Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   PW252_RS10690 Genome accession   NZ_CP118735
Coordinates   2207904..2208641 (-) Length   245 a.a.
NCBI ID   WP_248049227.1    Uniprot ID   A0AA97A3M5
Organism   Streptococcus iners strain 29887     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 2196729..2226321 2207904..2208641 within 0


Gene organization within MGE regions


Location: 2196729..2226321
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PW252_RS10600 (PW252_10600) - 2196729..2197169 (+) 441 WP_248049244.1 hypothetical protein -
  PW252_RS10605 (PW252_10605) - 2197251..2197760 (+) 510 WP_248049242.1 hypothetical protein -
  PW252_RS10610 (PW252_10610) - 2197768..2198286 (+) 519 WP_248032986.1 hypothetical protein -
  PW252_RS10615 (PW252_10615) - 2198394..2198669 (-) 276 WP_248049240.1 hypothetical protein -
  PW252_RS10620 (PW252_10620) - 2198767..2199264 (-) 498 WP_248049239.1 CPBP family intramembrane glutamic endopeptidase -
  PW252_RS10625 (PW252_10625) - 2199757..2200176 (-) 420 WP_136647942.1 hypothetical protein -
  PW252_RS10630 (PW252_10630) - 2200236..2200886 (-) 651 WP_248049235.1 CPBP family intramembrane glutamic endopeptidase -
  PW252_RS10635 (PW252_10635) - 2201112..2201399 (+) 288 WP_029185759.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  PW252_RS10640 (PW252_10640) - 2201389..2201730 (+) 342 WP_024398777.1 type II toxin-antitoxin system RelE/ParE family toxin -
  PW252_RS10645 (PW252_10645) - 2202161..2202355 (-) 195 WP_172021762.1 hypothetical protein -
  PW252_RS10650 (PW252_10650) - 2202377..2203078 (-) 702 WP_248049233.1 CPBP family intramembrane glutamic endopeptidase -
  PW252_RS10655 (PW252_10655) - 2203082..2203324 (-) 243 WP_248049232.1 hypothetical protein -
  PW252_RS10660 (PW252_10660) - 2203346..2204035 (-) 690 WP_248049231.1 CPBP family intramembrane glutamic endopeptidase -
  PW252_RS10665 (PW252_10665) - 2204158..2204340 (-) 183 WP_248049230.1 hypothetical protein -
  PW252_RS10670 (PW252_10670) - 2204366..2204527 (-) 162 WP_172085984.1 hypothetical protein -
  PW252_RS10675 (PW252_10675) - 2205649..2206020 (-) 372 WP_248049229.1 hypothetical protein -
  PW252_RS10680 (PW252_10680) - 2206053..2206226 (-) 174 WP_153603712.1 hypothetical protein -
  PW252_RS10685 (PW252_10685) - 2206564..2207904 (-) 1341 WP_248049228.1 sensor histidine kinase -
  PW252_RS10690 (PW252_10690) comE/blpR 2207904..2208641 (-) 738 WP_248049227.1 response regulator transcription factor Regulator
  PW252_RS10695 (PW252_10695) - 2208858..2208959 (-) 102 WP_153052760.1 putative holin-like toxin -
  PW252_RS10700 (PW252_10700) - 2209393..2209536 (-) 144 WP_248049226.1 putative holin-like toxin -
  PW252_RS10705 (PW252_10705) - 2209649..2209834 (-) 186 WP_248049225.1 hypothetical protein -
  PW252_RS10710 (PW252_10710) dtd 2209896..2210339 (-) 444 WP_105118646.1 D-aminoacyl-tRNA deacylase -
  PW252_RS10715 (PW252_10715) - 2210341..2212542 (-) 2202 WP_105125048.1 RelA/SpoT family protein -
  PW252_RS10720 (PW252_10720) - 2212807..2215335 (+) 2529 WP_248049224.1 bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase -
  PW252_RS10725 (PW252_10725) - 2215358..2215879 (+) 522 WP_248049223.1 GNAT family N-acetyltransferase -
  PW252_RS10730 (PW252_10730) - 2215906..2216622 (-) 717 WP_248049222.1 DUF554 domain-containing protein -
  PW252_RS10735 (PW252_10735) - 2216626..2217372 (-) 747 WP_248049221.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
  PW252_RS10740 (PW252_10740) prmA 2217374..2218327 (-) 954 WP_248049220.1 50S ribosomal protein L11 methyltransferase -
  PW252_RS10745 (PW252_10745) - 2218481..2219566 (-) 1086 WP_248049219.1 hypothetical protein -
  PW252_RS10750 (PW252_10750) - 2219553..2221043 (-) 1491 WP_248049218.1 AAA family ATPase -
  PW252_RS10755 (PW252_10755) - 2221050..2221520 (-) 471 WP_024387820.1 DUF3013 family protein -
  PW252_RS10760 (PW252_10760) - 2221632..2221961 (-) 330 WP_248049217.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
  PW252_RS10765 (PW252_10765) - 2222031..2223314 (+) 1284 WP_248049216.1 replication-associated recombination protein A -
  PW252_RS10780 (PW252_10780) nrdG 2223758..2224330 (-) 573 WP_248049215.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  PW252_RS10785 (PW252_10785) - 2224346..2224837 (-) 492 WP_248049214.1 GNAT family N-acetyltransferase -
  PW252_RS10790 (PW252_10790) - 2224839..2226185 (-) 1347 WP_248049213.1 bifunctional metallophosphatase/5'-nucleotidase -
  PW252_RS10795 (PW252_10795) - 2226187..2226321 (-) 135 WP_014638808.1 hypothetical protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28395.28 Da        Isoelectric Point: 5.3973

>NTDB_id=794758 PW252_RS10690 WP_248049227.1 2207904..2208641(-) (comE/blpR) [Streptococcus iners strain 29887]
MLNIFVLEDDFFQQSRLENAIRRCVEETSVRYKFLEVFGKPNQLLESIEEAGNHQFFFLDIEIKGEEKKGMEIAKEIRAR
DPYAVIVFVTTHSEFMPVTYRYRVSALDFIDKGLEDSDFQKAVSDVLVHAFENIDHTIAENSFIYKTETAHIQVPFSDIL
YFETSSTIHKVILKTKTGQTEFYGKVSDIAKADERLYQAHRSCVVNPLNITKLDRVNHIAYFDNGDSCFVSRLKQKKLAD
LLEIN

Nucleotide


Download         Length: 738 bp        

>NTDB_id=794758 PW252_RS10690 WP_248049227.1 2207904..2208641(-) (comE/blpR) [Streptococcus iners strain 29887]
ATGCTTAATATTTTTGTATTAGAAGATGATTTTTTTCAGCAGAGTAGGCTAGAAAATGCTATTAGGCGGTGTGTTGAAGA
AACGTCAGTAAGGTATAAATTCCTAGAAGTTTTTGGTAAACCAAATCAGTTATTGGAATCAATTGAGGAAGCAGGCAATC
ACCAATTTTTCTTTTTAGATATTGAAATTAAAGGCGAAGAAAAGAAAGGAATGGAAATCGCTAAAGAAATCCGTGCTCGA
GATCCTTATGCTGTTATTGTCTTTGTAACAACTCACTCAGAATTTATGCCGGTAACGTATCGTTATCGGGTTTCTGCTTT
AGATTTTATAGATAAAGGCCTGGAGGATAGTGACTTTCAAAAGGCAGTATCAGATGTGTTAGTGCATGCTTTTGAAAATA
TTGATCATACTATAGCTGAAAATTCTTTTATATACAAAACTGAAACTGCTCATATTCAAGTCCCTTTTAGTGACATCCTT
TATTTTGAAACATCATCAACGATTCATAAAGTCATTTTAAAAACGAAAACAGGTCAGACTGAGTTTTACGGGAAAGTATC
CGATATAGCGAAAGCTGACGAACGACTTTACCAGGCACATCGTTCTTGTGTAGTGAATCCATTAAATATAACGAAGTTGG
ACAGAGTAAACCATATTGCCTATTTTGATAATGGAGATTCTTGTTTTGTTTCTCGTTTGAAGCAGAAGAAACTTGCAGAT
TTGTTGGAGATTAATTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(152-242)

Response regulator receiver domain (Response_reg)

(4-123)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

55.649

97.551

0.543
  comE/comE1 Streptococcus equinus JB1

49.58

97.143

0.482
  comE/comE2 Streptococcus equinus JB1

41.152

99.184

0.408
  comE Streptococcus pneumoniae TIGR4

38.554

100

0.392
  comE Streptococcus pneumoniae D39

38.554

100

0.392
  comE Streptococcus pneumoniae R6

38.554

100

0.392
  comE Streptococcus infantis strain Atu-4

38.554

100

0.392
  comE Streptococcus mitis NCTC 12261

38.554

100

0.392
  comE Streptococcus mitis SK321

38.554

100

0.392
  comE Streptococcus pneumoniae Rx1

38.554

100

0.392
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

38.618

100

0.388
  comE/comE2 Streptococcus gordonii strain NCTC7865

38.618

100

0.388