Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Regulator
Locus tag   HW271_RS08705 Genome accession   NZ_CP058258
Coordinates   1760499..1761251 (-) Length   250 a.a.
NCBI ID   WP_178895632.1    Uniprot ID   A0A7H8ZA53
Organism   Streptococcus sp. oral taxon 061 strain F0704     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1755499..1766251
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HW271_RS08685 (HW271_08685) - 1756930..1759584 (-) 2655 WP_178895630.1 YhgE/Pip domain-containing protein -
  HW271_RS08690 (HW271_08690) - 1759713..1760255 (+) 543 WP_178895631.1 TetR/AcrR family transcriptional regulator -
  HW271_RS08705 (HW271_08705) comE 1760499..1761251 (-) 753 WP_178895632.1 competence system response regulator transcription factor ComE Regulator
  HW271_RS08710 (HW271_08710) comD 1761248..1762567 (-) 1320 WP_178895633.1 competence system sensor histidine kinase ComD Regulator
  HW271_RS08720 (HW271_08720) rlmH 1762851..1763330 (-) 480 WP_178895634.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  HW271_RS08725 (HW271_08725) htrA 1763516..1764697 (+) 1182 WP_178895635.1 S1C family serine protease Regulator
  HW271_RS08730 (HW271_08730) spo0J 1764757..1765518 (+) 762 WP_178895636.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29869.29 Da        Isoelectric Point: 8.0329

>NTDB_id=463262 HW271_RS08705 WP_178895632.1 1760499..1761251(-) (comE) [Streptococcus sp. oral taxon 061 strain F0704]
MKVLILEDVIQHQVRLERTLDEISKELNIPISYKTTGKEREFKEYIENDEVNQLYFLDIDIHGVEKKGFEVAQFIRRHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSILYTKSMLLENKDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMADIQEKDKDTQRFYSAHKSFLVNVGNIREIDRKNLEVVFYEEHRCPITRLKVRKL
RDILEKKSKK

Nucleotide


Download         Length: 753 bp        

>NTDB_id=463262 HW271_RS08705 WP_178895632.1 1760499..1761251(-) (comE) [Streptococcus sp. oral taxon 061 strain F0704]
ATGAAAGTATTAATTTTAGAAGATGTTATTCAACATCAAGTCAGATTAGAAAGAACCTTGGATGAAATTTCAAAGGAATT
GAATATTCCTATTTCTTATAAAACAACAGGTAAAGAACGAGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTTCTAGATATTGATATTCATGGAGTTGAGAAAAAAGGATTTGAGGTAGCACAGTTTATTCGTCGCCACAATCCC
TATGCAATTATCGTATTTATCACTAGTAGATCAGAATTTGCTACCTTAACTTACAAATATCAAGTATCAGCCTTGGATTT
TGTTGATAAAGATATCAATGATGAATTATTTAAAAAACGTATCGAACAGAGTATCTTATATACCAAAAGTATGCTGCTTG
AAAATAAAGATGTTGTGGATTATTTTGACTATAACTACAAAGGAAATGATTTAAAAATTCCCTACCATGATATTTTATAT
ATTGAAACAACAGGAGTATCTCATAAGTTAAGGATTATTGGTAAGAATTTTGCCAAAGAATTTTATGGGACTATGGCGGA
TATTCAAGAAAAAGATAAAGATACTCAAAGATTTTATTCTGCTCATAAATCATTTCTTGTTAATGTAGGAAATATTAGGG
AAATTGATCGAAAAAATTTAGAAGTGGTTTTTTATGAGGAACATCGCTGCCCGATTACCCGTCTCAAGGTTCGGAAATTA
AGAGATATTCTGGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-244)

Response regulator receiver domain (Response_reg)

(32-121)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7H8ZA53

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Streptococcus infantis strain Atu-4

99.6

100

0.996
  comE Streptococcus mitis NCTC 12261

92.4

100

0.924
  comE Streptococcus mitis SK321

91.6

100

0.916
  comE Streptococcus pneumoniae Rx1

90.8

100

0.908
  comE Streptococcus pneumoniae D39

90.8

100

0.908
  comE Streptococcus pneumoniae R6

90.8

100

0.908
  comE Streptococcus pneumoniae TIGR4

90.8

100

0.908
  comE/comE2 Streptococcus gordonii strain NCTC7865

64

100

0.64
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

64

100

0.64
  comE/blpR Streptococcus mutans UA159

41.7

98.8

0.412