Detailed information NTG0909563

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SM123_RS09825
• Genome accession: NZ_CP139419
• Coordinates: 2033558..2034292 (-)
• Length: 244 a.a.
• NCBI ID: WP_037608250.1
• Uniprot ID: A0AAX4AXY2
• Organism: Streptococcus lingualis strain S5
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 2028558..2039292

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SM123_RS09805 (SM123_09805)	-	2029746..2030279 (+)	534	WP_049474411.1	hypothetical protein	-
SM123_RS09810 (SM123_09810)	-	2030568..2031275 (-)	708	WP_320909527.1	ABC transporter	-
SM123_RS09815 (SM123_09815)	-	2031272..2031952 (-)	681	WP_320909528.1	ABC transporter ATP-binding protein	-
SM123_RS09820 (SM123_09820)	-	2032241..2033545 (-)	1305	WP_320909529.1	GHKL domain-containing protein	-
SM123_RS09825 (SM123_09825)	comE/blpR	2033558..2034292 (-)	735	WP_037608250.1	response regulator transcription factor	Regulator
SM123_RS09830 (SM123_09830)	groL	2035782..2037407 (-)	1626	WP_003004647.1	chaperonin GroEL	-
SM123_RS09835 (SM123_09835)	groES	2037429..2037710 (-)	282	WP_003013619.1	co-chaperone GroES	-
SM123_RS09840 (SM123_09840)	-	2037841..2038134 (-)	294	WP_003013750.1	hypothetical protein	-
SM123_RS09845 (SM123_09845)	-	2038236..2039090 (-)	855	WP_173018936.1	PTS system mannose/fructose/sorbose family transporter subunit IID	-

Sequence

Protein

• Length: 244 a.a.
• Molecular weight: 28203.50 Da
• Isoelectric Point: 6.6114

>NTDB_id=909563 SM123_RS09825 WP_037608250.1 2033558..2034292(-) (comE/blpR) [Streptococcus lingualis strain S5]
MLKIFVLEDEWIQQSRIEAVLQDLIRQKFLQCKAPEVFGKSSQLLDAITERGAHHLFFLDIEIKGEEKKGLEIAKEIRKK
DPHATIVFVTTHSEFMPITFQYKVAALDFIDKTLGEEEFKERISSAIDYTLEQAGTTIAQDAFTFESAMARVQVPFNKIL
YVETSPTIHKVILHTQEERLEFYASIADIEKADPRLYRCHRSFVVNPQNITKIDKEAKKAFFENGDNCLISRTKYRGLLE
ALKK

Nucleotide

• Length: 735 bp

>NTDB_id=909563 SM123_RS09825 WP_037608250.1 2033558..2034292(-) (comE/blpR) [Streptococcus lingualis strain S5]
TTGTTGAAGATTTTTGTGTTAGAAGATGAATGGATCCAACAATCGCGTATCGAAGCGGTCTTGCAGGATCTCATCCGTCA
AAAATTCTTGCAATGCAAAGCGCCAGAAGTGTTTGGGAAGTCAAGCCAGTTGCTGGATGCTATCACAGAGAGAGGCGCCC
ATCACCTATTCTTTTTAGATATCGAGATTAAAGGTGAGGAGAAAAAGGGGCTGGAGATCGCAAAAGAGATTCGTAAGAAA
GATCCCCATGCGACCATTGTCTTTGTCACCACTCACTCTGAATTTATGCCCATTACCTTTCAGTACAAAGTGGCTGCCTT
GGATTTTATCGATAAAACGCTGGGTGAGGAAGAGTTCAAAGAGAGAATCAGCTCAGCCATCGATTATACCTTGGAGCAAG
CTGGGACCACGATTGCGCAAGATGCCTTTACGTTTGAGAGTGCGATGGCGCGTGTACAAGTTCCTTTTAATAAGATTTTG
TATGTTGAAACGTCTCCAACCATTCACAAGGTCATTTTACACACCCAGGAAGAGCGCTTGGAATTTTACGCTAGTATTGC
CGATATCGAAAAAGCAGATCCCCGCTTGTATCGGTGCCACCGCTCCTTTGTGGTGAATCCGCAAAATATTACGAAGATTG
ATAAAGAAGCCAAGAAAGCTTTTTTTGAAAATGGGGACAATTGCTTGATCTCACGGACCAAGTATAGAGGCTTACTGGAA
GCTTTGAAAAAATAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-242)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	55.23	97.951	0.541
comE/comE1	Streptococcus equinus JB1	45.679	99.59	0.455
comE/comE2	Streptococcus gordonii strain NCTC7865	40.244	100	0.406
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.244	100	0.406
comE/comE2	Streptococcus equinus JB1	38.462	100	0.389
comE	Streptococcus pneumoniae TIGR4	36.4	100	0.373
comE	Streptococcus mitis SK321	36.4	100	0.373
comE	Streptococcus mitis NCTC 12261	36.4	100	0.373
comE	Streptococcus infantis strain Atu-4	36.4	100	0.373
comE	Streptococcus pneumoniae Rx1	36.4	100	0.373
comE	Streptococcus pneumoniae D39	36.4	100	0.373
comE	Streptococcus pneumoniae R6	36.4	100	0.373