Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   NWE22_RS00505 Genome accession   NZ_CP102747
Coordinates   88552..89289 (+) Length   245 a.a.
NCBI ID   WP_277745489.1    Uniprot ID   -
Organism   Streptococcus parasuis strain SFJ45     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 83552..94289
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NWE22_RS00490 (NWE22_00490) - 84134..84670 (-) 537 WP_216806237.1 GNAT family N-acetyltransferase -
  NWE22_RS00495 (NWE22_00495) - 84781..86985 (+) 2205 WP_239604424.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
  NWE22_RS00500 (NWE22_00500) dtd 86987..87430 (+) 444 WP_130554438.1 D-aminoacyl-tRNA deacylase -
  NWE22_RS10305 - 87507..87692 (+) 186 WP_024391547.1 hypothetical protein -
  NWE22_RS00505 (NWE22_00505) comE/blpR 88552..89289 (+) 738 WP_277745489.1 response regulator transcription factor Regulator
  NWE22_RS00510 (NWE22_00510) - 89286..90632 (+) 1347 WP_239604426.1 GHKL domain-containing protein -
  NWE22_RS00515 (NWE22_00515) - 91088..91876 (+) 789 WP_239604427.1 ParA family protein -
  NWE22_RS00520 (NWE22_00520) - 91889..92113 (+) 225 WP_024379520.1 hypothetical protein -
  NWE22_RS00525 (NWE22_00525) - 92359..92502 (+) 144 WP_153594002.1 bacteriocin -
  NWE22_RS00530 (NWE22_00530) - 92513..92638 (+) 126 WP_105129977.1 bacteriocin -
  NWE22_RS00535 (NWE22_00535) - 92817..93005 (+) 189 WP_029176448.1 hypothetical protein -
  NWE22_RS00540 (NWE22_00540) - 93026..93217 (+) 192 WP_029176447.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  NWE22_RS00545 (NWE22_00545) - 93245..93454 (+) 210 WP_172089147.1 hypothetical protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28527.49 Da        Isoelectric Point: 5.6568

>NTDB_id=718676 NWE22_RS00505 WP_277745489.1 88552..89289(+) (comE/blpR) [Streptococcus parasuis strain SFJ45]
MLNIFVLEDDFFQQSRLENAIRRCVEETSVRYKFLEVFGKPNQLLESIEEAGNHQFFFLDIEIKGEEKKGMEIAKEIRAR
DPYAVIVFVTTHSEFMPVTYRYRVSALDFIDKGLEDSDFQKAVSDVLVHAFENIDHTIAENSFVYKTETAYIQVPFSDIL
YFETSSTIHKVILKTKTGQTEFYGKVSDIAKAYERLYQAHRSCVVNPLNITRLDRTNHIAYFENGESCFVSRLKQKKLAD
LLEIK

Nucleotide


Download         Length: 738 bp        

>NTDB_id=718676 NWE22_RS00505 WP_277745489.1 88552..89289(+) (comE/blpR) [Streptococcus parasuis strain SFJ45]
ATGCTTAATATTTTTGTATTAGAAGATGATTTTTTTCAGCAGAGCAGGCTAGAAAATGCTATTAGGCGGTGTGTTGAAGA
AACGTCAGTAAGGTATAAATTCCTAGAAGTTTTTGGTAAACCAAATCAGTTATTGGAATCAATTGAGGAAGCAGGCAATC
ACCAATTTTTCTTTTTAGATATTGAAATTAAAGGCGAAGAAAAGAAAGGAATGGAAATCGCTAAAGAAATCCGTGCTCGC
GATCCCTATGCTGTTATTGTCTTTGTAACAACTCACTCAGAATTTATGCCGGTAACGTATCGTTATCGAGTTTCTGCTTT
AGATTTTATAGATAAAGGCCTAGAGGATAGTGACTTTCAAAAGGCAGTATCAGATGTGTTAGTGCATGCTTTTGAAAATA
TTGATCATACTATAGCTGAAAATTCTTTTGTATATAAAACTGAAACTGCTTATATTCAAGTCCCTTTTAGTGATATTCTT
TATTTTGAAACATCATCAACGATTCATAAAGTCATTTTAAAAACGAAAACAGGTCAGACTGAGTTTTACGGGAAAGTATC
CGATATAGCGAAAGCTTACGAACGACTTTACCAGGCACATCGTTCTTGTGTAGTGAATCCATTAAATATAACAAGATTGG
ACAGAACAAACCATATTGCCTATTTTGAGAATGGAGAATCTTGTTTTGTTTCTCGTTTGAAGCAGAAGAAACTTGCAGAT
TTGCTGGAGATTAAATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-123)

LytTr DNA-binding domain (LytTR)

(151-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

55.23

97.551

0.539
  comE/comE1 Streptococcus equinus JB1

49.58

97.143

0.482
  comE/comE2 Streptococcus equinus JB1

41.564

99.184

0.412
  comE Streptococcus mitis SK321

38.645

100

0.396
  comE Streptococcus infantis strain Atu-4

38.645

100

0.396
  comE Streptococcus pneumoniae R6

38.645

100

0.396
  comE Streptococcus pneumoniae TIGR4

38.645

100

0.396
  comE Streptococcus mitis NCTC 12261

38.645

100

0.396
  comE Streptococcus pneumoniae Rx1

38.645

100

0.396
  comE Streptococcus pneumoniae D39

38.645

100

0.396
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

38.306

100

0.388
  comE/comE2 Streptococcus gordonii strain NCTC7865

38.306

100

0.388