Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/comE2   Type   Regulator
Locus tag   RDV49_RS02465 Genome accession   NZ_CP133988
Coordinates   477235..477993 (+) Length   252 a.a.
NCBI ID   WP_003009229.1    Uniprot ID   V8B9D8
Organism   Streptococcus parasanguinis strain B-1756     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 472235..482993
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RDV49_RS02440 (RDV49_02440) spo0J 472739..473500 (-) 762 WP_003009236.1 ParB/RepB/Spo0J family partition protein Regulator
  RDV49_RS02445 (RDV49_02445) htrA 473572..474753 (-) 1182 WP_003009234.1 S1C family serine protease Regulator
  RDV49_RS02450 (RDV49_02450) rlmH 474958..475437 (+) 480 WP_003009233.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  RDV49_RS02460 (RDV49_02460) - 475898..477238 (+) 1341 WP_003009231.1 GHKL domain-containing protein -
  RDV49_RS02465 (RDV49_02465) comE/comE2 477235..477993 (+) 759 WP_003009229.1 response regulator transcription factor Regulator
  RDV49_RS02480 (RDV49_02480) - 478297..480864 (-) 2568 WP_003009226.1 YfhO family protein -
  RDV49_RS02485 (RDV49_02485) - 480914..482539 (-) 1626 WP_003009224.1 ATP-binding cassette domain-containing protein -

Sequence

Protein


Download         Length: 252 a.a.        Molecular weight: 29548.05 Da        Isoelectric Point: 5.4835

>NTDB_id=878155 RDV49_RS02465 WP_003009229.1 477235..477993(+) (comE/comE2) [Streptococcus parasanguinis strain B-1756]
MKIFLLEDELSQQIRVEKHIAEIAKELEIKLEVISTGKISEFENYIQHSDIHQLYFLDIHIQDNEYCGLEIAQKIREANP
YAIIVFITTKSEFASITYRYKVSALDFIDKNLNEDLFRLKIKECIEYLTTIQIGNDDLTDYFEYDFKDKKIKIPFKDILY
IETVGSAYKLNLVGKNFQKEIAGSLSDVLEKDVEERYFSPHQSFIVNRSMIIGMDKKKKQLLLKEGYSCPISRSNIKRAK
KLIEEQNLEFSA

Nucleotide


Download         Length: 759 bp        

>NTDB_id=878155 RDV49_RS02465 WP_003009229.1 477235..477993(+) (comE/comE2) [Streptococcus parasanguinis strain B-1756]
ATGAAGATTTTTTTATTAGAAGATGAGCTCTCTCAACAGATACGGGTAGAAAAACATATTGCAGAAATTGCTAAGGAATT
AGAAATTAAACTTGAAGTGATTTCTACCGGTAAAATTTCGGAATTTGAAAATTATATCCAACATTCGGATATCCACCAAT
TATATTTTCTAGATATTCATATCCAAGACAATGAGTATTGTGGGCTGGAAATTGCTCAAAAAATACGAGAAGCAAATCCT
TATGCCATTATTGTTTTTATTACTACAAAATCAGAATTCGCTTCGATTACCTATCGTTATAAAGTATCTGCCTTAGATTT
TATTGATAAAAATTTGAATGAAGATTTATTTAGATTAAAAATCAAGGAGTGTATTGAGTACCTAACAACTATTCAAATTG
GAAATGATGATTTGACAGATTATTTTGAGTATGACTTTAAGGATAAAAAGATAAAAATTCCATTTAAGGATATTCTTTAT
ATTGAAACTGTTGGTTCGGCTTATAAATTAAACTTAGTTGGGAAAAATTTTCAAAAAGAAATTGCGGGAAGTTTATCAGA
TGTCTTGGAGAAAGATGTGGAGGAGAGATATTTCAGTCCCCATCAATCTTTTATCGTGAATAGAAGTATGATCATTGGAA
TGGATAAGAAAAAGAAACAGCTGCTGTTGAAAGAAGGGTATTCTTGTCCAATCTCAAGAAGCAATATCAAACGTGCCAAA
AAATTAATTGAAGAGCAAAATTTAGAATTTAGTGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(29-120)

LytTr DNA-binding domain (LytTR)

(149-243)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB V8B9D8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/comE2 Streptococcus gordonii strain NCTC7865

49.194

98.413

0.484
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

49.194

98.413

0.484
  comE Streptococcus pneumoniae Rx1

47.177

98.413

0.464
  comE Streptococcus pneumoniae D39

47.177

98.413

0.464
  comE Streptococcus pneumoniae R6

47.177

98.413

0.464
  comE Streptococcus pneumoniae TIGR4

47.177

98.413

0.464
  comE Streptococcus mitis NCTC 12261

47.177

98.413

0.464
  comE Streptococcus mitis SK321

47.177

98.413

0.464
  comE Streptococcus infantis strain Atu-4

45.968

98.413

0.452
  comE/blpR Streptococcus mutans UA159

38.866

98.016

0.381