Detailed information NTG0840537

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: VKP53_RS06995
• Genome accession: NZ_CP142354
• Coordinates: 1411611..1412360 (-)
• Length: 249 a.a.
• NCBI ID: WP_002992578.1
• Uniprot ID: Q8P262
• Organism: Streptococcus pyogenes strain 6745-99
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1406611..1417360

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VKP53_RS06980 (VKP53_06980)	-	1408562..1409926 (+)	1365	WP_136019065.1	bacteriocin secretion accessory protein	-
VKP53_RS06985 (VKP53_06985)	-	1410003..1410128 (+)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
VKP53_RS06990 (VKP53_06990)	-	1410276..1411610 (-)	1335	WP_326674743.1	sensor histidine kinase	-
VKP53_RS06995 (VKP53_06995)	comE/blpR	1411611..1412360 (-)	750	WP_002992578.1	response regulator transcription factor	Regulator
VKP53_RS07000 (VKP53_07000)	-	1412595..1414089 (-)	1495	Protein_1328	IS1182 family transposase	-
VKP53_RS07005 (VKP53_07005)	-	1414302..1415386 (-)	1085	Protein_1329	IS3 family transposase	-
VKP53_RS07010 (VKP53_07010)	-	1415506..1415823 (-)	318	WP_002994587.1	hypothetical protein	-
VKP53_RS07015 (VKP53_07015)	-	1415872..1416099 (-)	228	WP_028797129.1	Blp family class II bacteriocin	-
VKP53_RS07020 (VKP53_07020)	-	1416497..1416625 (-)	129	WP_002994583.1	hypothetical protein	-
VKP53_RS09065	-	1416710..1416985 (-)	276	Protein_1333	lysostaphin resistance A-like protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29191.55 Da
• Isoelectric Point: 5.8302

>NTDB_id=840537 VKP53_RS06995 WP_002992578.1 1411611..1412360(-) (comE/blpR) [Streptococcus pyogenes strain 6745-99]
MNIFVLEDDFLHQTRIEKIIYKILTDNKLEVNHLEVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNRD
PHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFINVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide

• Length: 750 bp

>NTDB_id=840537 VKP53_RS06995 WP_002992578.1 1411611..1412360(-) (comE/blpR) [Streptococcus pyogenes strain 6745-99]
ATGAATATTTTTGTCTTAGAGGACGATTTTTTACATCAAACCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTTGGAGGTTAACCACTTGGAAGTTTATGGTAAACCCAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAGAGAT
CCGCACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTATCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTATTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (150-239)

• Response regulator receiver domain (Response_reg) (3-119)

3D structure

• AlphaFold DB: Q8P262

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.508	97.992	0.534
comE/comE2	Streptococcus gordonii strain NCTC7865	40.873	100	0.414
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.873	100	0.414
comE/comE1	Streptococcus equinus JB1	42.017	95.582	0.402
comE/comE2	Streptococcus equinus JB1	40.574	97.992	0.398
comE	Streptococcus mitis NCTC 12261	38.8	100	0.39
comE	Streptococcus mitis SK321	38.8	100	0.39
comE	Streptococcus pneumoniae TIGR4	38.4	100	0.386
comE	Streptococcus pneumoniae Rx1	38.4	100	0.386
comE	Streptococcus pneumoniae D39	38.4	100	0.386
comE	Streptococcus pneumoniae R6	38.4	100	0.386
comE	Streptococcus infantis strain Atu-4	38.095	100	0.386