Detailed information NTG0909516

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: SM123_RS00875
• Genome accession: NZ_CP139419
• Coordinates: 148610..149368 (+)
• Length: 252 a.a.
• NCBI ID: WP_003009229.1
• Uniprot ID: V8B9D8
• Organism: Streptococcus lingualis strain S5
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 143610..154368

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SM123_RS00850 (SM123_00850)	spo0J	144118..144879 (-)	762	WP_049495811.1	ParB/RepB/Spo0J family partition protein	Regulator
SM123_RS00855 (SM123_00855)	htrA	144951..146132 (-)	1182	WP_320909608.1	S1C family serine protease	Regulator
SM123_RS00860 (SM123_00860)	rlmH	146337..146816 (+)	480	WP_003009233.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SM123_RS00870 (SM123_00870)	-	147273..148613 (+)	1341	WP_214259682.1	GHKL domain-containing protein	-
SM123_RS00875 (SM123_00875)	comE/comE2	148610..149368 (+)	759	WP_003009229.1	response regulator transcription factor	Regulator
SM123_RS00890 (SM123_00890)	-	149672..152239 (-)	2568	WP_320909609.1	YfhO family protein	-
SM123_RS00895 (SM123_00895)	-	152289..153914 (-)	1626	WP_320909610.1	ATP-binding cassette domain-containing protein	-

Sequence

Protein

• Length: 252 a.a.
• Molecular weight: 29548.05 Da
• Isoelectric Point: 5.4835

>NTDB_id=909516 SM123_RS00875 WP_003009229.1 148610..149368(+) (comE/comE2) [Streptococcus lingualis strain S5]
MKIFLLEDELSQQIRVEKHIAEIAKELEIKLEVISTGKISEFENYIQHSDIHQLYFLDIHIQDNEYCGLEIAQKIREANP
YAIIVFITTKSEFASITYRYKVSALDFIDKNLNEDLFRLKIKECIEYLTTIQIGNDDLTDYFEYDFKDKKIKIPFKDILY
IETVGSAYKLNLVGKNFQKEIAGSLSDVLEKDVEERYFSPHQSFIVNRSMIIGMDKKKKQLLLKEGYSCPISRSNIKRAK
KLIEEQNLEFSA

Nucleotide

• Length: 759 bp

>NTDB_id=909516 SM123_RS00875 WP_003009229.1 148610..149368(+) (comE/comE2) [Streptococcus lingualis strain S5]
ATGAAGATTTTTTTATTAGAAGATGAGCTCTCTCAACAGATACGGGTAGAAAAACATATTGCAGAAATTGCTAAGGAATT
AGAAATTAAACTTGAAGTGATTTCTACCGGTAAAATTTCGGAATTTGAAAATTATATCCAGCATTCGGATATCCACCAAT
TATATTTTCTAGATATTCATATCCAAGACAATGAGTATTGTGGGCTGGAAATTGCTCAAAAAATACGAGAAGCAAATCCT
TATGCCATTATTGTTTTTATTACTACAAAATCAGAATTCGCTTCGATTACCTATCGTTATAAAGTATCTGCCTTAGATTT
TATTGATAAAAATTTGAATGAAGATTTATTTAGATTAAAAATCAAGGAGTGTATTGAGTACCTAACAACTATTCAAATTG
GAAATGATGATTTGACAGATTATTTTGAGTATGACTTTAAGGATAAAAAGATAAAAATTCCATTTAAGGATATTCTTTAT
ATTGAAACTGTTGGTTCGGCTTATAAATTAAACTTAGTTGGGAAAAATTTTCAAAAAGAAATTGCGGGAAGTTTATCAGA
TGTCTTGGAGAAAGATGTGGAGGAGAGATATTTCAGTCCCCATCAATCTTTTATCGTGAATAGAAGTATGATCATTGGAA
TGGATAAGAAAAAGAAACAGCTGCTGTTGAAAGAAGGGTATTCTTGTCCAATCTCAAGAAGCAATATCAAACGTGCCAAA
AAATTAATTGAAGAGCAAAATTTAGAATTTAGTGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (29-120)

• LytTr DNA-binding domain (LytTR) (149-243)

3D structure

• AlphaFold DB: V8B9D8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus gordonii strain NCTC7865	49.194	98.413	0.484
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	49.194	98.413	0.484
comE	Streptococcus pneumoniae Rx1	47.177	98.413	0.464
comE	Streptococcus pneumoniae D39	47.177	98.413	0.464
comE	Streptococcus pneumoniae R6	47.177	98.413	0.464
comE	Streptococcus pneumoniae TIGR4	47.177	98.413	0.464
comE	Streptococcus mitis NCTC 12261	47.177	98.413	0.464
comE	Streptococcus mitis SK321	47.177	98.413	0.464
comE	Streptococcus infantis strain Atu-4	45.968	98.413	0.452
comE/blpR	Streptococcus mutans UA159	38.866	98.016	0.381