Detailed information NTG0463264

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: HW271_RS08725
• Genome accession: NZ_CP058258
• Coordinates: 1763516..1764697 (+)
• Length: 393 a.a.
• NCBI ID: WP_178895635.1
• Uniprot ID: A0A7H8ZBD7
• Organism: Streptococcus sp. oral taxon 061 strain F0704
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1758516..1769697

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HW271_RS08690 (HW271_08690)	-	1759713..1760255 (+)	543	WP_178895631.1	TetR/AcrR family transcriptional regulator	-
HW271_RS08705 (HW271_08705)	comE	1760499..1761251 (-)	753	WP_178895632.1	competence system response regulator transcription factor ComE	Regulator
HW271_RS08710 (HW271_08710)	comD	1761248..1762567 (-)	1320	WP_178895633.1	competence system sensor histidine kinase ComD	Regulator
HW271_RS08720 (HW271_08720)	rlmH	1762851..1763330 (-)	480	WP_178895634.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
HW271_RS08725 (HW271_08725)	htrA	1763516..1764697 (+)	1182	WP_178895635.1	S1C family serine protease	Regulator
HW271_RS08730 (HW271_08730)	spo0J	1764757..1765518 (+)	762	WP_178895636.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41515.41 Da
• Isoelectric Point: 5.2327

>NTDB_id=463264 HW271_RS08725 WP_178895635.1 1763516..1764697(+) (htrA) [Streptococcus sp. oral taxon 061 strain F0704]
MKNFNKFSKTIGQLLLVILISFFSGLLGSLAVLQFNQKQGRGEQNSAAITQTASKNENSTTQAVDKVKDAVVSVITYSSN
SQNSLLGSDETDTDTNSEQVYSEGSGVIYKKEGDTAYLVTNTHVINGAKKVDIRLADGTKVPGEIVGSDTYSDIAVVKIA
ADKVTTVAEFGDSSQLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTNAIQTDTAINPGNSGGPLI
NIQGQVIGITSSKIASNGGTSVEGLGFAIPANDVINIIKQLEKDGKVTRPALGIHMVNLSNLSTTDLQKLKLPGNVTSGV
AVRSVQKNMPANGHLQQYDVITKVDDTKISSTTELQNALYSHSIGDEMTVTYYRNGKEEKTTIKLDKSTSDLN

Nucleotide

• Length: 1182 bp

>NTDB_id=463264 HW271_RS08725 WP_178895635.1 1763516..1764697(+) (htrA) [Streptococcus sp. oral taxon 061 strain F0704]
ATGAAAAACTTTAACAAGTTTTCAAAAACAATTGGACAACTTTTACTAGTTATTCTTATTAGCTTTTTTAGTGGTCTATT
AGGAAGTTTGGCTGTTCTTCAATTCAACCAAAAGCAAGGAAGGGGAGAACAAAATAGTGCAGCGATCACTCAGACTGCTT
CGAAAAATGAAAATTCTACCACACAGGCTGTAGATAAAGTTAAAGATGCTGTTGTATCTGTCATTACTTACTCATCAAAC
TCTCAAAATAGTTTACTCGGATCTGATGAAACTGATACAGATACCAATTCTGAACAAGTATACAGCGAAGGTTCTGGTGT
CATTTATAAAAAGGAAGGGGATACTGCTTACCTTGTAACCAATACTCACGTTATTAATGGTGCTAAAAAAGTTGATATTC
GTTTAGCAGATGGCACAAAAGTCCCTGGTGAAATTGTGGGTTCTGATACTTATTCAGATATTGCCGTTGTAAAAATTGCT
GCAGATAAAGTCACAACAGTAGCCGAATTTGGTGATTCTAGTCAATTAACAGTTGGAGAAACAGCTATTGCAATCGGAAG
TCCTCTAGGTTCTGAATATGCCAATACTGTGACACAGGGGATTGTATCAAGTTTAAATAGAAATGTATCTCTAAAATCTG
AAGACGGACAAGCTATCTCAACCAATGCTATCCAAACAGATACAGCTATTAACCCTGGGAACTCAGGTGGTCCTTTGATT
AATATCCAAGGCCAAGTTATCGGTATTACATCAAGTAAGATTGCCTCTAATGGTGGAACATCTGTCGAAGGTCTTGGTTT
TGCCATTCCTGCAAACGATGTAATCAATATTATTAAGCAGTTGGAAAAAGATGGAAAAGTAACTCGACCTGCTCTTGGAA
TCCACATGGTTAACTTATCAAATCTTAGTACAACTGATCTTCAAAAACTAAAACTTCCTGGAAATGTTACTTCTGGTGTA
GCTGTTCGTTCTGTTCAAAAAAATATGCCTGCAAATGGACATTTACAACAATATGATGTCATCACAAAAGTAGATGATAC
CAAGATTTCATCTACAACTGAATTGCAAAATGCTCTATATAGTCACTCTATTGGAGATGAAATGACTGTAACTTATTACC
GTAATGGTAAAGAAGAAAAAACTACAATCAAACTAGATAAGAGTACAAGTGATTTAAATTAA

Domains

Predicted by InterproScan.

• Peptidase family M50 (Peptidase_M50) (265-388)

• Trypsin-like peptidase domain (Trypsin_2) (104-249)

• PDZ domain (PDZ_2) (290-385)

3D structure

• AlphaFold DB: A0A7H8ZBD7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mitis NCTC 12261	77.608	100	0.776
htrA	Streptococcus pneumoniae Rx1	77.354	100	0.774
htrA	Streptococcus pneumoniae D39	77.354	100	0.774
htrA	Streptococcus pneumoniae R6	77.354	100	0.774
htrA	Streptococcus pneumoniae TIGR4	77.354	100	0.774
htrA	Streptococcus gordonii str. Challis substr. CH1	67.172	100	0.677
htrA	Streptococcus mutans UA159	52.806	99.746	0.527