Detailed information NTG0606833

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: LA346_RS04820
• Genome accession: NZ_CP083627
• Coordinates: 904029..904781 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain FDAARGOS_1508
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 899029..909781

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LA346_RS10990	-	901462..903065 (-)	1604	Protein_914	YhgE/Pip family protein	-
LA346_RS04805 (LA346_04805)	-	903244..903786 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
LA346_RS04820 (LA346_04820)	comE	904029..904781 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
LA346_RS04825 (LA346_04825)	comD/comD1	904778..906103 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
LA346_RS04830 (LA346_04830)	comC/comC1	906124..906249 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
LA346_RS04840 (LA346_04840)	rlmH	906531..907010 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
LA346_RS04845 (LA346_04845)	htrA	907193..908374 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
LA346_RS04850 (LA346_04850)	spo0J	908432..909190 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=606833 LA346_RS04820 WP_000866065.1 904029..904781(-) (comE) [Streptococcus pneumoniae strain FDAARGOS_1508]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=606833 LA346_RS04820 WP_000866065.1 904029..904781(-) (comE) [Streptococcus pneumoniae strain FDAARGOS_1508]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAAGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408