Detailed information NTG0966157

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: NYE32_RS02150
• Genome accession: NZ_CP150201
• Coordinates: 421669..422403 (+)
• Length: 244 a.a.
• NCBI ID: WP_037600451.1
• Uniprot ID: A0A074J3E5
• Organism: Streptococcus sp. FSL R7-0248
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 416669..427403

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NYE32_RS02135 (NYE32_02135)	-	417082..419664 (+)	2583	WP_037600459.1	SH3 domain-containing protein	-
NYE32_RS02140 (NYE32_02140)	-	419866..420618 (+)	753	WP_037600457.1	response regulator transcription factor	-
NYE32_RS02145 (NYE32_02145)	-	420754..421419 (+)	666	WP_037600454.1	DUF6287 domain-containing protein	-
NYE32_RS02150 (NYE32_02150)	comE/blpR	421669..422403 (+)	735	WP_037600451.1	response regulator transcription factor	Regulator
NYE32_RS02155 (NYE32_02155)	-	422400..423719 (+)	1320	WP_156685160.1	GHKL domain-containing protein	-
NYE32_RS02160 (NYE32_02160)	-	423817..424470 (+)	654	WP_037600446.1	DUF6287 domain-containing protein	-

Sequence

Protein

• Length: 244 a.a.
• Molecular weight: 28541.90 Da
• Isoelectric Point: 6.3900

>NTDB_id=966157 NYE32_RS02150 WP_037600451.1 421669..422403(+) (comE/blpR) [Streptococcus sp. FSL R7-0248]
MLNIYVLEDHFIQQNRIEEVIHTILKKNNIKVGDFEVFDKPNQLLESITERGSHQLFFLDIQIKDDTKKGLEVAKQIRKN
DPYASIVFFTTHSEYLPLTFQYQLVALDFIDKSLEGEDFQKRVESIILLTCKKIQSQNPEDAFRIENAKTVIQVPFHDIL
YFETSDIVHKVILYTKEEQIEFYGSLSQIEKSDPRLFKCHKSFLINPENVIKLDKSTGTVYFENGGVCYVSKLKLKKLLE
RISL

Nucleotide

• Length: 735 bp

>NTDB_id=966157 NYE32_RS02150 WP_037600451.1 421669..422403(+) (comE/blpR) [Streptococcus sp. FSL R7-0248]
ATGCTTAACATCTATGTTTTAGAAGATCATTTTATCCAACAAAATCGTATTGAAGAGGTTATTCATACGATTCTTAAGAA
AAATAATATTAAAGTGGGGGACTTTGAGGTTTTTGACAAACCCAATCAACTGTTAGAGTCTATTACCGAGCGAGGGTCTC
ATCAGCTCTTTTTCTTGGACATTCAAATTAAAGACGATACTAAAAAAGGTTTGGAAGTGGCTAAGCAGATTCGCAAGAAT
GATCCCTATGCCAGTATTGTTTTCTTCACGACTCATTCAGAGTATCTTCCCTTAACTTTTCAATACCAACTGGTAGCTCT
AGACTTTATTGATAAGTCTTTGGAGGGTGAGGACTTTCAAAAGCGTGTGGAAAGTATTATCTTATTAACCTGCAAAAAGA
TACAGAGTCAGAATCCAGAAGACGCTTTTCGGATTGAGAATGCTAAGACCGTTATTCAGGTTCCCTTTCATGATATCTTG
TACTTTGAGACCTCGGATATCGTTCATAAGGTTATCCTTTATACTAAAGAGGAGCAGATTGAGTTTTATGGCAGTCTCTC
ACAAATTGAAAAGAGTGACCCTAGACTGTTTAAATGCCACAAATCTTTCCTTATCAACCCAGAAAATGTCATCAAATTAG
ATAAAAGTACGGGGACAGTCTATTTTGAAAATGGTGGCGTTTGCTATGTTTCAAAGTTGAAACTAAAGAAATTGCTTGAG
AGAATCAGCCTATGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-242)

• Response regulator receiver domain (Response_reg) (6-123)

3D structure

• AlphaFold DB: A0A074J3E5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	50.82	100	0.508
comE/comE1	Streptococcus equinus JB1	48.536	97.951	0.475
comE/comE2	Streptococcus equinus JB1	42.149	99.18	0.418
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	38.272	99.59	0.381
comE/comE2	Streptococcus gordonii strain NCTC7865	38.272	99.59	0.381
comE	Streptococcus infantis strain Atu-4	37.344	98.77	0.369
comE	Streptococcus pneumoniae D39	36.929	98.77	0.365
comE	Streptococcus pneumoniae R6	36.929	98.77	0.365
comE	Streptococcus pneumoniae Rx1	36.929	98.77	0.365
comE	Streptococcus mitis SK321	36.929	98.77	0.365
comE	Streptococcus mitis NCTC 12261	36.929	98.77	0.365
comE	Streptococcus pneumoniae TIGR4	36.929	98.77	0.365