Detailed information NTG0547071

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: J1N58_RS11120
• Genome accession: NZ_CP071697
• Coordinates: 2336172..2336909 (-)
• Length: 245 a.a.
• NCBI ID: WP_172079988.1
• Uniprot ID: -
• Organism: Streptococcus suis strain 1112S
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	2334841..2355616	2336172..2336909	within	0

Gene organization within MGE regions

Location: 2334841..2355616

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J1N58_RS11115 (J1N58_11115)	-	2334841..2336172 (-)	1332	WP_207560369.1	GHKL domain-containing protein	-
J1N58_RS11120 (J1N58_11120)	comE/blpR	2336172..2336909 (-)	738	WP_172079988.1	response regulator transcription factor	Regulator
J1N58_RS11125 (J1N58_11125)	-	2337126..2337200 (-)	75	WP_232503818.1	hypothetical protein	-
J1N58_RS11130 (J1N58_11130)	-	2337770..2337955 (-)	186	WP_024377598.1	hypothetical protein	-
J1N58_RS11135 (J1N58_11135)	dtd	2338017..2338460 (-)	444	WP_024377597.1	D-aminoacyl-tRNA deacylase	-
J1N58_RS11140 (J1N58_11140)	-	2338462..2340663 (-)	2202	WP_024415730.1	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	-
J1N58_RS11145 (J1N58_11145)	-	2340919..2343402 (+)	2484	WP_207560370.1	bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase	-
J1N58_RS11150 (J1N58_11150)	-	2343451..2344165 (-)	715	Protein_2174	DUF554 domain-containing protein	-
J1N58_RS11155 (J1N58_11155)	-	2344170..2344916 (-)	747	WP_024376191.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
J1N58_RS11160 (J1N58_11160)	prmA	2344918..2345871 (-)	954	WP_105131350.1	50S ribosomal protein L11 methyltransferase	-
J1N58_RS11165 (J1N58_11165)	-	2345903..2346802 (-)	900	WP_024415727.1	GIY-YIG nuclease family protein	-
J1N58_RS11170 (J1N58_11170)	-	2346815..2347285 (-)	471	WP_099806948.1	DUF3013 family protein	-
J1N58_RS11175 (J1N58_11175)	-	2347287..2347622 (-)	336	WP_029187566.1	MazG nucleotide pyrophosphohydrolase domain-containing protein	-
J1N58_RS11180 (J1N58_11180)	-	2347692..2348975 (+)	1284	WP_105101117.1	replication-associated recombination protein A	-
J1N58_RS11195 (J1N58_11195)	nrdG	2349416..2349988 (-)	573	WP_024376197.1	anaerobic ribonucleoside-triphosphate reductase activating protein	-
J1N58_RS11200 (J1N58_11200)	-	2350003..2350494 (-)	492	WP_099778106.1	GNAT family N-acetyltransferase	-
J1N58_RS12065 (J1N58_11205)	-	2350496..2350727 (-)	232	Protein_2183	metallophosphatase	-
J1N58_RS11995	-	2350854..2350988 (-)	135	WP_002939130.1	hypothetical protein	-
J1N58_RS11210 (J1N58_11210)	nrdD	2351081..2353252 (-)	2172	WP_104931111.1	anaerobic ribonucleoside-triphosphate reductase	-
J1N58_RS11215 (J1N58_11215)	-	2353396..2353569 (-)	174	WP_029174615.1	hypothetical protein	-
J1N58_RS11220 (J1N58_11220)	-	2353603..2354043 (-)	441	WP_207560371.1	DUF3021 domain-containing protein	-
J1N58_RS11225 (J1N58_11225)	-	2354040..2354483 (-)	444	WP_105148931.1	LytTR family DNA-binding domain-containing protein	-
J1N58_RS11230 (J1N58_11230)	-	2354652..2355053 (-)	402	WP_024376204.1	hypothetical protein	-
J1N58_RS11235 (J1N58_11235)	-	2355068..2355616 (-)	549	WP_024376205.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28470.26 Da
• Isoelectric Point: 5.0801

>NTDB_id=547071 J1N58_RS11120 WP_172079988.1 2336172..2336909(-) (comE/blpR) [Streptococcus suis strain 1112S]
MLNIFVLEDDFFQQSRLENAIRQCVEETSVRYKFLEVFGKPNQLLESIEEAGNHQFFFLDIEIKGEEKKGMEIAKEIRAR
DPYAVIVFVTTHSEFMPVTYRYRVSALDFIDKGLEDSDFQKAVSDVLVHAFENIDHTIAENSFIYKTETAHIQVPFSDIL
YFETSSTIHKVILKTKTGQTEFYGKVSDISKADERLYQAHRSCVVNPLNITRLDRTNHIAYFENGDSCFISRIKQGRLIE
LIEDK

Nucleotide

• Length: 738 bp

>NTDB_id=547071 J1N58_RS11120 WP_172079988.1 2336172..2336909(-) (comE/blpR) [Streptococcus suis strain 1112S]
ATGCTTAATATTTTTGTATTAGAAGATGATTTTTTTCAGCAGAGCAGGCTAGAAAATGCTATTAGGCAGTGTGTTGAAGA
AACGTCAGTAAGATATAAATTCCTAGAAGTTTTTGGTAAACCAAATCAGTTATTGGAATCAATTGAGGAAGCAGGCAATC
ACCAATTTTTCTTTTTAGATATTGAAATTAAAGGCGAAGAAAAGAAAGGAATGGAAATAGCTAAAGAAATCCGTGCTCGC
GATCCCTATGCTGTTATTGTCTTTGTAACAACTCACTCAGAATTTATGCCGGTAACGTATCGTTATCGGGTTTCTGCTTT
AGATTTTATAGATAAAGGCCTGGAGGATAGTGACTTTCAAAAGGCAGTATCAGATGTGTTAGTGCATGCTTTTGAAAATA
TTGATCATACTATAGCTGAAAATTCTTTTATATACAAAACTGAAACTGCTCATATTCAAGTCCCTTTTAGTGATATCCTT
TATTTTGAAACATCATCAACAATACATAAAGTCATTTTAAAAACCAAAACAGGTCAGACTGAGTTTTACGGGAAAGTATC
CGATATATCGAAAGCAGATGAACGACTTTACCAGGCACATCGTTCTTGTGTAGTGAATCCATTAAATATAACGAGATTGG
ACAGAACAAACCATATTGCCTATTTTGAGAATGGAGATTCTTGTTTCATATCTAGAATAAAACAAGGAAGATTGATAGAA
TTGATAGAGGATAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-241)

• Response regulator receiver domain (Response_reg) (4-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	55.285	100	0.555
comE/comE1	Streptococcus equinus JB1	48.117	97.551	0.469
comE/comE2	Streptococcus gordonii strain NCTC7865	38.71	100	0.392
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	38.71	100	0.392
comE/comE2	Streptococcus equinus JB1	41.379	94.694	0.392
comE	Streptococcus pneumoniae D39	37.45	100	0.384
comE	Streptococcus pneumoniae R6	37.45	100	0.384
comE	Streptococcus pneumoniae TIGR4	37.45	100	0.384
comE	Streptococcus infantis strain Atu-4	37.45	100	0.384
comE	Streptococcus mitis NCTC 12261	37.45	100	0.384
comE	Streptococcus mitis SK321	37.45	100	0.384
comE	Streptococcus pneumoniae Rx1	37.45	100	0.384