Detailed information NTG0580331

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: I6L86_RS00390
• Genome accession: NZ_CP077259
• Coordinates: 75222..75962 (-)
• Length: 246 a.a.
• NCBI ID: WP_001019941.1
• Uniprot ID: A0AAX2L835
• Organism: Streptococcus mitis strain FDAARGOS 1456
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 70222..80962

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6L86_RS00365 (I6L86_00365)	-	71333..71632 (-)	300	WP_000361394.1	bacteriocin immunity protein	-
I6L86_RS00375 (I6L86_00375)	-	72910..73302 (-)	393	WP_000443464.1	hypothetical protein	-
I6L86_RS00380 (I6L86_00380)	-	73363..73527 (-)	165	WP_000448735.1	Blp family class II bacteriocin	-
I6L86_RS00385 (I6L86_00385)	-	73886..75211 (-)	1326	WP_000575877.1	GHKL domain-containing protein	-
I6L86_RS00390 (I6L86_00390)	comE/blpR	75222..75962 (-)	741	WP_001019941.1	response regulator transcription factor	Regulator
I6L86_RS00395 (I6L86_00395)	-	75973..76305 (-)	333	WP_000656278.1	LytTR family DNA-binding domain-containing protein	-
I6L86_RS08965	-	76688..76903 (+)	216	WP_000780967.1	hypothetical protein	-
I6L86_RS00410 (I6L86_00410)	-	77166..78509 (-)	1344	WP_004238723.1	DEAD/DEAH box helicase	-
I6L86_RS00415 (I6L86_00415)	-	78648..79463 (-)	816	WP_000670854.1	endonuclease/exonuclease/phosphatase family protein	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28746.12 Da
• Isoelectric Point: 5.9117

>NTDB_id=580331 I6L86_RS00390 WP_001019941.1 75222..75962(-) (comE/blpR) [Streptococcus mitis strain FDAARGOS 1456]
MNIFILEDNFLQQTRIENVVKKILVDNKIEYRHFEVYGKPQQLLEDISERGNHQLFLLDIEIKDDDKRGLDVAREIRKLD
SQAVIAFVTSHSEFMPVSFEYLVSAIDFIDKELPEPLFIKRIENVILSVSDNQGITVSEDSFIFTGSKAQIQVPFKDLLY
IETSTIAHKLTLYSKRDIVEFYGQLSDILKQEPRLFQCHRSFIVNPYNISLIDKENRLVHFQNGSSCIVSRLKIRPLMKV
IERLHD

Nucleotide

• Length: 741 bp

>NTDB_id=580331 I6L86_RS00390 WP_001019941.1 75222..75962(-) (comE/blpR) [Streptococcus mitis strain FDAARGOS 1456]
GTGAATATTTTTATACTAGAAGATAATTTTTTACAACAGACTAGAATTGAAAATGTTGTCAAAAAAATTTTGGTGGATAA
TAAGATTGAGTATAGGCATTTTGAGGTTTATGGAAAACCTCAACAGCTTTTAGAGGACATTTCAGAGAGAGGAAATCATC
AATTATTTTTACTTGATATTGAAATAAAAGATGATGACAAAAGAGGATTAGACGTTGCTAGAGAAATTAGAAAACTTGAT
TCTCAAGCAGTGATTGCTTTTGTAACATCTCATTCTGAGTTTATGCCTGTATCTTTTGAATATTTAGTATCAGCTATTGA
TTTCATTGATAAAGAATTACCTGAACCATTATTTATCAAACGAATTGAAAATGTTATTTTAAGTGTTAGCGATAATCAAG
GAATAACAGTATCTGAGGACTCTTTTATATTTACAGGATCCAAAGCTCAAATTCAAGTCCCTTTTAAAGATTTATTGTAT
ATTGAAACATCAACAATTGCTCATAAGTTGACTCTCTATTCAAAACGAGACATAGTTGAATTTTATGGACAATTGTCAGA
TATTCTTAAACAGGAACCACGTTTATTTCAATGTCATAGATCATTTATCGTAAATCCTTATAATATATCTTTAATTGATA
AAGAAAATCGGTTAGTTCATTTTCAGAACGGGTCCTCTTGTATTGTCTCTAGATTAAAAATTCGTCCACTTATGAAAGTT
ATCGAAAGACTTCATGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	52.066	98.374	0.512
comE/comE1	Streptococcus equinus JB1	44.538	96.748	0.431
comE	Streptococcus mitis SK321	36.8	100	0.374
comE	Streptococcus mitis NCTC 12261	36.8	100	0.374
comE	Streptococcus pneumoniae Rx1	36.4	100	0.37
comE	Streptococcus pneumoniae R6	36.4	100	0.37
comE	Streptococcus pneumoniae D39	36.4	100	0.37
comE	Streptococcus pneumoniae TIGR4	36.4	100	0.37
comE	Streptococcus infantis strain Atu-4	36	100	0.366
comE/comE2	Streptococcus equinus JB1	36.885	99.187	0.366
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	36.437	100	0.366
comE/comE2	Streptococcus gordonii strain NCTC7865	36.437	100	0.366