Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   K6969_RS11815 Genome accession   NZ_CP082205
Coordinates   2459609..2460346 (-) Length   245 a.a.
NCBI ID   WP_029173665.1    Uniprot ID   -
Organism   Streptococcus suis strain AKJ18     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 2453665..2479772 2459609..2460346 within 0


Gene organization within MGE regions


Location: 2453665..2479772
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K6969_RS11755 (K6969_11640) - 2453914..2454333 (-) 420 WP_171943127.1 hypothetical protein -
  K6969_RS11760 (K6969_11645) - 2454572..2454859 (+) 288 WP_044687433.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  K6969_RS11765 (K6969_11650) - 2454849..2455190 (+) 342 WP_171943128.1 type II toxin-antitoxin system RelE/ParE family toxin -
  K6969_RS11770 (K6969_11655) - 2455285..2455479 (-) 195 WP_171943129.1 hypothetical protein -
  K6969_RS11775 (K6969_11660) - 2455501..2456202 (-) 702 WP_029173661.1 CPBP family intramembrane glutamic endopeptidase -
  K6969_RS11780 (K6969_11665) - 2456457..2456621 (-) 165 WP_153309455.1 hypothetical protein -
  K6969_RS11785 (K6969_11670) - 2456839..2457048 (-) 210 WP_029173662.1 hypothetical protein -
  K6969_RS11790 (K6969_11675) - 2457159..2457368 (-) 210 WP_029173663.1 hypothetical protein -
  K6969_RS11795 (K6969_11680) - 2457678..2457845 (-) 168 WP_153309456.1 hypothetical protein -
  K6969_RS11800 (K6969_11685) - 2457927..2458091 (-) 165 WP_153309457.1 hypothetical protein -
  K6969_RS11805 (K6969_11690) - 2458270..2459337 (-) 1068 WP_321537421.1 sensor histidine kinase -
  K6969_RS11810 - 2459346..2459609 (-) 264 WP_029945698.1 hypothetical protein -
  K6969_RS11815 (K6969_11695) comE/blpR 2459609..2460346 (-) 738 WP_029173665.1 response regulator transcription factor Regulator
  K6969_RS11820 (K6969_11700) - 2461310..2461495 (-) 186 WP_024379357.1 hypothetical protein -
  K6969_RS11825 (K6969_11705) dtd 2461557..2462000 (-) 444 WP_029173667.1 D-aminoacyl-tRNA deacylase -
  K6969_RS11830 (K6969_11710) - 2462002..2464203 (-) 2202 WP_171943058.1 RelA/SpoT family protein -
  K6969_RS11835 (K6969_11715) - 2464460..2466937 (+) 2478 WP_029173669.1 bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase -
  K6969_RS11840 (K6969_11720) - 2466984..2467700 (-) 717 WP_029173670.1 DUF554 domain-containing protein -
  K6969_RS11845 (K6969_11725) - 2467704..2468450 (-) 747 WP_321537422.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
  K6969_RS11850 (K6969_11730) prmA 2468452..2469405 (-) 954 WP_029173672.1 50S ribosomal protein L11 methyltransferase -
  K6969_RS11855 (K6969_11735) - 2470001..2470354 (-) 354 WP_029173673.1 ASCH domain-containing protein -
  K6969_RS11860 (K6969_11740) - 2470356..2470826 (-) 471 Protein_2314 DUF3013 family protein -
  K6969_RS11865 (K6969_11745) - 2470829..2471164 (-) 336 WP_029173675.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
  K6969_RS11870 (K6969_11750) - 2471234..2472520 (+) 1287 WP_171943056.1 replication-associated recombination protein A -
  K6969_RS11885 (K6969_11765) nrdG 2473001..2473558 (-) 558 WP_171943055.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  K6969_RS11890 (K6969_11770) - 2473745..2474239 (-) 495 WP_024411030.1 GNAT family N-acetyltransferase -
  K6969_RS11895 (K6969_11775) - 2474241..2475485 (-) 1245 Protein_2319 bifunctional metallophosphatase/5'-nucleotidase -
  K6969_RS11900 (K6969_11780) - 2475799..2476920 (+) 1122 WP_015445098.1 IS110 family transposase -
  K6969_RS11905 (K6969_11785) - 2477292..2477921 (+) 630 Protein_2321 transposase -
  K6969_RS11910 (K6969_11790) - 2478434..2478583 (+) 150 Protein_2322 IS982 family transposase -
  K6969_RS11915 (K6969_11795) - 2478596..2478856 (-) 261 WP_029173656.1 hypothetical protein -
  K6969_RS11920 (K6969_11800) - 2478929..2479387 (+) 459 WP_029173657.1 hypothetical protein -
  K6969_RS11925 - 2479638..2479772 (-) 135 WP_002939130.1 hypothetical protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28411.24 Da        Isoelectric Point: 5.2150

>NTDB_id=600068 K6969_RS11815 WP_029173665.1 2459609..2460346(-) (comE/blpR) [Streptococcus suis strain AKJ18]
MLNIFVLEDDFFQQSRLENAIRQCVEETSVRYKFLEVFGKPNQLLESIEEAGNHQFFFLDIEIKGEEKKGMEIAKEIRAR
DPYAVIVFVTTHSEFMPVTYRYRVSALDFIDKGLEDSDFQKAVSDVLVHAFENIDHTIAENSFIYKTETAHIQVPFSDIL
YFETSSTIHKVILKTKTGQTEFYGKVSDIAKADERLYQAHRSCVVNPLNITRLDRTNHIAYFENGDSCFVSRLKQKKLAD
LLEIN

Nucleotide


Download         Length: 738 bp        

>NTDB_id=600068 K6969_RS11815 WP_029173665.1 2459609..2460346(-) (comE/blpR) [Streptococcus suis strain AKJ18]
ATGCTTAATATTTTTGTATTAGAAGATGATTTTTTTCAGCAGAGCAGGCTAGAAAATGCTATTAGGCAGTGTGTTGAAGA
AACGTCAGTAAGATATAAATTCCTAGAAGTTTTTGGTAAACCAAATCAATTATTGGAATCAATCGAGGAAGCGGGGAATC
ACCAATTTTTCTTTTTAGATATTGAAATTAAAGGCGAAGAAAAGAAAGGAATGGAAATCGCTAAAGAAATCCGTGCTCGC
GATCCCTATGCTGTTATTGTCTTTGTAACAACTCACTCAGAATTTATGCCGGTAACGTATCGTTATCGAGTCTCTGCTTT
AGATTTTATAGATAAAGGCCTAGAGGATAGTGACTTTCAAAAGGCAGTATCAGATGTGTTGGTGCATGCTTTTGAAAATA
TTGATCATACTATAGCTGAAAATTCTTTTATATATAAAACTGAAACTGCTCATATTCAAGTCCCTTTTAGTGATATCCTT
TATTTTGAAACATCATCAACAATACATAAAGTCATTTTAAAAACCAAAACAGGTCAGACTGAGTTTTACGGGAAAGTATC
CGATATAGCGAAAGCAGATGAACGACTTTACCAGGCACATCGTTCTTGTGTAGTGAATCCATTAAATATAACGAGATTGG
ACAGAACAAACCATATTGCCTATTTTGAGAATGGAGATTCTTGTTTTGTTTCTCGTTTGAAGCAGAAGAAACTTGCAGAT
TTGTTGGAGATTAATTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(152-242)

Response regulator receiver domain (Response_reg)

(4-123)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

56.067

97.551

0.547
  comE/comE1 Streptococcus equinus JB1

50

97.143

0.486
  comE/comE2 Streptococcus equinus JB1

41.152

99.184

0.408
  comE Streptococcus pneumoniae TIGR4

38.554

100

0.392
  comE Streptococcus pneumoniae D39

38.554

100

0.392
  comE Streptococcus pneumoniae R6

38.554

100

0.392
  comE Streptococcus infantis strain Atu-4

38.554

100

0.392
  comE Streptococcus mitis NCTC 12261

38.554

100

0.392
  comE Streptococcus mitis SK321

38.554

100

0.392
  comE Streptococcus pneumoniae Rx1

38.554

100

0.392
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

38.618

100

0.388
  comE/comE2 Streptococcus gordonii strain NCTC7865

38.618

100

0.388