Detailed information    

insolico Bioinformatically predicted

Overview

Name   comM   Type   Regulator
Locus tag   R4712_RS06845 Genome accession   NZ_CP137110
Coordinates   1346211..1346831 (+) Length   206 a.a.
NCBI ID   WP_044812436.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 16H2041     
Function   fratricide immunity (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1336906..1368109 1346211..1346831 within 0


Gene organization within MGE regions


Location: 1336906..1368109
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4712_RS06805 - 1336906..1339014 (-) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  R4712_RS06810 - 1339011..1339940 (-) 930 WP_000912954.1 M50 family metallopeptidase -
  R4712_RS06815 - 1339921..1340625 (-) 705 WP_001033170.1 flavodoxin family protein -
  R4712_RS06820 - 1340975..1343965 (-) 2991 WP_000875571.1 type 2 lanthipeptide synthetase LanM family protein -
  R4712_RS06825 pneA2 1344081..1344269 (-) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  R4712_RS06830 pneA1 1344276..1344500 (-) 225 WP_044812438.1 two-peptide bacteriocin subunit PneA1 -
  R4712_RS06835 - 1344603..1344773 (-) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  R4712_RS06840 - 1344965..1345828 (+) 864 WP_044812437.1 helix-turn-helix domain-containing protein -
  R4712_RS06845 comM 1346211..1346831 (+) 621 WP_044812436.1 hypothetical protein Regulator
  R4712_RS06850 tsaE 1346917..1347360 (+) 444 WP_000288230.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  R4712_RS06855 - 1347350..1347868 (+) 519 WP_000455536.1 GNAT family N-acetyltransferase -
  R4712_RS06860 brpA 1347876..1348892 (+) 1017 WP_000239278.1 biofilm formation/cell division transcriptional regulator BrpA -
  R4712_RS06865 cinA 1348977..1350233 (+) 1257 WP_000642704.1 competence/damage-inducible protein A Machinery gene
  R4712_RS06870 recA 1350288..1351454 (+) 1167 WP_044812435.1 recombinase RecA Machinery gene
  R4712_RS06875 - 1351760..1353130 (+) 1371 WP_044812432.1 MATE family efflux transporter -
  R4712_RS06880 lytA 1353506..1354462 (+) 957 WP_000405234.1 N-acetylmuramoyl-L-alanine amidase LytA -
  R4712_RS06885 - 1354808..1354969 (+) 162 WP_001055999.1 helix-turn-helix domain-containing protein -
  R4712_RS06890 - 1354956..1355567 (+) 612 WP_224757294.1 ImmA/IrrE family metallo-endopeptidase -
  R4712_RS06895 - 1355696..1356121 (+) 426 WP_000204067.1 hypothetical protein -
  R4712_RS06900 - 1356529..1357323 (+) 795 WP_001101196.1 hypothetical protein -
  R4712_RS06905 - 1357327..1357524 (+) 198 WP_044812849.1 hypothetical protein -
  R4712_RS06910 - 1357514..1358065 (+) 552 WP_044812848.1 hypothetical protein -
  R4712_RS06915 - 1358124..1358384 (+) 261 WP_001209197.1 hypothetical protein -
  R4712_RS06920 - 1359122..1359925 (-) 804 WP_078372244.1 IS5 family transposase -
  R4712_RS06925 - 1360084..1362111 (-) 2028 WP_044812833.1 ABC transporter substrate-binding protein -
  R4712_RS06930 - 1362121..1362720 (-) 600 WP_001021235.1 HAD family phosphatase -
  R4712_RS06935 - 1362767..1363468 (-) 702 WP_001054457.1 MgtC/SapB family protein -
  R4712_RS06940 - 1363470..1365164 (-) 1695 WP_001232284.1 iron ABC transporter permease -
  R4712_RS06945 - 1365176..1366180 (-) 1005 WP_000627602.1 ABC transporter ATP-binding protein -
  R4712_RS06950 - 1366197..1367258 (-) 1062 WP_000475762.1 extracellular solute-binding protein -
  R4712_RS06955 - 1367216..1368109 (-) 894 WP_001841509.1 glycerophosphodiester phosphodiesterase family protein -

Sequence

Protein


Download         Length: 206 a.a.        Molecular weight: 23566.74 Da        Isoelectric Point: 10.1254

>NTDB_id=895885 R4712_RS06845 WP_044812436.1 1346211..1346831(+) (comM) [Streptococcus pneumoniae strain 16H2041]
MKLMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF

Nucleotide


Download         Length: 621 bp        

>NTDB_id=895885 R4712_RS06845 WP_044812436.1 1346211..1346831(+) (comM) [Streptococcus pneumoniae strain 16H2041]
ATGAAATTAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comM Streptococcus pneumoniae D39

99.029

100

0.99
  comM Streptococcus pneumoniae R6

99.029

100

0.99
  comM Streptococcus pneumoniae TIGR4

99.029

100

0.99
  comM Streptococcus mitis NCTC 12261

38.462

94.66

0.364
  comM Streptococcus mitis SK321

38.462

94.66

0.364