Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD   Type   Regulator
Locus tag   HW271_RS08710 Genome accession   NZ_CP058258
Coordinates   1761248..1762567 (-) Length   439 a.a.
NCBI ID   WP_178895633.1    Uniprot ID   A0A7H8ZA57
Organism   Streptococcus sp. oral taxon 061 strain F0704     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1756248..1767567
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HW271_RS08685 (HW271_08685) - 1756930..1759584 (-) 2655 WP_178895630.1 YhgE/Pip domain-containing protein -
  HW271_RS08690 (HW271_08690) - 1759713..1760255 (+) 543 WP_178895631.1 TetR/AcrR family transcriptional regulator -
  HW271_RS08705 (HW271_08705) comE 1760499..1761251 (-) 753 WP_178895632.1 competence system response regulator transcription factor ComE Regulator
  HW271_RS08710 (HW271_08710) comD 1761248..1762567 (-) 1320 WP_178895633.1 competence system sensor histidine kinase ComD Regulator
  HW271_RS08720 (HW271_08720) rlmH 1762851..1763330 (-) 480 WP_178895634.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  HW271_RS08725 (HW271_08725) htrA 1763516..1764697 (+) 1182 WP_178895635.1 S1C family serine protease Regulator
  HW271_RS08730 (HW271_08730) spo0J 1764757..1765518 (+) 762 WP_178895636.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 439 a.a.        Molecular weight: 51315.51 Da        Isoelectric Point: 6.5912

>NTDB_id=463263 HW271_RS08710 WP_178895633.1 1761248..1762567(-) (comD) [Streptococcus sp. oral taxon 061 strain F0704]
MDLLKILIVILHILILTNSYELICKAIKKERYLFISWVFILQSIVEILFYLTSLHGLGMEKISFTCIIFAYLIGFKKYNK
FKAIFISLLLSLLYQSTHTFIAVIISSITGDSFLIKYEDLFFVVVLMLTYFITKKIITYFHLELTYFDKNYLYPFFKKVI
LIFFTLQVLLFISDMVGIHAHFNNFSSILATIVFICLLLIFFAMNSHKVRVEKEIALKQKKFEQEHLQTYTDEIVGLYNE
IRGFRHDYAGMLVSMQMAIDSGDLQEIYRVYNEVLVKANQKLRSDKYTYFDLNNIEDSALRSLIAQSIVYARNNDVEFTL
EVKDIITRLSIDLLDLVRIMSVLLNNAVEGAAESYLKQMEVAVIKMDLETVIVIQNSCRITMTPSEDLFELGFSTKGRNR
GIGLNNVKEILDKYENIILETEMEDSTFRQIIRFKREFE

Nucleotide


Download         Length: 1320 bp        

>NTDB_id=463263 HW271_RS08710 WP_178895633.1 1761248..1762567(-) (comD) [Streptococcus sp. oral taxon 061 strain F0704]
ATGGATTTATTGAAAATACTCATAGTTATTCTTCATATTCTTATTCTAACAAATAGCTATGAACTCATTTGTAAGGCAAT
AAAAAAAGAAAGATATCTGTTTATTTCTTGGGTATTTATATTACAGTCTATTGTTGAAATTTTATTCTATTTAACTTCTT
TACATGGATTAGGAATGGAAAAAATTTCATTTACCTGTATTATCTTTGCTTATTTAATAGGATTTAAAAAATATAATAAG
TTCAAAGCTATTTTTATTAGTTTATTATTGTCTTTATTATATCAAAGTACTCATACATTTATAGCAGTAATCATATCCTC
TATAACAGGTGATTCTTTCTTAATAAAATATGAAGATTTATTTTTTGTAGTGGTTTTGATGCTGACGTATTTTATCACTA
AAAAAATTATTACTTATTTTCATCTTGAACTTACTTATTTTGATAAAAATTACCTTTATCCATTTTTCAAAAAGGTCATT
TTAATTTTCTTTACTTTACAAGTTCTATTATTCATTTCAGATATGGTGGGTATTCATGCTCATTTTAATAATTTCAGTAG
TATTTTAGCAACAATTGTCTTTATCTGTTTACTACTAATATTCTTCGCTATGAATTCTCATAAGGTGCGAGTTGAAAAAG
AAATTGCCCTAAAACAGAAAAAATTTGAACAAGAACATTTACAGACATATACAGATGAAATTGTTGGTTTGTACAATGAA
ATCCGTGGTTTTCGTCATGATTATGCAGGTATGCTTGTTAGTATGCAAATGGCGATTGATAGTGGAGATTTACAGGAAAT
TTACAGGGTTTACAATGAAGTTCTAGTCAAAGCTAATCAAAAATTACGTTCAGATAAGTATACATACTTTGATTTAAACA
ATATAGAAGATTCAGCTTTACGAAGTTTGATTGCTCAATCTATTGTATATGCCAGAAATAATGACGTAGAGTTTACATTA
GAAGTAAAGGATATTATCACAAGATTGTCAATCGATTTACTCGATCTTGTTCGTATTATGAGTGTTTTGTTAAATAATGC
TGTTGAGGGTGCTGCAGAAAGTTATTTAAAACAAATGGAAGTTGCAGTGATTAAGATGGATTTAGAAACAGTTATCGTGA
TTCAAAATTCGTGTAGAATTACTATGACACCTTCAGAAGACTTGTTTGAACTAGGTTTTTCTACTAAAGGTAGAAATAGA
GGAATTGGCCTTAATAATGTCAAAGAGATTTTGGATAAGTATGAAAATATCATTTTAGAGACAGAGATGGAAGATAGTAC
GTTTAGACAGATTATTAGATTTAAGAGAGAGTTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(333-432)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7H8ZA57

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD Streptococcus mitis NCTC 12261

72.562

100

0.729
  comD/comD2 Streptococcus pneumoniae TIGR4

71.202

100

0.715
  comD/comD1 Streptococcus pneumoniae Rx1

69.841

100

0.702
  comD/comD1 Streptococcus pneumoniae D39

69.841

100

0.702
  comD/comD1 Streptococcus pneumoniae R6

69.841

100

0.702
  comD Streptococcus mitis SK321

69.388

100

0.697
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

50.404

84.51

0.426
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.337

85.877

0.424