AP026921
Coordinates   1844520..1845776 (-) Length   418 a.a.
NCBI ID   WP_000642704.1    Uniprot ID   C1CTH7
Organism   Streptococcus pneumoniae strain PZ900700027     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1820913..1845776 1844520..1845776 within 0


Gene organization within MGE regions


Location: 1820913..1845776
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R9C51_RS09405 (PC0027_18500) groL 1820913..1822535 (-) 1623 WP_000031568.1 chaperonin GroEL -
  R9C51_RS09410 (PC0027_18510) groES 1822551..1822835 (-) 285 WP_000917330.1 co-chaperone GroES -
  R9C51_RS09415 (PC0027_18520) ssbB/cilA 1822991..1823386 (-) 396 WP_000282467.1 single-stranded DNA-binding protein Machinery gene
  R9C51_RS09420 (PC0027_18530) - 1823464..1824225 (-) 762 WP_057485735.1 SDR family NAD(P)-dependent oxidoreductase -
  R9C51_RS09425 (PC0027_18540) ytpR 1824258..1824884 (-) 627 WP_000578320.1 YtpR family tRNA-binding protein -
  R9C51_RS09430 (PC0027_18550) - 1824900..1825217 (-) 318 WP_000615767.1 thioredoxin family protein -
  R9C51_RS09435 (PC0027_18560) - 1825214..1825513 (-) 300 WP_001013974.1 DUF4651 domain-containing protein -
  R9C51_RS09440 - 1825711..1825773 (-) 63 WP_219300018.1 hypothetical protein -
  R9C51_RS09445 (PC0027_18570) - 1825798..1825989 (-) 192 WP_000291825.1 cell wall-binding protein -
  R9C51_RS09450 (PC0027_18580) - 1826150..1826824 (-) 675 WP_000725751.1 LiaF transmembrane domain-containing protein -
  R9C51_RS09455 (PC0027_18590) - 1826830..1827276 (-) 447 WP_000776594.1 LytTR family DNA-binding domain-containing protein -
  R9C51_RS09460 - 1827390..1827893 (-) 504 WP_000800928.1 phosphatase PAP2 family protein -
  R9C51_RS09465 (PC0027_18600) - 1827890..1828252 (-) 363 WP_000078805.1 DUF2200 domain-containing protein -
  R9C51_RS09470 (PC0027_18610) - 1828318..1829163 (-) 846 Protein_1859 ATP-binding cassette domain-containing protein -
  R9C51_RS09475 (PC0027_18620) rcrP 1829356..1830177 (-) 822 WP_000601682.1 ABC transporter permease Regulator
  R9C51_RS09480 (PC0027_18630) - 1830194..1830665 (-) 472 Protein_1861 MarR family winged helix-turn-helix transcriptional regulator -
  R9C51_RS09485 (PC0027_18640) - 1830789..1831505 (-) 717 WP_000532876.1 YebC/PmpR family DNA-binding transcriptional regulator -
  R9C51_RS09490 (PC0027_18650) ply 1832388..1833797 (-) 1410 WP_001284356.1 cholesterol-dependent cytolysin pneumolysin -
  R9C51_RS09495 (PC0027_18660) - 1833808..1834218 (-) 411 WP_000595762.1 hypothetical protein -
  R9C51_RS09500 (PC0027_18670) - 1834211..1834819 (-) 609 WP_000083614.1 hypothetical protein -
  R9C51_RS09505 (PC0027_18680) - 1834832..1835290 (-) 459 WP_000186955.1 DUF4231 domain-containing protein -
  R9C51_RS09510 (PC0027_18700) - 1835415..1835814 (+) 400 Protein_1867 transposase family protein -
  R9C51_RS09515 (PC0027_18710) - 1836579..1836839 (-) 261 WP_001209207.1 hypothetical protein -
  R9C51_RS09520 - 1836898..1837449 (-) 552 Protein_1869 hypothetical protein -
  R9C51_RS09525 (PC0027_18740) - 1837439..1837636 (-) 198 WP_000890144.1 hypothetical protein -
  R9C51_RS09530 (PC0027_18750) - 1837640..1838224 (-) 585 WP_023396456.1 hypothetical protein -
  R9C51_RS09535 (PC0027_18760) - 1838632..1839057 (-) 426 WP_050232770.1 hypothetical protein -
  R9C51_RS09540 (PC0027_18770) - 1839188..1839544 (-) 357 Protein_1873 ImmA/IrrE family metallo-endopeptidase -
  R9C51_RS09545 (PC0027_18780) - 1839590..1839796 (-) 207 WP_000366087.1 hypothetical protein -
  R9C51_RS09550 (PC0027_18790) - 1839783..1839944 (-) 162 WP_001055999.1 helix-turn-helix domain-containing protein -
  R9C51_RS09555 (PC0027_18800) lytA 1840290..1841246 (-) 957 WP_050232567.1 N-acetylmuramoyl-L-alanine amidase LytA -
  R9C51_RS09560 (PC0027_18810) - 1841622..1842992 (-) 1371 WP_001036271.1 MATE family efflux transporter -
  R9C51_RS09565 (PC0027_18820) recA 1843299..1844465 (-) 1167 WP_001085462.1 recombinase RecA Machinery gene
  R9C51_RS09570 (PC0027_18830) cinA 1844520..1845776 (-) 1257 WP_000642704.1 competence/damage-inducible protein A Machinery gene

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45089.42 Da        Isoelectric Point: 4.5211

>NTDB_id=98054 R9C51_RS09570 WP_000642704.1 1844520..1845776(-) (cinA) [Streptococcus pneumoniae strain PZ900700027]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGNKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=98054 R9C51_RS09570 WP_000642704.1 1844520..1845776(-) (cinA) [Streptococcus pneumoniae strain PZ900700027]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAACAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTGAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Competence-damaged protein (CinA)

(262-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C1CTH7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae Rx1

99.522

100

0.995
  cinA Streptococcus pneumoniae R6

99.522

100

0.995
  cinA Streptococcus pneumoniae TIGR4

99.282

100

0.993
  cinA Streptococcus pneumoniae D39

99.282

100

0.993
  cinA Streptococcus mitis SK321

93.301

100

0.933
  cinA Streptococcus mitis NCTC 12261

93.062

100

0.931
  cinA Streptococcus mutans UA159

70.813

100

0.708
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment