Detailed information NTG0058447

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: I872_RS05505
• Genome accession: NC_021175
• Coordinates: 1102306..1103037 (-)
• Length: 243 a.a.
• NCBI ID: WP_015605157.1
• Uniprot ID: A0A512A9N5
• Organism: Streptococcus cristatus AS 1.3089
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1097306..1108037

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I872_RS05485 (I872_05505)	-	1097826..1098986 (-)	1161	WP_015605153.1	ABC transporter permease subunit	-
I872_RS05490 (I872_05510)	-	1098983..1099846 (-)	864	WP_015605154.1	ABC transporter ATP-binding protein	-
I872_RS05500 (I872_05520)	-	1100939..1102273 (-)	1335	WP_015605156.1	sensor histidine kinase	-
I872_RS05505 (I872_05525)	comE/blpR	1102306..1103037 (-)	732	WP_015605157.1	response regulator transcription factor	Regulator
I872_RS05510 (I872_05530)	-	1103039..1103380 (-)	342	WP_015605158.1	LytTR family DNA-binding domain-containing protein	-
I872_RS05515 (I872_05535)	-	1103563..1104135 (-)	573	WP_015605159.1	TetR/AcrR family transcriptional regulator	-
I872_RS05520 (I872_05540)	-	1104262..1105104 (+)	843	WP_015605160.1	DegV family protein	-
I872_RS05525 (I872_05545)	-	1105195..1105965 (+)	771	Protein_1078	XRE family transcriptional regulator	-
I872_RS05530 (I872_05550)	-	1106147..1106839 (-)	693	WP_015605162.1	phosphoglycerate mutase	-
I872_RS05535 (I872_05555)	-	1106991..1107443 (-)	453	WP_015605163.1	Fur family transcriptional regulator	-

Sequence

Protein

• Length: 243 a.a.
• Molecular weight: 28706.87 Da
• Isoelectric Point: 5.4721

>NTDB_id=58447 I872_RS05505 WP_015605157.1 1102306..1103037(-) (comE/blpR) [Streptococcus cristatus AS 1.3089]
MKIFVLEDDLKQQAYMESTIKGILEKNGWECQFLEIYGKPDMLIDAVRERGSHQIFFLDIEIKQETQKGLEVAGKIRKLD
PYALIVFVTTHSEFMPLTFRYQVSAFDFIDKGLPEEDFIKQIEQDLAYLYERKDSFQAEETFVFENSKSDFQVPFSEIYY
FETSEVPHRLVLYTKKERIEFYGQLSEITKQDKRLYRCHRSYVVNPANISQLDKIENIAYFPNGASCYVSRLKMKGLRAA
LRQ

Nucleotide

• Length: 732 bp

>NTDB_id=58447 I872_RS05505 WP_015605157.1 1102306..1103037(-) (comE/blpR) [Streptococcus cristatus AS 1.3089]
ATGAAAATTTTTGTATTAGAAGACGATCTTAAGCAACAAGCCTATATGGAGTCAACCATTAAGGGAATTTTGGAAAAGAA
TGGCTGGGAATGCCAGTTTTTAGAAATCTACGGCAAGCCGGACATGCTGATTGATGCAGTAAGGGAACGGGGGAGTCATC
AGATTTTCTTTTTGGATATTGAGATTAAGCAAGAGACGCAGAAGGGACTAGAGGTGGCAGGAAAGATTCGCAAGTTGGAT
CCCTATGCTCTGATTGTATTTGTGACGACTCACTCAGAATTTATGCCCTTGACTTTTCGCTATCAGGTATCAGCTTTTGA
CTTTATTGATAAAGGTTTGCCTGAGGAAGATTTTATCAAGCAGATTGAGCAGGACCTAGCCTATCTTTATGAGAGAAAGG
ACAGTTTTCAAGCTGAAGAAACTTTTGTCTTTGAAAATTCCAAATCAGATTTTCAGGTGCCTTTTAGTGAAATCTATTAT
TTTGAGACATCAGAAGTGCCTCATAGACTCGTTCTCTATACCAAGAAAGAGCGGATCGAATTTTACGGACAGCTTTCTGA
GATTACAAAGCAGGACAAGCGTCTCTATCGGTGTCATCGCTCTTATGTGGTCAATCCAGCGAATATCTCTCAGCTGGATA
AGATAGAAAACATAGCCTATTTTCCTAATGGCGCTAGTTGCTATGTATCACGCCTCAAGATGAAAGGATTGCGGGCAGCT
TTAAGGCAGTAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-122)

3D structure

• AlphaFold DB: A0A512A9N5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	57.438	99.588	0.572
comE/comE1	Streptococcus equinus JB1	45.868	99.588	0.457
comE/comE2	Streptococcus equinus JB1	44.398	99.177	0.44
comE/comE2	Streptococcus gordonii strain NCTC7865	37.751	100	0.387
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.751	100	0.387
comE	Streptococcus infantis strain Atu-4	36.4	100	0.374
comE	Streptococcus mitis NCTC 12261	35.6	100	0.366
comE	Streptococcus mitis SK321	35.6	100	0.366
comE	Streptococcus pneumoniae Rx1	35.6	100	0.366
comE	Streptococcus pneumoniae D39	35.6	100	0.366
comE	Streptococcus pneumoniae R6	35.6	100	0.366
comE	Streptococcus pneumoniae TIGR4	35.6	100	0.366