Detailed information NTG0602223

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: K7G42_RS10635
• Genome accession: NZ_CP082783
• Coordinates: 2020254..2020991 (-)
• Length: 245 a.a.
• NCBI ID: WP_003107762.1
• Uniprot ID: A0A0E2UAG5
• Organism: Streptococcus parauberis strain KRS02083
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 2015254..2025991

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K7G42_RS10615 (K7G42_10535)	-	2015887..2016699 (-)	813	WP_003105313.1	YidC/Oxa1 family membrane protein insertase	-
K7G42_RS10620 (K7G42_10540)	rnpA	2016683..2017048 (-)	366	WP_003106032.1	ribonuclease P protein component	-
K7G42_RS10625 (K7G42_10545)	argH	2017133..2018518 (-)	1386	WP_004347270.1	argininosuccinate lyase	-
K7G42_RS10630 (K7G42_10550)	-	2018558..2019760 (-)	1203	WP_003107761.1	argininosuccinate synthase	-
K7G42_RS10635 (K7G42_10555)	comE/blpR	2020254..2020991 (-)	738	WP_003107762.1	LytTR family DNA-binding domain-containing protein	Regulator
K7G42_RS10640 (K7G42_10560)	-	2020994..2022025 (-)	1032	WP_004347269.1	GHKL domain-containing protein	-
K7G42_RS10645 (K7G42_10565)	-	2022305..2023651 (-)	1347	WP_037620084.1	GHKL domain-containing protein	-
K7G42_RS10650 (K7G42_10570)	-	2023816..2025135 (-)	1320	WP_004347268.1	GHKL domain-containing protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28923.23 Da
• Isoelectric Point: 4.7047

>NTDB_id=602223 K7G42_RS10635 WP_003107762.1 2020254..2020991(-) (comE/blpR) [Streptococcus parauberis strain KRS02083]
MNIFILEDDFIQQTRIESAIESILKENNISCKFMEVFSNPQKLYDAILEKGDHQIFFLDIEIQGESRKGLELATEIRQKD
PNAVIVFVTTHSEFAPISYKYKVSALDFIDKSVDTKQFKEQIQECIFYTNEMMSKNEPEDLFIFETPQTRLKMPLKDILY
FATSTTPHKVCLWTQTERLEFYGKLSEIQEVAPELFLCHRSYLINLDNVVRIDKFNQLVYFENGDDVMVSRLKMKSLIEK
WQELH

Nucleotide

• Length: 738 bp

>NTDB_id=602223 K7G42_RS10635 WP_003107762.1 2020254..2020991(-) (comE/blpR) [Streptococcus parauberis strain KRS02083]
ATGAACATTTTTATATTAGAAGATGATTTTATCCAGCAAACTCGAATAGAATCAGCAATTGAAAGTATCCTCAAAGAAAA
TAATATAAGCTGCAAATTTATGGAAGTTTTTTCAAATCCCCAAAAGCTGTATGATGCCATCCTAGAAAAAGGTGACCATC
AGATTTTTTTCCTTGATATCGAAATTCAAGGAGAATCACGCAAGGGCTTGGAATTAGCAACTGAAATTCGTCAAAAAGAT
CCAAATGCAGTTATTGTTTTTGTGACGACTCATTCAGAGTTTGCTCCAATTTCCTATAAATATAAAGTGTCAGCACTTGA
TTTTATTGATAAGTCGGTTGATACTAAGCAATTTAAGGAACAAATACAAGAATGTATTTTTTACACGAATGAGATGATGT
CAAAAAACGAACCAGAAGATCTCTTTATTTTTGAGACACCTCAAACTAGACTAAAAATGCCACTAAAGGATATCCTTTAC
TTTGCAACTTCAACAACACCCCATAAAGTTTGTTTGTGGACACAAACAGAACGACTCGAGTTTTATGGTAAATTATCTGA
AATTCAAGAAGTAGCACCAGAGTTATTTCTCTGTCACCGTTCTTACTTGATTAATCTTGATAATGTTGTTCGAATTGATA
AATTTAATCAATTAGTCTATTTTGAAAATGGTGATGATGTTATGGTCTCACGACTCAAAATGAAAAGTTTAATTGAAAAA
TGGCAAGAATTACACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A0E2UAG5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	51.681	97.143	0.502
comE/comE2	Streptococcus equinus JB1	43.033	99.592	0.429
comE/comE1	Streptococcus equinus JB1	42.857	97.143	0.416
comE/comE2	Streptococcus gordonii strain NCTC7865	39.918	99.184	0.396
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.918	99.184	0.396
comE	Streptococcus pneumoniae D39	37.603	98.776	0.371
comE	Streptococcus pneumoniae Rx1	37.603	98.776	0.371
comE	Streptococcus pneumoniae R6	37.603	98.776	0.371
comE	Streptococcus pneumoniae TIGR4	37.603	98.776	0.371
comE	Streptococcus mitis NCTC 12261	37.759	98.367	0.371
comE	Streptococcus mitis SK321	37.759	98.367	0.371
comE	Streptococcus infantis strain Atu-4	36.777	98.776	0.363