Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   PHA78_RS11955 Genome accession   NZ_CP116604
Coordinates   2426581..2427339 (-) Length   252 a.a.
NCBI ID   WP_272158238.1    Uniprot ID   -
Organism   Streptococcus sp. HN38     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 2424433..2446152 2426581..2427339 within 0


Gene organization within MGE regions


Location: 2424433..2446152
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PHA78_RS11945 - 2424433..2425047 (-) 615 WP_099806874.1 PBECR4 domain-containing protein -
  PHA78_RS11950 - 2425272..2426603 (-) 1332 WP_024409704.1 GHKL domain-containing protein -
  PHA78_RS11955 comE/blpR 2426581..2427339 (-) 759 WP_272158238.1 response regulator transcription factor Regulator
  PHA78_RS11965 - 2428201..2428386 (-) 186 WP_024379357.1 hypothetical protein -
  PHA78_RS11970 dtd 2428449..2428892 (-) 444 WP_272158240.1 D-aminoacyl-tRNA deacylase -
  PHA78_RS11975 - 2428894..2431095 (-) 2202 WP_002941987.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
  PHA78_RS11980 - 2431352..2433835 (+) 2484 WP_272158243.1 bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase -
  PHA78_RS11985 - 2433884..2434598 (-) 715 Protein_2331 DUF554 domain-containing protein -
  PHA78_RS11990 - 2434603..2435349 (-) 747 WP_024376191.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
  PHA78_RS11995 prmA 2435351..2436304 (-) 954 WP_024376192.1 50S ribosomal protein L11 methyltransferase -
  PHA78_RS12000 - 2436336..2437235 (-) 900 WP_029175435.1 GIY-YIG nuclease family protein -
  PHA78_RS12005 - 2437248..2437718 (-) 471 WP_099872482.1 DUF3013 family protein -
  PHA78_RS12010 - 2437830..2438159 (-) 330 WP_099871045.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
  PHA78_RS12015 - 2438228..2439511 (+) 1284 WP_272158251.1 replication-associated recombination protein A -
  PHA78_RS12030 nrdG 2439953..2440525 (-) 573 WP_272158254.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  PHA78_RS12035 - 2440541..2441032 (-) 492 WP_024377588.1 GNAT family N-acetyltransferase -
  PHA78_RS12040 - 2441034..2441240 (-) 207 WP_099806945.1 5'-nucleotidase C-terminal domain-containing protein -
  PHA78_RS12045 - 2441391..2441525 (-) 135 WP_032500125.1 hypothetical protein -
  PHA78_RS12050 nrdD 2441617..2443788 (-) 2172 WP_099806944.1 anaerobic ribonucleoside-triphosphate reductase -
  PHA78_RS12055 - 2443932..2444105 (-) 174 WP_002941962.1 hypothetical protein -
  PHA78_RS12060 - 2444139..2444579 (-) 441 WP_024377585.1 DUF3021 domain-containing protein -
  PHA78_RS12065 - 2444576..2445019 (-) 444 WP_024376203.1 LytTR family DNA-binding domain-containing protein -
  PHA78_RS12070 - 2445188..2445589 (-) 402 WP_099806943.1 hypothetical protein -
  PHA78_RS12075 - 2445604..2446152 (-) 549 WP_024376205.1 hypothetical protein -

Sequence

Protein


Download         Length: 252 a.a.        Molecular weight: 29275.17 Da        Isoelectric Point: 5.4072

>NTDB_id=778791 PHA78_RS11955 WP_272158238.1 2426581..2427339(-) (comE/blpR) [Streptococcus sp. HN38]
MLNIFVLEDDFFQQSRLENAIRRCVEETSVRYKFLEVFGKPNQLLDSIEEAGNHQFFFLDIEIKGEEKKGMEIAKEIRAR
DPYAVIVFVTTHSEFMPVTYRYRVSALDFIDKGLEDSDFQKAVSDVLVHAFENIDHTIAENSFVYKTETAHIQVPFSDIL
YFETSSTIHKVILKTKTGQTEFYGKVSDISKADERLYQAHRSCVVNPLNITRLDRTNHIAYFENGDSCFVSRLKQGKLVE
LVEKNNDYLTRI

Nucleotide


Download         Length: 759 bp        

>NTDB_id=778791 PHA78_RS11955 WP_272158238.1 2426581..2427339(-) (comE/blpR) [Streptococcus sp. HN38]
ATGCTTAATATTTTTGTATTAGAAGATGATTTTTTTCAGCAGAGTAGGCTAGAAAATGCTATTAGACGGTGTGTTGAAGA
AACGTCAGTAAGGTATAAATTCCTAGAAGTTTTTGGTAAACCAAATCAATTATTGGACTCAATTGAGGAAGCAGGCAATC
ACCAATTTTTCTTTTTAGATATTGAAATTAAAGGCGAAGAAAAGAAAGGAATGGAAATCGCTAAAGAAATCCGTGCTCGA
GATCCTTATGCCGTTATTGTCTTTGTAACGACACACTCAGAATTTATGCCGGTAACGTATCGTTATCGAGTCTCTGCTTT
AGATTTTATAGATAAAGGCCTAGAGGATAGTGACTTTCAAAAGGCAGTATCAGATGTGTTAGTGCATGCTTTTGAAAATA
TTGATCATACTATAGCTGAAAATTCTTTTGTATACAAAACTGAAACTGCTCATATTCAAGTCCCTTTTAGTGATATTCTT
TATTTTGAAACATCATCAACGATTCATAAAGTCATTTTAAAAACCAAAACAGGTCAGACTGAGTTTTACGGGAAAGTATC
CGATATATCGAAAGCAGATGAACGACTTTACCAGGCACATCGTTCTTGTGTAGTGAATCCATTAAATATAACGAGATTGG
ACAGAACAAACCATATTGCCTATTTTGAGAATGGAGATTCTTGTTTTGTTTCCAGATTAAAACAAGGGAAATTGGTAGAA
CTAGTGGAGAAAAACAATGACTATCTCACCAGGATATGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(152-241)

Response regulator receiver domain (Response_reg)

(4-123)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

55.144

96.429

0.532
  comE/comE1 Streptococcus equinus JB1

48.954

94.841

0.464
  comE/comE2 Streptococcus equinus JB1

42.241

92.063

0.389
  comE Streptococcus infantis strain Atu-4

37.302

100

0.373
  comE Streptococcus pneumoniae TIGR4

37.6

99.206

0.373
  comE Streptococcus pneumoniae D39

37.6

99.206

0.373
  comE Streptococcus pneumoniae R6

37.6

99.206

0.373
  comE Streptococcus mitis SK321

37.6

99.206

0.373
  comE Streptococcus mitis NCTC 12261

37.6

99.206

0.373
  comE Streptococcus pneumoniae Rx1

37.6

99.206

0.373
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

38.211

97.619

0.373
  comE/comE2 Streptococcus gordonii strain NCTC7865

38.211

97.619

0.373