Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   FGCSD_RS08060 Genome accession   NZ_AP018726
Coordinates   1616571..1617320 (+) Length   249 a.a.
NCBI ID   WP_129556053.1    Uniprot ID   -
Organism   Streptococcus dysgalactiae strain Kdys0611     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1601679..1648487 1616571..1617320 within 0
IScluster/Tn 1614170..1622483 1616571..1617320 within 0


Gene organization within MGE regions


Location: 1601679..1648487
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGCSD_RS07990 (FGCSD_1554) - 1601679..1602863 (+) 1185 WP_012766664.1 DNA/RNA non-specific endonuclease -
  FGCSD_RS07995 (FGCSD_1555) - 1603000..1603926 (+) 927 WP_129556047.1 glycosyltransferase family 2 protein -
  FGCSD_RS11295 - 1606650..1606847 (-) 198 WP_232022237.1 hypothetical protein -
  FGCSD_RS08015 (FGCSD_1561) smpB 1607179..1607646 (-) 468 WP_129556050.1 SsrA-binding protein SmpB -
  FGCSD_RS08020 (FGCSD_1562) rnr 1607649..1609979 (-) 2331 WP_172595997.1 ribonuclease R -
  FGCSD_RS08025 (FGCSD_1563) secG 1610076..1610312 (-) 237 WP_003047129.1 preprotein translocase subunit SecG -
  FGCSD_RS08030 rpmG 1610358..1610504 (-) 147 WP_003047126.1 50S ribosomal protein L33 -
  FGCSD_RS08035 - 1610501..1611717 (-) 1217 Protein_1527 multidrug efflux MFS transporter -
  FGCSD_RS08040 (FGCSD_1566) - 1611881..1613383 (-) 1503 WP_129556052.1 helicase HerA-like domain-containing protein -
  FGCSD_RS08045 (FGCSD_1567) - 1613494..1614177 (-) 684 WP_231112791.1 hypothetical protein -
  FGCSD_RS08055 - 1615341..1616167 (+) 827 Protein_1531 IS30 family transposase -
  FGCSD_RS08060 (FGCSD_1571) comE/blpR 1616571..1617320 (+) 750 WP_129556053.1 response regulator transcription factor Regulator
  FGCSD_RS08065 (FGCSD_1573) - 1618349..1618666 (-) 318 WP_115256692.1 type II toxin-antitoxin system RelE/ParE family toxin -
  FGCSD_RS08070 (FGCSD_1574) - 1618666..1618914 (-) 249 WP_012477809.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
  FGCSD_RS08075 (FGCSD_1575) - 1619537..1619824 (-) 288 WP_129556054.1 bacteriocin immunity protein -
  FGCSD_RS08080 (FGCSD_1577) - 1619934..1621045 (+) 1112 WP_089180045.1 IS3-like element IS981 family transposase -
  FGCSD_RS08085 (FGCSD_1579) - 1621378..1622483 (+) 1106 WP_129555101.1 IS3 family transposase -
  FGCSD_RS11170 - 1622591..1622838 (+) 248 Protein_1538 hypothetical protein -
  FGCSD_RS08090 - 1622860..1623114 (+) 255 WP_196772238.1 CPBP family intramembrane glutamic endopeptidase -
  FGCSD_RS08095 (FGCSD_1580) - 1623332..1624251 (+) 920 Protein_1540 hypothetical protein -
  FGCSD_RS08100 (FGCSD_1581) - 1624279..1624557 (-) 279 WP_129556055.1 StcA family protein -
  FGCSD_RS08105 (FGCSD_1582) - 1624595..1626196 (-) 1602 WP_129556056.1 transglutaminase domain-containing protein -
  FGCSD_RS11015 shp2 1626265..1626333 (-) 69 WP_134771781.1 peptide pheromone SHP2 -
  FGCSD_RS08110 (FGCSD_1583) rgg2 1626422..1627276 (+) 855 WP_129556401.1 quorum-sensing system transcriptional regulator Rgg2 -
  FGCSD_RS11105 - 1627288..1627446 (+) 159 WP_003049903.1 hypothetical protein -
  FGCSD_RS08115 (FGCSD_1584) mutM 1627458..1628285 (+) 828 WP_129556057.1 DNA-formamidopyrimidine glycosylase -
  FGCSD_RS08120 (FGCSD_1585) coaE 1628264..1628875 (+) 612 WP_172595998.1 dephospho-CoA kinase -
  FGCSD_RS08125 (FGCSD_1586) - 1629328..1630029 (+) 702 WP_129556059.1 ABC transporter ATP-binding protein -
  FGCSD_RS08130 (FGCSD_1587) - 1630019..1631044 (+) 1026 WP_231112792.1 hypothetical protein -
  FGCSD_RS08135 (FGCSD_1589) - 1631098..1632203 (+) 1106 WP_129555101.1 IS3 family transposase -
  FGCSD_RS11300 (FGCSD_1590) - 1632349..1632897 (-) 549 WP_231112795.1 hypothetical protein -
  FGCSD_RS11305 (FGCSD_1591) - 1632894..1633592 (-) 699 WP_232022239.1 hypothetical protein -
  FGCSD_RS08145 (FGCSD_1592) - 1633859..1634335 (-) 477 WP_129556060.1 NUDIX domain-containing protein -
  FGCSD_RS08150 (FGCSD_1593) era 1634522..1635418 (-) 897 WP_003047080.1 GTPase Era -
  FGCSD_RS08155 (FGCSD_1594) - 1635538..1635945 (-) 408 WP_003054389.1 diacylglycerol kinase -
  FGCSD_RS08160 (FGCSD_1595) ybeY 1635926..1636423 (-) 498 WP_003049887.1 rRNA maturation RNase YbeY -
  FGCSD_RS08165 (FGCSD_1596) - 1636582..1637157 (-) 576 WP_129556061.1 uracil-DNA glycosylase family protein -
  FGCSD_RS08170 (FGCSD_1597) - 1637204..1638265 (-) 1062 WP_129556062.1 PhoH family protein -
  FGCSD_RS08180 (FGCSD_1598) - 1638426..1640198 (-) 1773 WP_129556063.1 oleate hydratase -
  FGCSD_RS08185 (FGCSD_1599) - 1640509..1641729 (-) 1221 WP_129556064.1 LysM domain-containing protein -
  FGCSD_RS08190 (FGCSD_1600) - 1641869..1642084 (-) 216 WP_129556065.1 YozE family protein -
  FGCSD_RS08195 (FGCSD_1601) msrA 1642081..1642590 (-) 510 WP_129556066.1 peptide-methionine (S)-S-oxide reductase MsrA -
  FGCSD_RS08200 (FGCSD_1602) cvfB 1642662..1643519 (-) 858 WP_129556067.1 RNA-binding virulence regulatory protein CvfB -
  FGCSD_RS08205 (FGCSD_1603) frr 1643639..1644196 (-) 558 WP_111715585.1 ribosome recycling factor -
  FGCSD_RS08210 (FGCSD_1604) pyrH 1644224..1644952 (-) 729 WP_003049878.1 UMP kinase -
  FGCSD_RS08215 (FGCSD_1605) - 1645234..1645764 (+) 531 WP_129556068.1 hypothetical protein -
  FGCSD_RS08220 (FGCSD_1606) rplA 1646041..1646730 (-) 690 WP_003049876.1 50S ribosomal protein L1 -
  FGCSD_RS08225 (FGCSD_1607) rplK 1646836..1647261 (-) 426 WP_003049875.1 50S ribosomal protein L11 -
  FGCSD_RS08230 (FGCSD_1608) - 1647459..1648481 (-) 1023 WP_172595999.1 IS30 family transposase -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29257.56 Da        Isoelectric Point: 5.6284

>NTDB_id=70595 FGCSD_RS08060 WP_129556053.1 1616571..1617320(+) (comE/blpR) [Streptococcus dysgalactiae strain Kdys0611]
MNIFVLEDDFLQQTRIEKIIYKILTDNKWEINHLEVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNRD
PHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFTNVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide


Download         Length: 750 bp        

>NTDB_id=70595 FGCSD_RS08060 WP_129556053.1 1616571..1617320(+) (comE/blpR) [Streptococcus dysgalactiae strain Kdys0611]
ATGAATATTTTTGTCTTAGAGGACGATTTTTTACAACAAACTAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTGGGAGATTAACCACTTGGAAGTTTATGGTAAACCTAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAGAGAT
CCACACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTATCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTACTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-119)

LytTr DNA-binding domain (LytTR)

(150-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

55.328

97.992

0.542
  comE/comE1 Streptococcus equinus JB1

42.857

95.582

0.41
  comE/comE2 Streptococcus gordonii strain NCTC7865

40.476

100

0.41
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

40.476

100

0.41
  comE/comE2 Streptococcus equinus JB1

41.393

97.992

0.406
  comE Streptococcus mitis NCTC 12261

38.8

100

0.39
  comE Streptococcus mitis SK321

38.8

100

0.39
  comE Streptococcus pneumoniae TIGR4

38.4

100

0.386
  comE Streptococcus pneumoniae Rx1

38.4

100

0.386
  comE Streptococcus pneumoniae D39

38.4

100

0.386
  comE Streptococcus pneumoniae R6

38.4

100

0.386
  comE Streptococcus infantis strain Atu-4

38.306

99.598

0.382

Multiple sequence alignment