Detailed information NTG0600015

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: K6974_RS12570
• Genome accession: NZ_CP082204
• Coordinates: 2512710..2513447 (-)
• Length: 245 a.a.
• NCBI ID: WP_172027228.1
• Uniprot ID: -
• Organism: Streptococcus suis strain FJSM5
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	2511370..2532751	2512710..2513447	within	0

Gene organization within MGE regions

Location: 2511370..2532751

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K6974_RS12565 (K6974_12435)	-	2511370..2512710 (-)	1341	WP_222337178.1	GHKL domain-containing protein	-
K6974_RS12570 (K6974_12440)	comE/blpR	2512710..2513447 (-)	738	WP_172027228.1	response regulator transcription factor	Regulator
K6974_RS12575 (K6974_12445)	-	2513663..2513737 (-)	75	WP_236659579.1	hypothetical protein	-
K6974_RS12580 (K6974_12450)	-	2514039..2514224 (-)	186	WP_029179635.1	hypothetical protein	-
K6974_RS12585 (K6974_12455)	dtd	2514287..2514730 (-)	444	WP_002941990.1	D-aminoacyl-tRNA deacylase	-
K6974_RS12590 (K6974_12460)	-	2514732..2516933 (-)	2202	WP_024379359.1	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	-
K6974_RS12595 (K6974_12465)	-	2517190..2519673 (+)	2484	WP_222337176.1	bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase	-
K6974_RS12600 (K6974_12470)	-	2519722..2520435 (-)	714	WP_222337175.1	DUF554 domain-containing protein	-
K6974_RS12605 (K6974_12475)	-	2520439..2521185 (-)	747	WP_222337174.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
K6974_RS12610 (K6974_12480)	prmA	2521187..2522140 (-)	954	WP_222337173.1	50S ribosomal protein L11 methyltransferase	-
K6974_RS12615 (K6974_12485)	-	2522609..2522962 (-)	354	WP_222337172.1	ASCH domain-containing protein	-
K6974_RS12620 (K6974_12490)	-	2522964..2523434 (-)	471	WP_099808927.1	DUF3013 family protein	-
K6974_RS12625 (K6974_12495)	-	2523436..2523771 (-)	336	WP_029187566.1	MazG nucleotide pyrophosphohydrolase domain-containing protein	-
K6974_RS12630 (K6974_12500)	-	2523841..2525121 (+)	1281	WP_222337171.1	replication-associated recombination protein A	-
K6974_RS12645 (K6974_12515)	nrdG	2525562..2526134 (-)	573	WP_222337170.1	anaerobic ribonucleoside-triphosphate reductase activating protein	-
K6974_RS12650 (K6974_12520)	-	2526149..2526640 (-)	492	WP_222337169.1	GNAT family N-acetyltransferase	-
K6974_RS12655 (K6974_12525)	-	2526642..2527988 (-)	1347	WP_222337168.1	bifunctional UDP-sugar hydrolase/5'-nucleotidase	-
K6974_RS12660	-	2527990..2528124 (-)	135	WP_105130096.1	hypothetical protein	-
K6974_RS12665 (K6974_12530)	nrdD	2528216..2530387 (-)	2172	WP_222337167.1	anaerobic ribonucleoside-triphosphate reductase	-
K6974_RS12670 (K6974_12535)	-	2530531..2530704 (-)	174	WP_024376201.1	hypothetical protein	-
K6974_RS12675 (K6974_12540)	-	2530738..2531178 (-)	441	WP_024377585.1	DUF3021 domain-containing protein	-
K6974_RS12680 (K6974_12545)	-	2531175..2531618 (-)	444	WP_024376203.1	LytTR family DNA-binding domain-containing protein	-
K6974_RS12685 (K6974_12550)	-	2531787..2532188 (-)	402	WP_024376204.1	hypothetical protein	-
K6974_RS12690 (K6974_12555)	-	2532203..2532751 (-)	549	WP_024376205.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28354.19 Da
• Isoelectric Point: 5.2226

>NTDB_id=600015 K6974_RS12570 WP_172027228.1 2512710..2513447(-) (comE/blpR) [Streptococcus suis strain FJSM5]
MLNIFVLEDDFFQQSRLENAIRRCVEETSVRYKFLEVFGKPNQLLESIEEAGNHQFFFLDIEIKGEEKKGMEIAKEIRAR
DPYAVIVFVTTHSEFMPVTYRYRVSALDFIDKGLEDSDFQKAVSDVLVHAFENIDHTVAENSFVYKTETAHIQVPFSDIL
YFETSSTIHKVILKTKTGQTEFYGKVSDIAKADERLYQAHRSCVVNPLNITKLDRANHIAYFENGDSCFVSRLKQKKLAD
LLEID

Nucleotide

• Length: 738 bp

>NTDB_id=600015 K6974_RS12570 WP_172027228.1 2512710..2513447(-) (comE/blpR) [Streptococcus suis strain FJSM5]
ATGCTTAATATTTTTGTATTAGAAGATGATTTTTTTCAGCAGAGTAGGCTAGAAAATGCTATTAGGCGGTGTGTTGAAGA
AACGTCAGTAAGGTATAAATTCCTAGAAGTTTTTGGTAAACCAAATCAATTATTGGAATCAATCGAGGAAGCGGGGAATC
ACCAATTTTTCTTTTTAGATATTGAAATAAAAGGCGAAGAAAAGAAAGGCATGGAAATCGCTAAAGAAATCCGTGCTCGC
GATCCCTATGCTGTTATTGTCTTTGTAACGACACACTCAGAATTTATGCCGGTAACATATCGTTATCGGGTTTCTGCTTT
AGATTTTATAGATAAAGGCCTGGAGGATAGTGACTTTCAAAAGGCAGTATCAGATGTCTTAGTGCATGCTTTTGAAAATA
TTGATCATACTGTAGCTGAAAATTCTTTTGTATACAAAACTGAAACTGCTCATATTCAAGTTCCTTTTAGTGACATCCTT
TATTTTGAAACATCATCAACAATACATAAAGTCATTTTAAAAACGAAAACAGGTCAGACTGAGTTTTACGGGAAAGTATC
CGATATAGCGAAAGCAGATGAACGACTTTACCAAGCACATCGTTCTTGTGTAGTGAATCCTTTAAATATAACGAAGTTGG
ACAGAGCAAACCATATTGCCTATTTTGAGAATGGAGATTCTTGTTTTGTTTCTCGTTTGAAGCAGAAGAAACTTGCAGAT
TTGTTGGAGATTGATTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	55.23	97.551	0.539
comE/comE1	Streptococcus equinus JB1	50	97.143	0.486
comE/comE2	Streptococcus equinus JB1	40.741	99.184	0.404
comE	Streptococcus mitis SK321	38.554	100	0.392
comE	Streptococcus pneumoniae R6	38.554	100	0.392
comE	Streptococcus pneumoniae TIGR4	38.554	100	0.392
comE	Streptococcus infantis strain Atu-4	38.554	100	0.392
comE	Streptococcus mitis NCTC 12261	38.554	100	0.392
comE	Streptococcus pneumoniae Rx1	38.554	100	0.392
comE	Streptococcus pneumoniae D39	38.554	100	0.392
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	38.618	100	0.388
comE/comE2	Streptococcus gordonii strain NCTC7865	38.618	100	0.388