Detailed information NTG0061565

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SII_RS09520
• Genome accession: NC_022237
• Coordinates: 1955302..1956051 (-)
• Length: 249 a.a.
• NCBI ID: WP_003075488.1
• Uniprot ID: T1ZH01
• Organism: Streptococcus intermedius C270
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1950302..1961051

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SII_RS09500 (SII_1863)	-	1950706..1952328 (+)	1623	WP_020999300.1	ATP-binding cassette domain-containing protein	-
SII_RS09505 (SII_1864)	-	1952402..1954978 (+)	2577	WP_020999301.1	YfhO family protein	-
SII_RS09520 (SII_1867)	comE	1955302..1956051 (-)	750	WP_003075488.1	competence system response regulator transcription factor ComE	Regulator
SII_RS09525 (SII_1868)	comD/comD1	1956051..1957376 (-)	1326	WP_003075490.1	GHKL domain-containing protein	Regulator
SII_RS09860 (SII_1869)	-	1957393..1957539 (-)	147	WP_003075491.1	bacteriocin	-
SII_RS09540 (SII_1871)	rlmH	1957816..1958295 (-)	480	WP_003075603.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SII_RS09545 (SII_1872)	htrA	1958499..1959689 (+)	1191	WP_020999302.1	S1C family serine protease	Regulator
SII_RS09550 (SII_1873)	spo0J	1959744..1960511 (+)	768	WP_020999303.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29207.78 Da
• Isoelectric Point: 8.0443

>NTDB_id=61565 SII_RS09520 WP_003075488.1 1955302..1956051(-) (comE) [Streptococcus intermedius C270]
MKVLVLEDEISHQVRMETTLAEIAKEMGISIKVKVTGKIREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLNDVAFKKHIKDSIEYTKATLIENKDMVDYFEYSFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDKETQRFFSPHKSYLVNIGNIKSYDKKMKEIIFYEDHRCPITRMKIGKL
KTILEESKG

Nucleotide

• Length: 750 bp

>NTDB_id=61565 SII_RS09520 WP_003075488.1 1955302..1956051(-) (comE) [Streptococcus intermedius C270]
ATGAAAGTATTAGTATTAGAAGATGAAATTTCACATCAAGTAAGAATGGAAACAACTTTGGCAGAGATTGCAAAAGAAAT
GGGAATTTCTATCAAAGTTAAAGTAACTGGAAAAATAAGAGAATTTAAAGAATATATTGAGAATGATGAAGTAAATCAAT
TATACTTTTTAGATATTGATATTAAAGGGGAAGAGACAAAAGGTTTAGAAATAGCAAAATTTATACGTCATCATAATCCG
TATGCTATTATTGTTTTTGTTACAACGAAATCAGAATTTGCTACTATGACTTTTAAATATAAAGTTTCTGCACTAGATTT
TGTTGATAAAAATTTGAATGATGTTGCTTTTAAAAAACATATAAAAGATAGTATCGAGTATACAAAAGCAACGTTGATTG
AAAATAAAGATATGGTTGATTATTTTGAATATAGTTTTCGTGGTGGAGAAGTTAGAATGCCATTTAATGATATTTTATAT
ATTGAAACGACAGGTTCTTCTCATAAATTAAGAATTGTAGGTAAAAACTTTTTTAAAGAATTTTATGGTACTATTGCAGA
TATTCAAGAAAAAGACAAGGAGACACAGCGTTTCTTTTCACCTCATAAATCTTATTTAGTTAATATTGGAAATATTAAGA
GTTATGACAAAAAAATGAAAGAAATTATTTTTTATGAAGATCACCGTTGCCCAATTACTCGAATGAAAATTGGAAAGTTG
AAAACTATTTTAGAGGAGTCAAAAGGATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (152-244)

3D structure

• AlphaFold DB: T1ZH01

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	71.02	98.394	0.699
comE/comE2	Streptococcus gordonii strain NCTC7865	71.311	97.992	0.699
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	71.311	97.992	0.699
comE	Streptococcus infantis strain Atu-4	70.612	98.394	0.695
comE	Streptococcus mitis SK321	70.204	98.394	0.691
comE	Streptococcus pneumoniae Rx1	69.796	98.394	0.687
comE	Streptococcus pneumoniae D39	69.796	98.394	0.687
comE	Streptococcus pneumoniae R6	69.796	98.394	0.687
comE	Streptococcus pneumoniae TIGR4	69.796	98.394	0.687
comE/blpR	Streptococcus mutans UA159	40.161	100	0.402
comE/comE2	Streptococcus equinus JB1	35.019	100	0.361