Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   PW252_RS10690 Genome accession   NZ_CP118735
Coordinates   2207904..2208641 (-) Length   245 a.a.
NCBI ID   WP_248049227.1    Uniprot ID   A0AA97A3M5
Organism   Streptococcus iners strain 29887     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 2202904..2213641
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PW252_RS10655 (PW252_10655) - 2203082..2203324 (-) 243 WP_248049232.1 hypothetical protein -
  PW252_RS10660 (PW252_10660) - 2203346..2204035 (-) 690 WP_248049231.1 CPBP family intramembrane glutamic endopeptidase -
  PW252_RS10665 (PW252_10665) - 2204158..2204340 (-) 183 WP_248049230.1 hypothetical protein -
  PW252_RS10670 (PW252_10670) - 2204366..2204527 (-) 162 WP_172085984.1 hypothetical protein -
  PW252_RS10675 (PW252_10675) - 2205649..2206020 (-) 372 WP_248049229.1 hypothetical protein -
  PW252_RS10680 (PW252_10680) - 2206053..2206226 (-) 174 WP_153603712.1 hypothetical protein -
  PW252_RS10685 (PW252_10685) - 2206564..2207904 (-) 1341 WP_248049228.1 sensor histidine kinase -
  PW252_RS10690 (PW252_10690) comE/blpR 2207904..2208641 (-) 738 WP_248049227.1 response regulator transcription factor Regulator
  PW252_RS10695 (PW252_10695) - 2208858..2208959 (-) 102 WP_153052760.1 putative holin-like toxin -
  PW252_RS10700 (PW252_10700) - 2209393..2209536 (-) 144 WP_248049226.1 putative holin-like toxin -
  PW252_RS10705 (PW252_10705) - 2209649..2209834 (-) 186 WP_248049225.1 hypothetical protein -
  PW252_RS10710 (PW252_10710) dtd 2209896..2210339 (-) 444 WP_105118646.1 D-aminoacyl-tRNA deacylase -
  PW252_RS10715 (PW252_10715) - 2210341..2212542 (-) 2202 WP_105125048.1 RelA/SpoT family protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28395.28 Da        Isoelectric Point: 5.3973

>NTDB_id=794758 PW252_RS10690 WP_248049227.1 2207904..2208641(-) (comE/blpR) [Streptococcus iners strain 29887]
MLNIFVLEDDFFQQSRLENAIRRCVEETSVRYKFLEVFGKPNQLLESIEEAGNHQFFFLDIEIKGEEKKGMEIAKEIRAR
DPYAVIVFVTTHSEFMPVTYRYRVSALDFIDKGLEDSDFQKAVSDVLVHAFENIDHTIAENSFIYKTETAHIQVPFSDIL
YFETSSTIHKVILKTKTGQTEFYGKVSDIAKADERLYQAHRSCVVNPLNITKLDRVNHIAYFDNGDSCFVSRLKQKKLAD
LLEIN

Nucleotide


Download         Length: 738 bp        

>NTDB_id=794758 PW252_RS10690 WP_248049227.1 2207904..2208641(-) (comE/blpR) [Streptococcus iners strain 29887]
ATGCTTAATATTTTTGTATTAGAAGATGATTTTTTTCAGCAGAGTAGGCTAGAAAATGCTATTAGGCGGTGTGTTGAAGA
AACGTCAGTAAGGTATAAATTCCTAGAAGTTTTTGGTAAACCAAATCAGTTATTGGAATCAATTGAGGAAGCAGGCAATC
ACCAATTTTTCTTTTTAGATATTGAAATTAAAGGCGAAGAAAAGAAAGGAATGGAAATCGCTAAAGAAATCCGTGCTCGA
GATCCTTATGCTGTTATTGTCTTTGTAACAACTCACTCAGAATTTATGCCGGTAACGTATCGTTATCGGGTTTCTGCTTT
AGATTTTATAGATAAAGGCCTGGAGGATAGTGACTTTCAAAAGGCAGTATCAGATGTGTTAGTGCATGCTTTTGAAAATA
TTGATCATACTATAGCTGAAAATTCTTTTATATACAAAACTGAAACTGCTCATATTCAAGTCCCTTTTAGTGACATCCTT
TATTTTGAAACATCATCAACGATTCATAAAGTCATTTTAAAAACGAAAACAGGTCAGACTGAGTTTTACGGGAAAGTATC
CGATATAGCGAAAGCTGACGAACGACTTTACCAGGCACATCGTTCTTGTGTAGTGAATCCATTAAATATAACGAAGTTGG
ACAGAGTAAACCATATTGCCTATTTTGATAATGGAGATTCTTGTTTTGTTTCTCGTTTGAAGCAGAAGAAACTTGCAGAT
TTGTTGGAGATTAATTGA

Domains

Predicted by InterProScan.

LytTr DNA-binding domain (LytTR)

(152-242)

Response regulator receiver domain (Response_reg)

(4-123)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

55.649

97.551

0.543
  comE/comE1 Streptococcus equinus JB1

49.58

97.143

0.482
  comE/comE2 Streptococcus equinus JB1

41.152

99.184

0.408
  comE Streptococcus pneumoniae TIGR4

38.554

100

0.392
  comE Streptococcus pneumoniae D39

38.554

100

0.392
  comE Streptococcus pneumoniae R6

38.554

100

0.392
  comE Streptococcus infantis strain Atu-4

38.554

100

0.392
  comE Streptococcus mitis NCTC 12261

38.554

100

0.392
  comE Streptococcus mitis SK321

38.554

100

0.392
  comE Streptococcus pneumoniae Rx1

38.554

100

0.392
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

38.618

100

0.388
  comE/comE2 Streptococcus gordonii strain NCTC7865

38.618

100

0.388