Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SSAL_RS07795 Genome accession   NC_017594
Coordinates   1687779..1688522 (+) Length   247 a.a.
NCBI ID   WP_002886749.1    Uniprot ID   -
Organism   Streptococcus salivarius 57.I     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1685838..1697922 1687779..1688522 within 0


Gene organization within MGE regions


Location: 1685838..1697922
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SSAL_RS07785 (Ssal_01714) tnpA 1685838..1686254 (-) 417 WP_002886752.1 IS200/IS605 family transposase -
  SSAL_RS10300 - 1686926..1687279 (-) 354 WP_013990160.1 hypothetical protein -
  SSAL_RS07795 (Ssal_01716) comE/blpR 1687779..1688522 (+) 744 WP_002886749.1 response regulator transcription factor Regulator
  SSAL_RS07800 (Ssal_01717) - 1688772..1689839 (+) 1068 WP_252866507.1 GHKL domain-containing protein -
  SSAL_RS07805 (Ssal_01719) - 1690497..1691213 (-) 717 WP_041817342.1 hypothetical protein -
  SSAL_RS07810 (Ssal_01720) - 1691228..1691887 (-) 660 WP_013990156.1 ABC transporter ATP-binding protein -
  SSAL_RS07815 (Ssal_01721) - 1692206..1692886 (-) 681 WP_014633514.1 hypothetical protein -
  SSAL_RS07820 (Ssal_01722) - 1692979..1693512 (-) 534 WP_014633515.1 hypothetical protein -
  SSAL_RS07825 (Ssal_01723) - 1693512..1694309 (-) 798 WP_014633516.1 thiol reductase thioredoxin -
  SSAL_RS07830 - 1694450..1694812 (-) 363 WP_045001901.1 hypothetical protein -
  SSAL_RS07835 (Ssal_01726) - 1694830..1695831 (-) 1002 WP_014633518.1 hypothetical protein -
  SSAL_RS07840 (Ssal_01727) - 1696640..1696948 (+) 309 WP_002886741.1 hypothetical protein -
  SSAL_RS07845 (Ssal_01728) - 1696987..1697922 (-) 936 WP_002886740.1 hypothetical protein -

Sequence

Protein


Download         Length: 247 a.a.        Molecular weight: 28781.30 Da        Isoelectric Point: 7.0440

>NTDB_id=49415 SSAL_RS07795 WP_002886749.1 1687779..1688522(+) (comE/blpR) [Streptococcus salivarius 57.I]
MLNIFILEDDFLQQSRIETVIKDVISKKSLKCKGPEIYGKPSQLLDAITERGSHQLFFLDIEIKGEEKKGLDIAKEIRKK
DPNATIVFVTTHSEFMPVTFKYRVAALDFIDKALNDEFFYERVRLAIEYTMDKLGATITQDSFTFETSMAHVQVPFNNIL
FFETSPTIHKVILHTKEERMEFYASISEVERADERLYRCHRSFIVNPENILKINKEEKMAMFDNNIGCPISRTKYRGLLE
KVKSMKS

Nucleotide


Download         Length: 744 bp        

>NTDB_id=49415 SSAL_RS07795 WP_002886749.1 1687779..1688522(+) (comE/blpR) [Streptococcus salivarius 57.I]
TTGTTAAATATTTTTATTTTAGAAGATGATTTCTTACAACAATCACGAATAGAAACAGTTATTAAGGATGTTATTTCAAA
AAAATCTCTAAAATGTAAAGGACCTGAGATTTATGGAAAACCTAGCCAATTACTTGACGCAATTACCGAAAGAGGCTCTC
ACCAACTTTTCTTTTTAGATATTGAAATCAAGGGTGAAGAAAAGAAGGGGCTAGACATTGCTAAAGAAATTCGAAAAAAA
GATCCTAATGCAACAATTGTTTTTGTAACAACACACTCAGAATTCATGCCAGTCACTTTTAAATATAGAGTTGCTGCCCT
AGATTTTATTGATAAAGCTTTGAATGATGAGTTTTTTTATGAACGTGTCCGTTTAGCAATTGAATATACTATGGATAAAC
TGGGGGCTACCATTACCCAAGATTCATTTACTTTTGAAACATCAATGGCCCACGTTCAAGTGCCTTTTAACAATATTTTA
TTTTTTGAAACGTCTCCAACAATACATAAGGTTATTTTGCATACTAAAGAAGAAAGAATGGAGTTTTACGCAAGTATTTC
AGAAGTTGAGCGTGCTGACGAACGCTTATATCGATGCCATCGTTCGTTTATCGTTAATCCTGAAAATATCCTTAAAATCA
ACAAAGAAGAAAAAATGGCAATGTTTGATAACAATATTGGATGTCCCATCTCCCGTACGAAATATAGGGGCCTTTTGGAG
AAGGTTAAATCGATGAAAAGCTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-122)

LytTr DNA-binding domain (LytTR)

(152-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.772

97.571

0.534
  comE/comE1 Streptococcus equinus JB1

44.856

98.381

0.441
  comE/comE2 Streptococcus gordonii strain NCTC7865

38.057

100

0.381
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

38.057

100

0.381
  comE/comE2 Streptococcus equinus JB1

37.805

99.595

0.377
  comE Streptococcus pneumoniae R6

37.759

97.571

0.368
  comE Streptococcus pneumoniae TIGR4

37.759

97.571

0.368
  comE Streptococcus mitis SK321

37.759

97.571

0.368
  comE Streptococcus mitis NCTC 12261

37.759

97.571

0.368
  comE Streptococcus pneumoniae Rx1

37.759

97.571

0.368
  comE Streptococcus pneumoniae D39

37.759

97.571

0.368
  comE Streptococcus infantis strain Atu-4

36.929

97.571

0.36

Multiple sequence alignment