Detailed information NTG0761526

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: OTB22_RS10870
• Genome accession: NZ_CP113267
• Coordinates: 2123210..2123962 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain BC2
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2118210..2128962

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OTB22_RS10840 (OTB22_10845)	-	2118559..2121111 (+)	2553	WP_000834682.1	YfhO family protein	-
OTB22_RS11130	-	2121141..2122318 (-)	1178	Protein_2106	YhgE/Pip family protein	-
OTB22_RS10855 (OTB22_10860)	-	2122425..2122967 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
OTB22_RS10870 (OTB22_10875)	comE	2123210..2123962 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
OTB22_RS10875 (OTB22_10880)	comD/comD1	2123959..2125284 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
OTB22_RS10880 (OTB22_10885)	comC/comC1	2125305..2125430 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
OTB22_RS10890 (OTB22_10895)	rlmH	2125712..2126191 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
OTB22_RS10895 (OTB22_10900)	htrA	2126374..2127555 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
OTB22_RS10900 (OTB22_10905)	spo0J	2127613..2128371 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=761526 OTB22_RS10870 WP_000866065.1 2123210..2123962(-) (comE) [Streptococcus pneumoniae strain BC2]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=761526 OTB22_RS10870 WP_000866065.1 2123210..2123962(-) (comE) [Streptococcus pneumoniae strain BC2]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATATCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408