Detailed information NTG0550532

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: J5M87_RS02650
• Genome accession: NZ_CP072115
• Coordinates: 522453..523187 (+)
• Length: 244 a.a.
• NCBI ID: WP_154608208.1
• Uniprot ID: A0A6I4RBP8
• Organism: Streptococcus zhangguiae strain zg-86
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 517453..528187

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J5M87_RS02630 (J5M87_02630)	-	518479..519147 (+)	669	WP_154608204.1	ABC transporter ATP-binding protein	-
J5M87_RS02635 (J5M87_02635)	murF	519271..520635 (+)	1365	WP_154608205.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
J5M87_RS02640 (J5M87_02640)	-	520722..521414 (+)	693	WP_160463209.1	YwaF family protein	-
J5M87_RS02645 (J5M87_02645)	-	521900..522289 (-)	390	WP_154608207.1	hypothetical protein	-
J5M87_RS02650 (J5M87_02650)	comE/blpR	522453..523187 (+)	735	WP_154608208.1	response regulator transcription factor	Regulator
J5M87_RS02655 (J5M87_02655)	-	523184..524533 (+)	1350	WP_154608209.1	sensor histidine kinase	-
J5M87_RS02660 (J5M87_02660)	-	524845..525582 (+)	738	WP_154608210.1	amino acid transporter	-
J5M87_RS02665 (J5M87_02665)	-	525634..526506 (+)	873	WP_154608211.1	ABC transporter ATP-binding protein	-
J5M87_RS02670 (J5M87_02670)	-	526511..527284 (+)	774	WP_154608212.1	hypothetical protein	-

Sequence

Protein

• Length: 244 a.a.
• Molecular weight: 28265.10 Da
• Isoelectric Point: 5.2235

>NTDB_id=550532 J5M87_RS02650 WP_154608208.1 522453..523187(+) (comE/blpR) [Streptococcus zhangguiae strain zg-86]
MLNIFVLEDDFVQQARLEQAIQACVQKGDIGYQKLAIFGKPQQLLEAIQETGNHQFFFLDIEIRGEEKRGMEIARDIRAK
DPKASIVFVTTHSEFMPITYKYRVSALDFIDKALSDEEFQEAIGDVLVHAYENLDSEVADDAFVFRTEHSNFQVPFSDIL
YFETSPTAHKVILTTKKGHMEFYGKLSEIAKSDNRLYQAHRSYVVNPRNIVSIDRTKFTVYFENEESCFVSRLKLKGLVE
RIER

Nucleotide

• Length: 735 bp

>NTDB_id=550532 J5M87_RS02650 WP_154608208.1 522453..523187(+) (comE/blpR) [Streptococcus zhangguiae strain zg-86]
ATGTTGAACATCTTTGTATTAGAAGATGATTTTGTACAACAGGCACGTTTGGAACAGGCTATTCAGGCTTGTGTTCAAAA
GGGCGATATAGGTTATCAAAAGCTAGCAATTTTTGGAAAGCCCCAGCAATTGCTAGAGGCAATTCAGGAGACGGGAAATC
ATCAATTTTTCTTTTTGGATATTGAAATCCGTGGTGAAGAAAAAAGAGGAATGGAAATTGCGCGGGACATTCGCGCCAAA
GATCCCAAGGCCAGTATTGTTTTTGTGACGACTCACTCAGAGTTTATGCCAATCACCTATAAGTATCGTGTATCAGCCTT
GGATTTTATCGACAAAGCCTTATCTGATGAGGAATTCCAAGAAGCGATTGGGGATGTCTTGGTTCATGCCTATGAAAATT
TGGACAGTGAGGTGGCAGATGATGCTTTTGTCTTTCGGACGGAGCATTCTAATTTTCAAGTGCCTTTTTCAGATATTCTC
TATTTTGAAACGTCACCGACGGCTCACAAGGTCATTTTAACGACGAAAAAGGGACACATGGAATTTTACGGAAAACTATC
AGAAATTGCTAAATCGGATAATAGACTTTACCAAGCTCATCGCTCGTATGTGGTCAATCCTAGAAATATTGTCAGTATAG
ATCGTACCAAGTTTACAGTCTATTTTGAAAATGAGGAAAGCTGTTTCGTATCGCGATTGAAGTTAAAAGGTTTAGTGGAG
AGAATTGAGAGATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-242)

3D structure

• AlphaFold DB: A0A6I4RBP8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	56.067	97.951	0.549
comE/comE1	Streptococcus equinus JB1	47.699	97.951	0.467
comE/comE2	Streptococcus equinus JB1	38.683	99.59	0.385
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	36.735	100	0.369
comE/comE2	Streptococcus gordonii strain NCTC7865	36.735	100	0.369
comE	Streptococcus pneumoniae Rx1	36.437	100	0.369
comE	Streptococcus pneumoniae D39	36.437	100	0.369
comE	Streptococcus pneumoniae R6	36.437	100	0.369
comE	Streptococcus pneumoniae TIGR4	36.437	100	0.369
comE	Streptococcus mitis SK321	36.437	100	0.369
comE	Streptococcus infantis strain Atu-4	36.437	100	0.369
comE	Streptococcus mitis NCTC 12261	36.437	100	0.369