Detailed information NTG0064552

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SPB_RS07040
• Genome accession: NZ_AEUT02000001
• Coordinates: 1414976..1415713 (-)
• Length: 245 a.a.
• NCBI ID: WP_003104803.1
• Uniprot ID: F1YY51
• Organism: Streptococcus parauberis NCFD 2020
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1409976..1420713

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPB_RS07020 (SPB_1448)	-	1410608..1411420 (-)	813	WP_003105313.1	YidC/Oxa1 family membrane protein insertase	-
SPB_RS07025 (SPB_1449)	rnpA	1411404..1411769 (-)	366	WP_003106032.1	ribonuclease P protein component	-
SPB_RS07030 (SPB_1450)	argH	1411854..1413239 (-)	1386	WP_003102529.1	argininosuccinate lyase	-
SPB_RS07035 (SPB_1451)	-	1413279..1414481 (-)	1203	WP_003103497.1	argininosuccinate synthase	-
SPB_RS07040 (SPB_1452)	comE/blpR	1414976..1415713 (-)	738	WP_003104803.1	LytTR family DNA-binding domain-containing protein	Regulator
SPB_RS07045 (SPB_1453)	-	1415716..1416747 (-)	1032	WP_003103083.1	GHKL domain-containing protein	-
SPB_RS07050 (SPB_1454)	-	1417027..1418253 (-)	1227	WP_080558372.1	GHKL domain-containing protein	-
SPB_RS07055 (SPB_1455)	-	1418538..1419857 (-)	1320	WP_003104454.1	GHKL domain-containing protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28913.19 Da
• Isoelectric Point: 4.7047

>NTDB_id=64552 SPB_RS07040 WP_003104803.1 1414976..1415713(-) (comE/blpR) [Streptococcus parauberis NCFD 2020]
MNIFILEDDFIQQTRIESAIESILKENNISCKFMEVFSNPQKLYDAILEKGDHQIFFLDIEIQGESRKGLELATEIRQKD
PNAVIVFVTTHSEFAPISYKYKVSALDFIDKSVDTKQFKEQIQECIFYTNEMMSKNEPEDLFIFETSQTRLKMPLKDILY
FATSTTPHKVCLWTQTERLEFYGKLSEIQEVAPELFLCHRSYLINLDNVVRIDKFNQLVYFENGDDVMVSRLKMKSLIEK
WQELH

Nucleotide

• Length: 738 bp

>NTDB_id=64552 SPB_RS07040 WP_003104803.1 1414976..1415713(-) (comE/blpR) [Streptococcus parauberis NCFD 2020]
ATGAACATTTTTATATTAGAAGATGATTTTATCCAGCAAACTCGAATAGAATCAGCAATTGAAAGTATCCTCAAAGAAAA
TAATATAAGCTGCAAATTTATGGAAGTTTTTTCAAATCCCCAAAAGCTGTATGATGCCATCCTAGAAAAAGGTGACCATC
AGATTTTTTTCCTTGATATCGAAATTCAAGGAGAATCACGCAAGGGCTTGGAATTAGCAACTGAAATTCGTCAAAAAGAT
CCAAATGCAGTTATTGTTTTTGTGACGACTCATTCAGAGTTTGCTCCAATTTCCTATAAATATAAAGTGTCAGCACTTGA
TTTTATTGATAAGTCGGTTGATACTAAGCAATTTAAGGAACAAATACAAGAATGTATTTTTTACACGAATGAGATGATGT
CAAAAAACGAACCAGAAGATCTCTTTATTTTTGAGACATCTCAAACTAGACTAAAAATGCCACTAAAGGATATCCTTTAC
TTTGCAACTTCAACAACACCCCATAAAGTTTGTTTGTGGACACAAACAGAACGACTCGAGTTTTATGGTAAATTATCTGA
AATTCAAGAAGTAGCACCAGAGTTATTTCTCTGTCACCGTTCTTACTTGATTAATCTTGATAATGTTGTTCGAATTGATA
AATTTAATCAATTAGTCTATTTTGAAAATGGTGATGATGTTATGGTCTCACGACTCAAAATGAAAAGTTTAATTGAAAAA
TGGCAAGAATTACACTAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-122)

3D structure

• AlphaFold DB: F1YY51

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	52.101	97.143	0.506
comE/comE2	Streptococcus equinus JB1	43.033	99.592	0.429
comE/comE1	Streptococcus equinus JB1	42.857	97.143	0.416
comE/comE2	Streptococcus gordonii strain NCTC7865	39.918	99.184	0.396
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.918	99.184	0.396
comE	Streptococcus pneumoniae D39	37.603	98.776	0.371
comE	Streptococcus pneumoniae Rx1	37.603	98.776	0.371
comE	Streptococcus pneumoniae R6	37.603	98.776	0.371
comE	Streptococcus pneumoniae TIGR4	37.603	98.776	0.371
comE	Streptococcus mitis NCTC 12261	37.759	98.367	0.371
comE	Streptococcus mitis SK321	37.759	98.367	0.371
comE	Streptococcus infantis strain Atu-4	36.777	98.776	0.363