Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   ML603_RS02415 Genome accession   NZ_CP092887
Coordinates   458226..458975 (+) Length   249 a.a.
NCBI ID   WP_129556053.1    Uniprot ID   -
Organism   Streptococcus dysgalactiae subsp. equisimilis strain Karl     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IScluster/Tn 459264..460369 458226..458975 flank 289


Gene organization within MGE regions


Location: 458226..460369
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ML603_RS02415 (ML603_02415) comE/blpR 458226..458975 (+) 750 WP_129556053.1 response regulator transcription factor Regulator

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29257.56 Da        Isoelectric Point: 5.6284

>NTDB_id=660919 ML603_RS02415 WP_129556053.1 458226..458975(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain Karl]
MNIFVLEDDFLQQTRIEKIIYKILTDNKWEINHLEVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNRD
PHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFTNVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide


Download         Length: 750 bp        

>NTDB_id=660919 ML603_RS02415 WP_129556053.1 458226..458975(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain Karl]
ATGAATATTTTTGTCTTAGAGGACGATTTTTTACAACAAACTAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTGGGAGATTAACCACTTGGAAGTTTATGGTAAACCTAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAGAGAT
CCACACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTATCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTACTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-119)

LytTr DNA-binding domain (LytTR)

(150-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

55.328

97.992

0.542
  comE/comE1 Streptococcus equinus JB1

42.857

95.582

0.41
  comE/comE2 Streptococcus gordonii strain NCTC7865

40.476

100

0.41
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

40.476

100

0.41
  comE/comE2 Streptococcus equinus JB1

41.393

97.992

0.406
  comE Streptococcus mitis NCTC 12261

38.8

100

0.39
  comE Streptococcus mitis SK321

38.8

100

0.39
  comE Streptococcus pneumoniae TIGR4

38.4

100

0.386
  comE Streptococcus pneumoniae Rx1

38.4

100

0.386
  comE Streptococcus pneumoniae D39

38.4

100

0.386
  comE Streptococcus pneumoniae R6

38.4

100

0.386
  comE Streptococcus infantis strain Atu-4

38.306

99.598

0.382