NTDB

Overview

Name	comE/blpR	Type	Regulator
Locus tag	R3H37_RS07110	Genome accession	NZ_CP136948
Coordinates	1436849..1437598 (-)	Length	249 a.a.
NCBI ID	WP_030126108.1	Uniprot ID	A0A223M029
Organism	Streptococcus pyogenes strain Spyo01
Function	activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	1424331..1440365	1436849..1437598	within	0

Gene organization within MGE regions

Location: 1424331..1440365

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R3H37_RS07035 (R3H37_07040)	-	1424331..1425521 (+)	1191	WP_002299749.1	IS256-like element ISLgar5 family transposase	-
R3H37_RS07040 (R3H37_07045)	-	1425561..1425851 (-)	291	Protein_1333	hypothetical protein	-
R3H37_RS07045 (R3H37_07050)	-	1426045..1426326 (-)	282	WP_111705488.1	hypothetical protein	-
R3H37_RS07050 (R3H37_07055)	-	1426376..1426570 (-)	195	WP_002990768.1	hypothetical protein	-
R3H37_RS07055 (R3H37_07060)	-	1426864..1427064 (-)	201	WP_003060803.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
R3H37_RS07060 (R3H37_07065)	-	1427077..1427304 (-)	228	WP_002992018.1	Blp family class II bacteriocin	-
R3H37_RS07065 (R3H37_07070)	-	1427622..1428307 (+)	686	Protein_1338	transposase	-
R3H37_RS07070 (R3H37_07075)	-	1428527..1428709 (-)	183	WP_002987564.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
R3H37_RS07075 (R3H37_07080)	-	1428724..1428969 (-)	246	WP_002994504.1	Blp family class II bacteriocin	-
R3H37_RS07080 (R3H37_07085)	-	1429156..1429841 (-)	686	Protein_1341	transposase	-
R3H37_RS07085 (R3H37_07090)	comA/nlmT	1430292..1432445 (+)	2154	WP_129284363.1	peptide cleavage/export ABC transporter	Regulator
R3H37_RS07090 (R3H37_07095)	-	1432456..1433820 (+)	1365	WP_330554621.1	bacteriocin secretion accessory protein	-
R3H37_RS07095 (R3H37_07100)	-	1433897..1434022 (+)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
R3H37_RS07100 (R3H37_07105)	-	1434246..1435436 (-)	1191	WP_002299749.1	IS256-like element ISLgar5 family transposase	-
R3H37_RS07105 (R3H37_07110)	-	1435475..1436848 (-)	1374	WP_330554622.1	sensor histidine kinase	-
R3H37_RS07110 (R3H37_07115)	comE/blpR	1436849..1437598 (-)	750	WP_030126108.1	response regulator transcription factor	Regulator
R3H37_RS07115 (R3H37_07120)	-	1437833..1439326 (-)	1494	WP_373935149.1	IS1182 family transposase	-

Sequence

Protein

Download Length: 249 a.a. Molecular weight: 29141.44 Da Isoelectric Point: 5.8302

                                >NTDB_id=893619 R3H37_RS07110 WP_030126108.1 1436849..1437598(-) (comE/blpR) [Streptococcus pyogenes strain Spyo01]

MNIFVLEDDFLHQTRIEKIIYKILTDNKLEVNHLEVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNKD

PHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFTNVKSQIQVSFSDLLY

IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV

VEELHTKEK

Nucleotide

Download Length: 750 bp

                                >NTDB_id=893619 R3H37_RS07110 WP_030126108.1 1436849..1437598(-) (comE/blpR) [Streptococcus pyogenes strain Spyo01]

ATGAATATTTTTGTCTTAGAGGACGATTTTTTACATCAAACCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA

TAAGTTGGAGGTTAACCACTTGGAAGTTTATGGTAAACCCAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC

AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAAAGAT

CCGCACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTATCTTTTCAATACCAGGTTTCAGCTTTAGA

CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG

GAAAAACGTTAGCGGAGGATTCATTTGTTTTTACTAATGTAAAGTCCCAGATACAAGTCTCCTTTTCAGATTTGCTGTAT

ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA

AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTCAATCCCTATAATATATCATCAATAGATA

GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA

GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(150-239)

Response regulator receiver domain (Response_reg)

(3-119)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A223M029

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comE/blpR	Streptococcus mutans UA159	54.098	97.992	0.53
comE/comE2	Streptococcus gordonii strain NCTC7865	40.476	100	0.41
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.476	100	0.41
comE/comE1	Streptococcus equinus JB1	42.437	95.582	0.406
comE/comE2	Streptococcus equinus JB1	40.574	97.992	0.398
comE	Streptococcus mitis NCTC 12261	38.4	100	0.386
comE	Streptococcus mitis SK321	38.4	100	0.386
comE	Streptococcus pneumoniae TIGR4	38	100	0.382
comE	Streptococcus pneumoniae Rx1	38	100	0.382
comE	Streptococcus pneumoniae D39	38	100	0.382
comE	Streptococcus pneumoniae R6	38	100	0.382
comE	Streptococcus infantis strain Atu-4	37.903	99.598	0.378

Detailed information NTG0893619