Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   H7795_RS00670 Genome accession   NZ_CP060641
Coordinates   103981..104919 (+) Length   312 a.a.
NCBI ID   WP_023613135.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain TSPY210     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 98981..109919
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7795_RS00660 (H7795_00655) rpoC 99730..103371 (+) 3642 WP_023613125.1 DNA-directed RNA polymerase subunit beta' -
  H7795_RS00665 (H7795_00660) - 103523..103888 (+) 366 WP_002986560.1 DUF1033 family protein -
  H7795_RS00670 (H7795_00665) comYA 103981..104919 (+) 939 WP_023613135.1 competence type IV pilus ATPase ComGA Machinery gene
  H7795_RS00675 (H7795_00670) comYB 104855..105889 (+) 1035 WP_258855794.1 competence type IV pilus assembly protein ComGB Machinery gene
  H7795_RS00680 (H7795_00675) comYC 105891..106217 (+) 327 WP_032465607.1 competence type IV pilus major pilin ComGC Machinery gene
  H7795_RS00685 (H7795_00680) comGD 106192..106620 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  H7795_RS00690 (H7795_00685) comGE 106577..106861 (+) 285 WP_002987779.1 competence type IV pilus minor pilin ComGE -
  H7795_RS00695 (H7795_00690) comYF 106854..107288 (+) 435 WP_023612536.1 competence type IV pilus minor pilin ComGF Machinery gene
  H7795_RS00700 (H7795_00695) comGG 107272..107598 (+) 327 WP_002992739.1 competence type IV pilus minor pilin ComGG -
  H7795_RS00705 (H7795_00700) comYH 107696..108649 (+) 954 WP_002987790.1 class I SAM-dependent methyltransferase Machinery gene
  H7795_RS00710 (H7795_00705) - 108708..109904 (+) 1197 WP_023612537.1 acetate kinase -

Sequence

Protein


Download         Length: 312 a.a.        Molecular weight: 35018.25 Da        Isoelectric Point: 8.5799

>NTDB_id=477071 H7795_RS00670 WP_023613135.1 103981..104919(+) (comYA) [Streptococcus pyogenes strain TSPY210]
MVQALAKAILAKAEQVQAQDIYILPRADQYDLFLRIGDERRLVDVYQSDRMAPLISHFKFVAGMIVGEKRRCQVGSCDYK
LSKDKQLSLRLSSVGDYRGQESLVIRLLHHQNKSVHYWFDGLTKVANQVGGRGLYLFAGPVGSGKTTLMYQLISSYHQEA
QVISIEDPVEIKNHQILQLQVNDDIGMTYDNLIKLSLRHRPDILVIGEIRDSQTARAVIRASLTGAMVFSTVHAKSISGV
YARLLELGVTKAELSNCLALIAYQRLLNGGALIDSTQNEFEYYSSSNWNQQIDQLLDAGHINPKQAKLEKII

Nucleotide


Download         Length: 939 bp        

>NTDB_id=477071 H7795_RS00670 WP_023613135.1 103981..104919(+) (comYA) [Streptococcus pyogenes strain TSPY210]
ATGGTACAAGCATTAGCAAAAGCTATTCTAGCAAAAGCTGAACAGGTTCAGGCACAAGATATTTATATTTTGCCAAGAGC
AGATCAATATGATCTTTTTTTACGAATAGGAGATGAAAGGAGATTAGTTGATGTTTATCAGAGCGATCGGATGGCTCCTC
TTATTAGTCACTTTAAATTCGTTGCAGGAATGATAGTTGGTGAAAAGAGACGTTGTCAGGTGGGTTCATGTGATTATAAG
CTTAGTAAAGATAAGCAGTTATCTTTGCGCTTATCTAGCGTGGGTGATTATCGCGGGCAAGAAAGCTTAGTGATTCGTCT
GCTTCATCATCAAAATAAAAGTGTACATTATTGGTTTGATGGATTGACAAAAGTAGCCAATCAAGTTGGCGGTAGAGGGT
TGTATTTATTTGCAGGACCAGTTGGGTCTGGGAAGACAACCTTGATGTACCAGCTGATTTCGAGTTATCATCAAGAAGCA
CAGGTTATTAGTATAGAAGATCCTGTAGAAATTAAAAATCACCAGATTTTACAATTACAAGTGAATGATGATATTGGTAT
GACTTATGACAATTTGATCAAACTGTCTTTACGCCATCGACCAGATATTTTAGTTATTGGTGAGATTCGAGATAGTCAAA
CAGCAAGAGCCGTTATTAGGGCTAGCCTAACAGGTGCCATGGTTTTTTCAACGGTTCACGCTAAAAGTATCTCGGGTGTT
TATGCAAGATTGTTAGAACTTGGTGTAACGAAAGCAGAACTGTCTAATTGCTTAGCATTAATTGCTTACCAAAGGTTACT
TAATGGAGGAGCATTGATTGACTCTACTCAAAACGAATTTGAATATTATTCCTCATCGAACTGGAATCAACAAATTGATC
AGCTTCTTGATGCAGGACATATCAATCCCAAGCAAGCTAAGCTTGAAAAAATTATCTAG

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus mutans UA140

62.058

99.679

0.619
  comYA Streptococcus mutans UA159

62.058

99.679

0.619
  comYA Streptococcus gordonii str. Challis substr. CH1

61.093

99.679

0.609
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

60.323

99.359

0.599
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

60.129

99.679

0.599
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

59.486

99.679

0.593
  comGA/cglA/cilD Streptococcus pneumoniae D39

59.486

99.679

0.593
  comGA/cglA/cilD Streptococcus pneumoniae R6

59.486

99.679

0.593
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

59.486

99.679

0.593
  comGA Lactococcus lactis subsp. cremoris KW2

50.161

99.679

0.5
  comGA Latilactobacillus sakei subsp. sakei 23K

39.655

92.949

0.369