Detailed information NTG0690353

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: M8286_RS09520
• Genome accession: NZ_CP097577
• Coordinates: 1975882..1976619 (-)
• Length: 245 a.a.
• NCBI ID: WP_275601056.1
• Uniprot ID: -
• Organism: Streptococcus suis strain 3112
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1970882..1981619

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M8286_RS09495 (M8286_09650)	-	1971582..1972241 (+)	660	WP_275601053.1	metal-dependent transcriptional regulator	-
M8286_RS09500 (M8286_09655)	-	1972650..1972964 (-)	315	WP_358636561.1	CPBP family intramembrane glutamic endopeptidase	-
M8286_RS09505 (M8286_09660)	-	1973142..1973426 (-)	285	WP_275601054.1	hypothetical protein	-
M8286_RS09510 (M8286_09665)	-	1973948..1974367 (-)	420	WP_029171304.1	hypothetical protein	-
M8286_RS09515 (M8286_09670)	-	1974548..1975885 (-)	1338	WP_275601055.1	GHKL domain-containing protein	-
M8286_RS09520 (M8286_09675)	comE/blpR	1975882..1976619 (-)	738	WP_275601056.1	response regulator transcription factor	Regulator
M8286_RS09525 (M8286_09680)	-	1976836..1976979 (-)	144	WP_024416971.1	putative holin-like toxin	-
M8286_RS09530 (M8286_09685)	-	1977216..1977317 (-)	102	WP_153052760.1	putative holin-like toxin	-
M8286_RS09535 (M8286_09690)	-	1977471..1977656 (-)	186	WP_275601057.1	hypothetical protein	-
M8286_RS09540 (M8286_09695)	dtd	1977733..1978176 (-)	444	WP_358636568.1	D-aminoacyl-tRNA deacylase	-
M8286_RS09545 (M8286_09700)	-	1978178..1980379 (-)	2202	WP_275601058.1	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28381.30 Da
• Isoelectric Point: 5.6281

>NTDB_id=690353 M8286_RS09520 WP_275601056.1 1975882..1976619(-) (comE/blpR) [Streptococcus suis strain 3112]
MLNIFVLEDDFFQQSRLENAIRRCVEETSVRYKFLEVFGKPNQLLESIEEAGNHQFFFLDIEIKGEEKKGMEIAKEIRAR
DPYAVIVFVTTHSEFMPVTYRYRVSALDFIDKGLEDSDFQKAVSDVLVHAFENIDHTIAENSFVYKTETAHIQVPFSDIL
YFETSSTIHKVILKTKTGQTEFYGKVSDIAKADERLYQAHRSCVVNPLNITKLDRANHIAYFENGDSCFVSRLKQKKLAD
LLEIK

Nucleotide

• Length: 738 bp

>NTDB_id=690353 M8286_RS09520 WP_275601056.1 1975882..1976619(-) (comE/blpR) [Streptococcus suis strain 3112]
ATGCTTAATATTTTTGTATTAGAAGATGATTTTTTTCAGCAGAGTAGGCTAGAAAATGCTATTAGGCGGTGTGTTGAAGA
AACGTCAGTAAGATATAAATTCCTAGAAGTTTTTGGTAAACCAAATCAATTATTGGAATCAATCGAGGAAGCAGGCAATC
ACCAATTTTTCTTTTTAGATATTGAAATAAAAGGCGAAGAAAAGAAAGGAATGGAAATCGCTAAAGAAATTCGTGCTCGG
GATCCTTATGCTGTTATTGTCTTCGTAACAACTCACTCAGAATTTATGCCGGTAACGTATCGTTACCGGGTTTCTGCTTT
AGATTTTATAGATAAAGGTCTGGAGGATAGTGACTTTCAAAAGGCAGTATCAGATGTGTTAGTGCATGCTTTTGAAAATA
TTGATCATACTATAGCTGAAAATTCTTTTGTATACAAAACTGAAACTGCTCATATTCAAGTTCCTTTTAGTGACATTCTT
TATTTTGAAACATCATCAACAATACATAAAGTCATTTTAAAAACCAAAACAGGTCAGACTGAGTTTTACGGGAAAGTATC
CGATATAGCGAAAGCTGACGAACGACTTTACCAGGCACATCGTTCTTGTGTAGTGAATCCTTTAAATATAACGAAGTTGG
ATAGAGCAAACCACATTGCCTATTTTGAGAATGGAGATTCTTGTTTTGTTTCTCGTTTGAAGCAGAAGAAACTTGCAGAT
TTGCTGGAGATTAAATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-242)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	55.23	97.551	0.539
comE/comE1	Streptococcus equinus JB1	50	97.143	0.486
comE/comE2	Streptococcus equinus JB1	41.152	99.184	0.408
comE	Streptococcus mitis SK321	38.645	100	0.396
comE	Streptococcus pneumoniae R6	38.645	100	0.396
comE	Streptococcus pneumoniae TIGR4	38.645	100	0.396
comE	Streptococcus infantis strain Atu-4	38.645	100	0.396
comE	Streptococcus mitis NCTC 12261	38.645	100	0.396
comE	Streptococcus pneumoniae Rx1	38.645	100	0.396
comE	Streptococcus pneumoniae D39	38.645	100	0.396
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	38.71	100	0.392
comE/comE2	Streptococcus gordonii strain NCTC7865	38.71	100	0.392