Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   P2T63_RS10725 Genome accession   NZ_CP120352
Coordinates   2165886..2166623 (-) Length   245 a.a.
NCBI ID   WP_004049924.1    Uniprot ID   A0AAE6WG22
Organism   Ligilactobacillus murinus strain PG1-1-10     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 2154446..2166623 2165886..2166623 within 0


Gene organization within MGE regions


Location: 2154446..2166623
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P2T63_RS10640 (P2T63_10640) - 2154446..2154592 (-) 147 WP_004049945.1 hypothetical protein -
  P2T63_RS10645 (P2T63_10645) - 2154606..2154740 (-) 135 WP_004049944.1 hypothetical protein -
  P2T63_RS10650 (P2T63_10650) - 2154724..2154963 (-) 240 WP_276507854.1 hypothetical protein -
  P2T63_RS10655 (P2T63_10655) - 2154976..2155104 (-) 129 WP_004049941.1 hypothetical protein -
  P2T63_RS10660 (P2T63_10660) - 2155118..2155255 (-) 138 WP_004049939.1 hypothetical protein -
  P2T63_RS10665 (P2T63_10665) - 2155239..2155478 (-) 240 WP_119448610.1 hypothetical protein -
  P2T63_RS10670 (P2T63_10670) - 2155670..2155798 (-) 129 WP_257586936.1 hypothetical protein -
  P2T63_RS10675 (P2T63_10675) - 2155931..2157157 (-) 1227 WP_089135228.1 aminotransferase class III-fold pyridoxal phosphate-dependent enzyme -
  P2T63_RS10680 (P2T63_10680) - 2157173..2157889 (-) 717 Protein_2067 hypothetical protein -
  P2T63_RS10685 (P2T63_10685) - 2157962..2159134 (+) 1173 WP_004047661.1 IS256 family transposase -
  P2T63_RS10690 (P2T63_10690) - 2159187..2159453 (-) 267 Protein_2069 SDR family NAD(P)-dependent oxidoreductase -
  P2T63_RS10695 (P2T63_10695) - 2159446..2160183 (-) 738 WP_004049933.1 methyltransferase domain-containing protein -
  P2T63_RS10700 (P2T63_10700) - 2160176..2161324 (-) 1149 WP_004049932.1 hypothetical protein -
  P2T63_RS10705 (P2T63_10705) - 2161499..2162671 (-) 1173 WP_004047661.1 IS256 family transposase -
  P2T63_RS10710 (P2T63_10710) - 2162786..2163184 (-) 399 Protein_2073 ABC transporter permease -
  P2T63_RS10715 (P2T63_10715) - 2163177..2164022 (-) 846 WP_004049928.1 ABC transporter ATP-binding protein -
  P2T63_RS10720 (P2T63_10720) - 2164546..2165871 (-) 1326 WP_179936073.1 sensor histidine kinase -
  P2T63_RS10725 (P2T63_10725) comE/blpR 2165886..2166623 (-) 738 WP_004049924.1 response regulator transcription factor Regulator

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28239.61 Da        Isoelectric Point: 5.9838

>NTDB_id=805160 P2T63_RS10725 WP_004049924.1 2165886..2166623(-) (comE/blpR) [Ligilactobacillus murinus strain PG1-1-10]
MINIFVLEDEILQQSRIETAILKILNEEQIKCRVFDVFGSSSQLLEAIEERGGHQLFFLDIEIKDEEKKGLEIAKEIRKK
DPAATIVFVTTHSEFMPLTFKFKVSALDFIDKALGEQYFYERIKSAIDYTLASAGETLSQESFHLETSLSQIQVPLKKIL
YFETSPTVHKVILHTIDERIEFYATISEIEKKDSRLYRSHKSFVVNPANIERLDKVNKIIYFPNGDSCLVARTKLKGLSE
RITLL

Nucleotide


Download         Length: 738 bp        

>NTDB_id=805160 P2T63_RS10725 WP_004049924.1 2165886..2166623(-) (comE/blpR) [Ligilactobacillus murinus strain PG1-1-10]
ATGATCAATATTTTTGTACTTGAAGATGAGATACTTCAACAGTCTCGCATTGAAACGGCCATTCTAAAAATTTTAAACGA
AGAACAGATAAAGTGTAGAGTTTTTGATGTTTTTGGAAGCTCTTCTCAATTGTTAGAAGCTATTGAGGAGAGAGGGGGGC
ACCAGTTATTTTTCCTAGATATTGAAATTAAGGACGAGGAGAAAAAAGGACTGGAGATCGCTAAGGAGATCCGAAAAAAA
GATCCCGCTGCGACTATCGTTTTTGTGACGACGCATTCGGAATTTATGCCACTAACATTTAAATTTAAAGTTAGTGCTCT
TGATTTTATCGATAAAGCTTTAGGAGAGCAATACTTCTATGAGCGTATTAAATCTGCTATTGACTACACACTAGCTAGTG
CTGGAGAAACGCTGTCTCAAGAATCATTTCATTTAGAAACGTCACTATCTCAAATACAAGTGCCTTTAAAAAAAATCCTG
TATTTTGAAACATCCCCGACTGTACATAAGGTTATTTTGCATACGATCGATGAACGAATTGAATTTTATGCAACGATCTC
TGAGATCGAAAAAAAAGACAGCCGATTATATAGAAGCCATAAGTCATTTGTAGTAAATCCTGCTAACATTGAGCGTCTGG
ATAAGGTCAATAAGATCATTTATTTTCCAAATGGAGATTCTTGTTTAGTAGCACGAACAAAACTTAAAGGATTAAGTGAA
AGGATTACATTATTGTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-123)

LytTr DNA-binding domain (LytTR)

(152-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

55.23

97.551

0.539
  comE/comE1 Streptococcus equinus JB1

47.521

98.776

0.469
  comE/comE2 Streptococcus equinus JB1

41.736

98.776

0.412
  comE/comE2 Streptococcus gordonii strain NCTC7865

39.754

99.592

0.396
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

39.754

99.592

0.396
  comE Streptococcus pneumoniae R6

37.037

99.184

0.367
  comE Streptococcus pneumoniae TIGR4

37.037

99.184

0.367
  comE Streptococcus mitis NCTC 12261

37.037

99.184

0.367
  comE Streptococcus mitis SK321

37.037

99.184

0.367
  comE Streptococcus pneumoniae Rx1

37.037

99.184

0.367
  comE Streptococcus pneumoniae D39

37.037

99.184

0.367
  comE Streptococcus infantis strain Atu-4

36.626

99.184

0.363