Detailed information NTG0909464

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SM121_RS00945
• Genome accession: NZ_CP139418
• Coordinates: 200352..201086 (-)
• Length: 244 a.a.
• NCBI ID: WP_031577029.1
• Uniprot ID: A0A414JUW7
• Organism: Streptococcus dentalis strain S1
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 195352..206086

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SM121_RS00925 (SM121_00925)	-	196631..197161 (+)	531	WP_129824460.1	hypothetical protein	-
SM121_RS00930 (SM121_00930)	-	197361..198068 (-)	708	WP_320910973.1	ABC transporter	-
SM121_RS00935 (SM121_00935)	-	198065..198745 (-)	681	WP_320910974.1	ABC transporter ATP-binding protein	-
SM121_RS00940 (SM121_00940)	-	199034..200320 (-)	1287	WP_238676505.1	sensor histidine kinase	-
SM121_RS00945 (SM121_00945)	comE/blpR	200352..201086 (-)	735	WP_031577029.1	response regulator transcription factor	Regulator
SM121_RS00950 (SM121_00950)	groL	201963..203588 (-)	1626	WP_003004647.1	chaperonin GroEL	-
SM121_RS00955 (SM121_00955)	groES	203610..203891 (-)	282	WP_024055367.1	co-chaperone GroES	-
SM121_RS00960 (SM121_00960)	-	204021..204314 (-)	294	WP_003004348.1	hypothetical protein	-
SM121_RS00965 (SM121_00965)	-	204416..205270 (-)	855	WP_037585172.1	PTS system mannose/fructose/sorbose family transporter subunit IID	-

Sequence

Protein

• Length: 244 a.a.
• Molecular weight: 28102.30 Da
• Isoelectric Point: 6.3932

>NTDB_id=909464 SM121_RS00945 WP_031577029.1 200352..201086(-) (comE/blpR) [Streptococcus dentalis strain S1]
MLKIFVLEDEWIQQSRIESVLQELIAQKSLQCKAPEVFGKSSQLLDAITERGAHHLFFLDIEIKGEEKKGLEIAKEIRKK
DPHATIVFVTTHSEFMPITFQYKVAALDFIDKTLGEEEFRERISSAIDYTLEQAGTTIAQDAFTFESAMARVQVPFNKIL
YVETSPTIHKVILHTQDERLEFYASIADIEKADPRLYRCHRSFVVNPQNITKIDKEAKKAFFENGDNCLISRTKYRGLLE
ALKK

Nucleotide

• Length: 735 bp

>NTDB_id=909464 SM121_RS00945 WP_031577029.1 200352..201086(-) (comE/blpR) [Streptococcus dentalis strain S1]
TTGTTGAAGATTTTTGTGTTAGAAGATGAGTGGATCCAGCAATCACGAATCGAATCGGTCTTGCAGGAACTTATCGCTCA
GAAGTCCTTGCAATGCAAAGCGCCAGAAGTGTTTGGGAAATCAAGCCAGTTGCTAGATGCTATCACAGAGAGAGGCGCTC
ATCACCTATTCTTTTTAGATATCGAGATTAAAGGTGAGGAGAAAAAAGGTCTGGAGATTGCAAAAGAGATTCGTAAGAAA
GACCCCCATGCGACCATTGTCTTTGTCACCACTCACTCTGAATTCATGCCCATTACCTTTCAGTACAAAGTAGCCGCCTT
GGATTTTATCGATAAAACGCTGGGTGAGGAAGAGTTCAGAGAGAGAATCAGCTCAGCCATCGATTATACCTTGGAGCAAG
CTGGGACCACGATTGCACAAGATGCTTTTACATTTGAGAGTGCGATGGCGCGTGTACAAGTTCCCTTTAATAAGATTTTG
TATGTTGAAACGTCTCCAACTATTCACAAGGTCATTTTACACACCCAGGATGAGCGCTTGGAATTTTACGCTAGTATTGC
CGATATCGAAAAAGCAGATCCCCGCTTGTATCGGTGCCACCGCTCCTTTGTGGTGAATCCACAAAATATTACGAAGATTG
ATAAGGAAGCCAAGAAAGCTTTTTTTGAAAATGGGGACAATTGCTTGATCTCACGGACCAAGTATAGAGGCTTACTGGAA
GCTTTGAAAAAATAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-242)

3D structure

• AlphaFold DB: A0A414JUW7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	55.649	97.951	0.545
comE/comE1	Streptococcus equinus JB1	45.679	99.59	0.455
comE/comE2	Streptococcus gordonii strain NCTC7865	39.837	100	0.402
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.837	100	0.402
comE/comE2	Streptococcus equinus JB1	37.652	100	0.381
comE	Streptococcus pneumoniae R6	36.4	100	0.373
comE	Streptococcus pneumoniae TIGR4	36.4	100	0.373
comE	Streptococcus mitis NCTC 12261	36.4	100	0.373
comE	Streptococcus infantis strain Atu-4	36.4	100	0.373
comE	Streptococcus mitis SK321	36.4	100	0.373
comE	Streptococcus pneumoniae Rx1	36.4	100	0.373
comE	Streptococcus pneumoniae D39	36.4	100	0.373