Detailed information
Bioinformatically predicted
Overview
| Name | comE/blpR | Type | Regulator |
| Locus tag | V6U66_RS02480 | Genome accession | NZ_CP145864 |
| Coordinates | 474731..475462 (+) | Length | 243 a.a. |
| NCBI ID | WP_070437583.1 | Uniprot ID | A0A5C1JI68 |
| Organism | Streptococcus salivarius strain KSS7 | ||
| Function | activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Genomic island | 448009..480007 | 474731..475462 | within | 0 |
Gene organization within MGE regions
Location: 448009..480007
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| V6U66_RS02330 (V6U66_02335) | tnpA | 448009..448482 (+) | 474 | WP_002891962.1 | IS200/IS605 family transposase | - |
| V6U66_RS02335 (V6U66_02340) | - | 448511..448927 (-) | 417 | WP_410534540.1 | hypothetical protein | - |
| V6U66_RS02340 (V6U66_02345) | - | 449573..450592 (+) | 1020 | WP_171021848.1 | IS30-like element IS1139 family transposase | - |
| V6U66_RS02345 (V6U66_02350) | - | 450994..451902 (+) | 909 | WP_206283467.1 | hypothetical protein | - |
| V6U66_RS02350 (V6U66_02355) | - | 451920..452282 (+) | 363 | WP_049529136.1 | hypothetical protein | - |
| V6U66_RS02355 (V6U66_02360) | - | 452423..453220 (+) | 798 | WP_410534541.1 | thioredoxin family protein | - |
| V6U66_RS02360 (V6U66_02365) | - | 453220..453852 (+) | 633 | WP_410534542.1 | hypothetical protein | - |
| V6U66_RS02365 (V6U66_02370) | - | 453846..454514 (+) | 669 | WP_410534543.1 | hypothetical protein | - |
| V6U66_RS02370 (V6U66_02375) | - | 455004..455162 (+) | 159 | WP_149561034.1 | thiazolylpeptide-type bacteriocin | - |
| V6U66_RS02375 (V6U66_02380) | - | 455213..455371 (+) | 159 | WP_149561034.1 | thiazolylpeptide-type bacteriocin | - |
| V6U66_RS02380 (V6U66_02385) | - | 455421..455579 (+) | 159 | WP_149561034.1 | thiazolylpeptide-type bacteriocin | - |
| V6U66_RS02385 (V6U66_02390) | - | 455629..455787 (+) | 159 | WP_149561034.1 | thiazolylpeptide-type bacteriocin | - |
| V6U66_RS02390 (V6U66_02395) | - | 455837..455995 (+) | 159 | WP_149561034.1 | thiazolylpeptide-type bacteriocin | - |
| V6U66_RS02395 (V6U66_02400) | - | 456045..456203 (+) | 159 | WP_149561034.1 | thiazolylpeptide-type bacteriocin | - |
| V6U66_RS02400 (V6U66_02405) | - | 456253..456411 (+) | 159 | WP_149561034.1 | thiazolylpeptide-type bacteriocin | - |
| V6U66_RS02405 (V6U66_02410) | - | 456462..456620 (+) | 159 | WP_149561034.1 | thiazolylpeptide-type bacteriocin | - |
| V6U66_RS02410 (V6U66_02415) | - | 456906..458108 (-) | 1203 | WP_284443991.1 | IS110 family transposase | - |
| V6U66_RS02415 (V6U66_02420) | - | 458413..459536 (-) | 1124 | Protein_415 | IS3 family transposase | - |
| V6U66_RS02420 (V6U66_02425) | - | 460195..460971 (+) | 777 | WP_070437622.1 | hypothetical protein | - |
| V6U66_RS02425 (V6U66_02430) | - | 460968..462698 (+) | 1731 | WP_070437619.1 | YcaO-like family protein | - |
| V6U66_RS02430 (V6U66_02435) | - | 462724..463566 (+) | 843 | WP_410534544.1 | ABC transporter ATP-binding protein | - |
| V6U66_RS02435 (V6U66_02440) | - | 463566..464285 (+) | 720 | WP_070437611.1 | ABC transporter permease | - |
| V6U66_RS02440 (V6U66_02445) | - | 464285..465379 (+) | 1095 | WP_410534545.1 | M20/M25/M40 family metallo-hydrolase | - |
| V6U66_RS02445 (V6U66_02450) | - | 465360..467891 (+) | 2532 | WP_245085454.1 | lantibiotic dehydratase | - |
| V6U66_RS02450 (V6U66_02455) | - | 467909..468985 (+) | 1077 | WP_410534546.1 | hypothetical protein | - |
| V6U66_RS02455 (V6U66_02460) | - | 468986..469513 (+) | 528 | WP_070437600.1 | hypothetical protein | - |
| V6U66_RS02460 (V6U66_02465) | - | 469491..471170 (+) | 1680 | WP_410534547.1 | YcaO-like family protein | - |
| V6U66_RS02465 (V6U66_02470) | - | 471177..472085 (+) | 909 | WP_073685810.1 | thiopeptide-type bacteriocin biosynthesis protein | - |
| V6U66_RS02470 (V6U66_02475) | - | 472086..472898 (+) | 813 | WP_070437591.1 | SagB/ThcOx family dehydrogenase | - |
| V6U66_RS02475 (V6U66_02480) | - | 472916..473662 (+) | 747 | WP_073685811.1 | hypothetical protein | - |
| V6U66_RS02480 (V6U66_02485) | comE/blpR | 474731..475462 (+) | 732 | WP_070437583.1 | response regulator transcription factor | Regulator |
| V6U66_RS02485 (V6U66_02490) | - | 475499..476812 (+) | 1314 | WP_070437580.1 | sensor histidine kinase | - |
| V6U66_RS02490 (V6U66_02495) | - | 477500..478393 (+) | 894 | WP_410534548.1 | ribonuclease D | - |
| V6U66_RS02495 (V6U66_02500) | - | 478707..479453 (+) | 747 | WP_149561043.1 | DUF6994 family protein | - |
| V6U66_RS02500 (V6U66_02505) | - | 479501..480007 (+) | 507 | WP_410534549.1 | NUDIX hydrolase | - |
Sequence
Protein
Download Length: 243 a.a. Molecular weight: 28359.46 Da Isoelectric Point: 5.6753
>NTDB_id=940566 V6U66_RS02480 WP_070437583.1 474731..475462(+) (comE/blpR) [Streptococcus salivarius strain KSS7]
MINIFVLEDEILQQSRIENTITEVLTKHSWKCKGPEIFGKPSQMLEAIVERGSHQLFFLDIEIRGEEKKGLDIARQIREQ
DPHATIVFVTTHSEFMPITFKYKVAALDFVDKALGNEQFTYRIESIIEYAMEKEGQAVSQDAFKFETSLAQVQVPFNKVL
YFETSPTVHKVILHTTDERLEFYASISEVERADERLYRCHKSFVVNPENIEKIDKEQRIVYFDGDQNCLISRSKMKGLKE
RIK
MINIFVLEDEILQQSRIENTITEVLTKHSWKCKGPEIFGKPSQMLEAIVERGSHQLFFLDIEIRGEEKKGLDIARQIREQ
DPHATIVFVTTHSEFMPITFKYKVAALDFVDKALGNEQFTYRIESIIEYAMEKEGQAVSQDAFKFETSLAQVQVPFNKVL
YFETSPTVHKVILHTTDERLEFYASISEVERADERLYRCHKSFVVNPENIEKIDKEQRIVYFDGDQNCLISRSKMKGLKE
RIK
Nucleotide
Download Length: 732 bp
>NTDB_id=940566 V6U66_RS02480 WP_070437583.1 474731..475462(+) (comE/blpR) [Streptococcus salivarius strain KSS7]
ATGATTAACATCTTTGTTCTAGAAGACGAAATTTTACAGCAATCTCGTATTGAAAATACGATAACAGAGGTTCTAACAAA
GCATTCTTGGAAATGTAAGGGACCTGAGATTTTTGGGAAACCCTCTCAAATGCTAGAAGCAATAGTTGAACGTGGTTCCC
ATCAACTATTCTTTCTAGATATTGAAATAAGGGGAGAAGAGAAAAAAGGATTAGATATTGCTAGACAAATACGTGAACAA
GATCCACATGCCACAATCGTATTTGTAACGACGCATTCAGAGTTTATGCCTATAACTTTTAAATACAAAGTAGCTGCTTT
AGACTTTGTTGATAAAGCCCTAGGAAACGAACAATTTACTTATCGGATTGAATCTATTATCGAGTATGCCATGGAAAAAG
AAGGACAGGCAGTCTCTCAAGATGCCTTTAAGTTTGAAACATCTTTGGCACAAGTTCAGGTTCCTTTTAATAAAGTATTG
TATTTTGAGACTTCCCCAACGGTTCACAAAGTAATTCTACATACGACAGATGAACGTCTTGAGTTTTATGCAAGTATATC
GGAAGTTGAAAGGGCAGATGAACGACTATATCGTTGTCATAAGTCTTTTGTTGTCAATCCAGAAAATATTGAAAAAATAG
ATAAAGAACAAAGAATTGTTTATTTTGATGGGGACCAAAATTGTTTAATCTCTCGTTCAAAAATGAAGGGCTTGAAAGAA
CGGATTAAATAG
ATGATTAACATCTTTGTTCTAGAAGACGAAATTTTACAGCAATCTCGTATTGAAAATACGATAACAGAGGTTCTAACAAA
GCATTCTTGGAAATGTAAGGGACCTGAGATTTTTGGGAAACCCTCTCAAATGCTAGAAGCAATAGTTGAACGTGGTTCCC
ATCAACTATTCTTTCTAGATATTGAAATAAGGGGAGAAGAGAAAAAAGGATTAGATATTGCTAGACAAATACGTGAACAA
GATCCACATGCCACAATCGTATTTGTAACGACGCATTCAGAGTTTATGCCTATAACTTTTAAATACAAAGTAGCTGCTTT
AGACTTTGTTGATAAAGCCCTAGGAAACGAACAATTTACTTATCGGATTGAATCTATTATCGAGTATGCCATGGAAAAAG
AAGGACAGGCAGTCTCTCAAGATGCCTTTAAGTTTGAAACATCTTTGGCACAAGTTCAGGTTCCTTTTAATAAAGTATTG
TATTTTGAGACTTCCCCAACGGTTCACAAAGTAATTCTACATACGACAGATGAACGTCTTGAGTTTTATGCAAGTATATC
GGAAGTTGAAAGGGCAGATGAACGACTATATCGTTGTCATAAGTCTTTTGTTGTCAATCCAGAAAATATTGAAAAAATAG
ATAAAGAACAAAGAATTGTTTATTTTGATGGGGACCAAAATTGTTTAATCTCTCGTTCAAAAATGAAGGGCTTGAAAGAA
CGGATTAAATAG
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comE/blpR | Streptococcus mutans UA159 |
55.51 |
100 |
0.56 |
| comE/comE1 | Streptococcus equinus JB1 |
46.218 |
97.942 |
0.453 |
| comE/comE2 | Streptococcus equinus JB1 |
40.083 |
99.588 |
0.399 |
| comE | Streptococcus mitis SK321 |
38.115 |
100 |
0.383 |
| comE | Streptococcus pneumoniae R6 |
38.115 |
100 |
0.383 |
| comE | Streptococcus pneumoniae TIGR4 |
38.115 |
100 |
0.383 |
| comE | Streptococcus mitis NCTC 12261 |
38.115 |
100 |
0.383 |
| comE | Streptococcus pneumoniae Rx1 |
38.115 |
100 |
0.383 |
| comE | Streptococcus pneumoniae D39 |
38.115 |
100 |
0.383 |
| comE | Streptococcus infantis strain Atu-4 |
37.652 |
100 |
0.383 |
| comE/comE1 | Streptococcus gordonii str. Challis substr. CH1 |
37.247 |
100 |
0.379 |
| comE/comE2 | Streptococcus gordonii strain NCTC7865 |
37.247 |
100 |
0.379 |