Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   R3H37_RS07110 Genome accession   NZ_CP136948
Coordinates   1436849..1437598 (-) Length   249 a.a.
NCBI ID   WP_030126108.1    Uniprot ID   A0A223M029
Organism   Streptococcus pyogenes strain Spyo01     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1431849..1442598
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R3H37_RS07090 (R3H37_07095) - 1432456..1433820 (+) 1365 WP_330554621.1 bacteriocin secretion accessory protein -
  R3H37_RS07095 (R3H37_07100) - 1433897..1434022 (+) 126 WP_011017462.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  R3H37_RS07100 (R3H37_07105) - 1434246..1435436 (-) 1191 WP_002299749.1 IS256-like element ISLgar5 family transposase -
  R3H37_RS07105 (R3H37_07110) - 1435475..1436848 (-) 1374 WP_330554622.1 sensor histidine kinase -
  R3H37_RS07110 (R3H37_07115) comE/blpR 1436849..1437598 (-) 750 WP_030126108.1 response regulator transcription factor Regulator
  R3H37_RS07115 (R3H37_07120) - 1437833..1439326 (-) 1494 WP_373935149.1 IS1182 family transposase -
  R3H37_RS07120 (R3H37_07125) - 1439535..1440625 (-) 1091 Protein_1349 IS3 family transposase -
  R3H37_RS07125 (R3H37_07130) - 1440745..1441062 (-) 318 WP_002994587.1 hypothetical protein -
  R3H37_RS07130 (R3H37_07135) - 1441111..1441338 (-) 228 WP_028797129.1 Blp family class II bacteriocin -
  R3H37_RS07135 (R3H37_07140) - 1441736..1441864 (-) 129 WP_002994583.1 hypothetical protein -
  R3H37_RS09035 - 1441949..1442260 (-) 312 WP_227868558.1 CPBP family intramembrane glutamic endopeptidase -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29141.44 Da        Isoelectric Point: 5.8302

>NTDB_id=816469 R3H37_RS07110 WP_030126108.1 1436849..1437598(-) (comE/blpR) [Streptococcus pyogenes strain Spyo01]
MNIFVLEDDFLHQTRIEKIIYKILTDNKLEVNHLEVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNKD
PHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFTNVKSQIQVSFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide


Download         Length: 750 bp        

>NTDB_id=816469 R3H37_RS07110 WP_030126108.1 1436849..1437598(-) (comE/blpR) [Streptococcus pyogenes strain Spyo01]
ATGAATATTTTTGTCTTAGAGGACGATTTTTTACATCAAACCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTTGGAGGTTAACCACTTGGAAGTTTATGGTAAACCCAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAAAGAT
CCGCACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTATCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTACTAATGTAAAGTCCCAGATACAAGTCTCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTCAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterProScan.

LytTr DNA-binding domain (LytTR)

(150-239)

Response regulator receiver domain (Response_reg)

(3-119)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A223M029

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.098

97.992

0.53
  comE/comE2 Streptococcus gordonii strain NCTC7865

40.476

100

0.41
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

40.476

100

0.41
  comE/comE1 Streptococcus equinus JB1

42.437

95.582

0.406
  comE/comE2 Streptococcus equinus JB1

40.574

97.992

0.398
  comE Streptococcus mitis NCTC 12261

38.4

100

0.386
  comE Streptococcus mitis SK321

38.4

100

0.386
  comE Streptococcus pneumoniae TIGR4

38

100

0.382
  comE Streptococcus pneumoniae Rx1

38

100

0.382
  comE Streptococcus pneumoniae D39

38

100

0.382
  comE Streptococcus pneumoniae R6

38

100

0.382
  comE Streptococcus infantis strain Atu-4

37.903

99.598

0.378