Detailed information NTG0727335

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: N2A94_RS01015
• Genome accession: NZ_CP104048
• Coordinates: 200364..201101 (+)
• Length: 245 a.a.
• NCBI ID: WP_003107762.1
• Uniprot ID: A0A0E2UAG5
• Organism: Streptococcus parauberis strain KSP20
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 195364..206101

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
N2A94_RS00995 (N2A94_00995)	-	195498..196010 (+)	513	WP_238570146.1	hypothetical protein	-
N2A94_RS01000 (N2A94_01000)	-	196220..197539 (+)	1320	WP_003107766.1	GHKL domain-containing protein	-
N2A94_RS01005 (N2A94_01005)	-	197704..199050 (+)	1347	WP_037620084.1	GHKL domain-containing protein	-
N2A94_RS01010 (N2A94_01010)	-	199345..200361 (+)	1017	WP_231082314.1	GHKL domain-containing protein	-
N2A94_RS01015 (N2A94_01015)	comE/blpR	200364..201101 (+)	738	WP_003107762.1	LytTR family DNA-binding domain-containing protein	Regulator
N2A94_RS01020 (N2A94_01020)	-	201595..202797 (+)	1203	WP_013794463.1	argininosuccinate synthase	-
N2A94_RS01025 (N2A94_01025)	argH	202837..204222 (+)	1386	WP_003107760.1	argininosuccinate lyase	-
N2A94_RS01030 (N2A94_01030)	-	204358..205455 (-)	1098	WP_259966578.1	site-specific integrase	-
N2A94_RS01035 (N2A94_01035)	-	205618..205917 (-)	300	WP_259966524.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28923.23 Da
• Isoelectric Point: 4.7047

>NTDB_id=727335 N2A94_RS01015 WP_003107762.1 200364..201101(+) (comE/blpR) [Streptococcus parauberis strain KSP20]
MNIFILEDDFIQQTRIESAIESILKENNISCKFMEVFSNPQKLYDAILEKGDHQIFFLDIEIQGESRKGLELATEIRQKD
PNAVIVFVTTHSEFAPISYKYKVSALDFIDKSVDTKQFKEQIQECIFYTNEMMSKNEPEDLFIFETPQTRLKMPLKDILY
FATSTTPHKVCLWTQTERLEFYGKLSEIQEVAPELFLCHRSYLINLDNVVRIDKFNQLVYFENGDDVMVSRLKMKSLIEK
WQELH

Nucleotide

• Length: 738 bp

>NTDB_id=727335 N2A94_RS01015 WP_003107762.1 200364..201101(+) (comE/blpR) [Streptococcus parauberis strain KSP20]
ATGAACATTTTTATATTAGAAGATGATTTTATCCAGCAAACTCGAATAGAATCAGCAATTGAAAGTATCCTCAAAGAAAA
TAATATAAGCTGCAAATTTATGGAAGTTTTTTCAAATCCCCAAAAGCTGTATGATGCCATCCTAGAAAAAGGTGACCATC
AGATTTTTTTCCTTGATATCGAAATTCAAGGAGAATCACGCAAGGGCTTGGAATTAGCAACTGAAATTCGTCAAAAAGAT
CCAAATGCAGTTATTGTTTTTGTGACGACTCATTCAGAGTTTGCTCCAATTTCCTATAAATATAAAGTGTCAGCACTTGA
TTTTATTGATAAGTCGGTTGATACTAAGCAATTTAAGGAACAAATACAAGAATGTATTTTTTACACGAATGAGATGATGT
CAAAAAACGAACCAGAAGATCTCTTTATTTTTGAGACACCTCAAACTAGACTAAAAATGCCACTAAAGGATATCCTTTAC
TTTGCAACTTCAACAACACCCCATAAAGTTTGTTTGTGGACACAAACAGAACGACTCGAGTTTTATGGTAAATTATCTGA
AATTCAAGAAGTAGCACCAGAGTTATTTCTCTGTCACCGTTCTTACTTGATTAATCTTGATAATGTTGTTCGAATTGATA
AATTTAATCAATTAGTCTATTTTGAAAATGGTGATGATGTTATGGTCTCACGACTCAAAATGAAAAGTTTAATTGAAAAA
TGGCAAGAATTACACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A0E2UAG5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	51.681	97.143	0.502
comE/comE2	Streptococcus equinus JB1	43.033	99.592	0.429
comE/comE1	Streptococcus equinus JB1	42.857	97.143	0.416
comE/comE2	Streptococcus gordonii strain NCTC7865	39.918	99.184	0.396
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.918	99.184	0.396
comE	Streptococcus pneumoniae D39	37.603	98.776	0.371
comE	Streptococcus pneumoniae Rx1	37.603	98.776	0.371
comE	Streptococcus pneumoniae R6	37.603	98.776	0.371
comE	Streptococcus pneumoniae TIGR4	37.603	98.776	0.371
comE	Streptococcus mitis NCTC 12261	37.759	98.367	0.371
comE	Streptococcus mitis SK321	37.759	98.367	0.371
comE	Streptococcus infantis strain Atu-4	36.777	98.776	0.363