Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   SM123_RS00855 Genome accession   NZ_CP139419
Coordinates   144951..146132 (-) Length   393 a.a.
NCBI ID   WP_320909608.1    Uniprot ID   -
Organism   Streptococcus lingualis strain S5     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 139951..151132
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SM123_RS00830 (SM123_00830) - 140459..140956 (+) 498 WP_320909607.1 DUF1307 domain-containing protein -
  SM123_RS00835 (SM123_00835) - 140992..141183 (-) 192 WP_003002008.1 DUF951 domain-containing protein -
  SM123_RS00840 (SM123_00840) dnaN 141196..142332 (-) 1137 WP_070449649.1 DNA polymerase III subunit beta -
  SM123_RS00845 (SM123_00845) dnaA 142492..143850 (-) 1359 WP_070449645.1 chromosomal replication initiator protein DnaA -
  SM123_RS00850 (SM123_00850) spo0J 144118..144879 (-) 762 WP_049495811.1 ParB/RepB/Spo0J family partition protein Regulator
  SM123_RS00855 (SM123_00855) htrA 144951..146132 (-) 1182 WP_320909608.1 S1C family serine protease Regulator
  SM123_RS00860 (SM123_00860) rlmH 146337..146816 (+) 480 WP_003009233.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  SM123_RS00870 (SM123_00870) - 147273..148613 (+) 1341 WP_214259682.1 GHKL domain-containing protein -
  SM123_RS00875 (SM123_00875) comE/comE2 148610..149368 (+) 759 WP_003009229.1 response regulator transcription factor Regulator

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41704.81 Da        Isoelectric Point: 5.7871

>NTDB_id=909515 SM123_RS00855 WP_320909608.1 144951..146132(-) (htrA) [Streptococcus lingualis strain S5]
MKSSSNLLKKLGNIALIFVVGFLGGILGTFLTLQTSHSSTSNTESKQVHSTTVKTAYKNTTSTSEAVDKVKNAVVSVITY
SDSSNQGLFEKEENSDSQISSEGSGVIYKKEGKYAYLVTNTHVINGAKKVDILLADGNKVPGEVVGSDVYSDIAVVRISA
DKAKAVAEFGDSNQLTVGETAIAIGSPLGTDYANSVTQGIISSQGRNVKLKADNGQNISTRALQTDAAINPGNSGGPLIN
IQGQVIGITSSKISNNGQTSVEGMGFAIPANDVVNIIKQLEEKGKVVRPALGIQMMDLSNLSTSDLSQLKLPEKISGGVL
VRSTLENMPASDKLQRYDVITKIDDTDIESTADLQSALYSHQINDTIKVTFYRDGKQQTTSIKLTKSTEDLSD

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=909515 SM123_RS00855 WP_320909608.1 144951..146132(-) (htrA) [Streptococcus lingualis strain S5]
ATGAAATCTTCATCTAATTTACTGAAAAAACTTGGAAACATAGCCCTCATTTTTGTTGTAGGTTTTCTAGGTGGTATTCT
TGGAACCTTTTTAACCTTACAAACCTCTCATTCTTCTACTTCAAATACTGAAAGTAAGCAAGTCCACTCAACCACTGTTA
AAACAGCTTATAAAAATACAACCTCAACTAGTGAGGCCGTAGACAAGGTGAAAAATGCTGTAGTTTCTGTGATTACTTAT
TCTGATTCTTCGAATCAAGGGTTATTTGAAAAAGAAGAAAACTCTGACTCACAAATTTCTAGTGAAGGTTCTGGGGTCAT
TTATAAAAAAGAAGGAAAATATGCCTACCTTGTTACCAACACCCATGTCATCAATGGTGCTAAAAAAGTAGACATTCTTT
TAGCAGATGGGAATAAAGTCCCTGGAGAAGTAGTTGGATCAGATGTCTATTCTGATATTGCAGTCGTTCGCATTAGTGCG
GATAAAGCAAAGGCAGTAGCTGAATTCGGAGATTCAAACCAATTAACAGTCGGTGAGACTGCAATTGCAATTGGTAGCCC
TCTTGGAACAGATTATGCTAATTCTGTTACCCAAGGGATTATTTCCAGCCAAGGCCGCAATGTGAAATTGAAAGCCGATA
ATGGACAAAATATCTCTACACGCGCCCTACAAACAGACGCAGCCATCAACCCAGGAAACTCTGGAGGTCCATTAATCAAT
ATTCAAGGACAAGTCATCGGGATTACCTCAAGTAAAATTTCAAATAATGGACAAACTTCAGTAGAAGGAATGGGATTTGC
TATTCCTGCAAATGATGTTGTCAATATTATCAAACAGCTAGAAGAAAAAGGAAAAGTAGTTCGACCAGCTCTTGGAATCC
AAATGATGGATTTATCCAACCTTTCAACTTCTGATTTAAGCCAATTAAAACTTCCTGAAAAAATCTCTGGAGGAGTACTG
GTTCGTTCAACACTTGAAAATATGCCTGCTTCAGATAAATTGCAACGCTATGATGTCATCACAAAGATCGATGATACAGA
TATCGAGTCAACTGCAGATTTACAATCCGCCCTCTATTCTCACCAAATCAATGATACAATCAAGGTCACATTCTATCGTG
ATGGAAAACAACAAACAACTTCTATCAAGTTGACAAAATCAACTGAGGATCTGAGCGATTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

PDZ domain (PDZ_2)

(289-384)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

68.09

100

0.69
  htrA Streptococcus mitis NCTC 12261

63.359

100

0.634
  htrA Streptococcus pneumoniae Rx1

63.359

100

0.634
  htrA Streptococcus pneumoniae D39

63.359

100

0.634
  htrA Streptococcus pneumoniae R6

63.359

100

0.634
  htrA Streptococcus pneumoniae TIGR4

63.359

100

0.634
  htrA Streptococcus mutans UA159

54.026

97.964

0.529