Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   R4712_RS06865 Genome accession   NZ_CP137110
Coordinates   1348977..1350233 (+) Length   418 a.a.
NCBI ID   WP_000642704.1    Uniprot ID   C1CTH7
Organism   Streptococcus pneumoniae strain 16H2041     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1336906..1368109 1348977..1350233 within 0


Gene organization within MGE regions


Location: 1336906..1368109
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4712_RS06805 - 1336906..1339014 (-) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  R4712_RS06810 - 1339011..1339940 (-) 930 WP_000912954.1 M50 family metallopeptidase -
  R4712_RS06815 - 1339921..1340625 (-) 705 WP_001033170.1 flavodoxin family protein -
  R4712_RS06820 - 1340975..1343965 (-) 2991 WP_000875571.1 type 2 lanthipeptide synthetase LanM family protein -
  R4712_RS06825 pneA2 1344081..1344269 (-) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  R4712_RS06830 pneA1 1344276..1344500 (-) 225 WP_044812438.1 two-peptide bacteriocin subunit PneA1 -
  R4712_RS06835 - 1344603..1344773 (-) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  R4712_RS06840 - 1344965..1345828 (+) 864 WP_044812437.1 helix-turn-helix domain-containing protein -
  R4712_RS06845 comM 1346211..1346831 (+) 621 WP_044812436.1 hypothetical protein Regulator
  R4712_RS06850 tsaE 1346917..1347360 (+) 444 WP_000288230.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  R4712_RS06855 - 1347350..1347868 (+) 519 WP_000455536.1 GNAT family N-acetyltransferase -
  R4712_RS06860 brpA 1347876..1348892 (+) 1017 WP_000239278.1 biofilm formation/cell division transcriptional regulator BrpA -
  R4712_RS06865 cinA 1348977..1350233 (+) 1257 WP_000642704.1 competence/damage-inducible protein A Machinery gene
  R4712_RS06870 recA 1350288..1351454 (+) 1167 WP_044812435.1 recombinase RecA Machinery gene
  R4712_RS06875 - 1351760..1353130 (+) 1371 WP_044812432.1 MATE family efflux transporter -
  R4712_RS06880 lytA 1353506..1354462 (+) 957 WP_000405234.1 N-acetylmuramoyl-L-alanine amidase LytA -
  R4712_RS06885 - 1354808..1354969 (+) 162 WP_001055999.1 helix-turn-helix domain-containing protein -
  R4712_RS06890 - 1354956..1355567 (+) 612 WP_224757294.1 ImmA/IrrE family metallo-endopeptidase -
  R4712_RS06895 - 1355696..1356121 (+) 426 WP_000204067.1 hypothetical protein -
  R4712_RS06900 - 1356529..1357323 (+) 795 WP_001101196.1 hypothetical protein -
  R4712_RS06905 - 1357327..1357524 (+) 198 WP_044812849.1 hypothetical protein -
  R4712_RS06910 - 1357514..1358065 (+) 552 WP_044812848.1 hypothetical protein -
  R4712_RS06915 - 1358124..1358384 (+) 261 WP_001209197.1 hypothetical protein -
  R4712_RS06920 - 1359122..1359925 (-) 804 WP_078372244.1 IS5 family transposase -
  R4712_RS06925 - 1360084..1362111 (-) 2028 WP_044812833.1 ABC transporter substrate-binding protein -
  R4712_RS06930 - 1362121..1362720 (-) 600 WP_001021235.1 HAD family phosphatase -
  R4712_RS06935 - 1362767..1363468 (-) 702 WP_001054457.1 MgtC/SapB family protein -
  R4712_RS06940 - 1363470..1365164 (-) 1695 WP_001232284.1 iron ABC transporter permease -
  R4712_RS06945 - 1365176..1366180 (-) 1005 WP_000627602.1 ABC transporter ATP-binding protein -
  R4712_RS06950 - 1366197..1367258 (-) 1062 WP_000475762.1 extracellular solute-binding protein -
  R4712_RS06955 - 1367216..1368109 (-) 894 WP_001841509.1 glycerophosphodiester phosphodiesterase family protein -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45089.42 Da        Isoelectric Point: 4.5211

>NTDB_id=895886 R4712_RS06865 WP_000642704.1 1348977..1350233(+) (cinA) [Streptococcus pneumoniae strain 16H2041]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGNKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=895886 R4712_RS06865 WP_000642704.1 1348977..1350233(+) (cinA) [Streptococcus pneumoniae strain 16H2041]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAACAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTGAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Competence-damaged protein (CinA)

(262-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C1CTH7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae Rx1

99.522

100

0.995
  cinA Streptococcus pneumoniae R6

99.522

100

0.995
  cinA Streptococcus pneumoniae TIGR4

99.282

100

0.993
  cinA Streptococcus pneumoniae D39

99.282

100

0.993
  cinA Streptococcus mitis SK321

93.301

100

0.933
  cinA Streptococcus mitis NCTC 12261

93.062

100

0.931
  cinA Streptococcus mutans UA159

70.813

100

0.708
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455